AutismKB 2.0

Annotation Detail for RHOBTB2


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Basic Information Top
Gene Symbol:RHOBTB2 ( DBC2,KIAA0717 )
Gene Full Name: Rho-related BTB domain containing 2
Band: 8p21.3
Quick LinksEntrez ID:23221; OMIM: 607352; Uniprot ID:RHBT2_HUMAN; ENSEMBL ID: ENSG00000008853; HGNC ID: 18756
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
Pathway IDPathway Name
Signaling by Rho GTPases
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012277 1,2-diamino-4-nitrobenzene 1,2-diamino-4-nitrobenzene results in increased expression of RHOBTB2 mRNAincreases expression 17070881
C035314 1-nitropropane 1-nitropropane results in increased expression of RHOBTB2 mRNAincreases expression 17070881
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of RHOBTB2 mRNAincreases expression 17070881
C025235 2,6-diaminotoluene 2,6-diaminotoluene affects the expression of RHOBTB2 mRNAaffects expression 17070881
C014706 2-nitro-4-phenylenediamine 2-nitro-4-phenylenediamine results in increased expression of RHOBTB2 mRNAincreases expression 17070881
C016617 2-nitropropane 2-nitropropane results in increased expression of RHOBTB2 mRNAincreases expression 17070881
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RHOBTB2 mRNAdecreases expression 18648102
C028676 4-acetylaminofluorene 4-acetylaminofluorene results in increased expression of RHOBTB2 mRNAincreases expression 17070881
C006780 bisphenol A bisphenol A results in increased expression of RHOBTB2 mRNAincreases expression 20678512
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RHOBTB2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RHOBTB2 mRNAaffects cotreatment|increases expression 17942748
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of RHOBTB2 mRNAincreases expression 17070881
D008628 Mercury Mercury results in increased expression of RHOBTB2 mRNAincreases expression 16823088
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RHOBTB2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 7.1510737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.153712494
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.146705139
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Mercury 2.7817497416
MESH:D001327 Autoimmune Diseases Mercury 4.9816634805
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001862 Bone Resorption bisphenol A 3.9411985600
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 1.9811921183
MESH:D001943 Breast Neoplasms bisphenol A 1.9817123778
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 3.3517761372 6705139 3581430 10737359 3084413
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.353581430 7296757
MESH:D002278 Carcinoma in Situ bisphenol A 5.1117123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4810334427
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.817505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.069022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0616105132 17110522 17681005 17333356 16919318 11677210 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 12621046 8697196 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.538970840 2524372 18759878 14531868 8156756 11906362 12868966 11298694
MESH:D017449 Dermatitis, Allergic Contact Mercury 7.5316823706
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2-nitropropane 6.5320517888 16445897 15804453
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.5318289764 1440618 18692083 9328219 8291058 6679447 18648102 9022650 7440962 9653073 6482804 11289319 16192314
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.8915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.456705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.496705139
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 16959395 8697196 18606429 16354765
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 3.3416393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.159022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Mercury 3.6017934191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.036582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 4.8214678523 11376686 16273603 10737359 18001218 10672840
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8216984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 10.19534488 6150874 1399818
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.19598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1912151625
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 2.6011376686
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6011884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.6311921183
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009336 Necrosis 2-nitropropane 5.6812195237
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009421 Nervous System Malformations bisphenol A 9.9011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.9014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.506482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010049 Ovarian Diseases bisphenol A 5.1111985600
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.9010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.9011399792 11222880 11118676 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3916740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 4.9010548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D019966 Substance-Related Disorders bisphenol A 4.1016684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.957505956 6587162 1399818 6582329 3712494
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 5.471399818 15289314 15867355
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.478074119
MESH:D014591 Uterine Diseases bisphenol A 5.1414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
REACT:11044 Signaling by Rho GTPases
KEGG:04120 Ubiquitin mediated proteolysis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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