AutismKB 2.0

Annotation Detail for NUP210


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NUP210 ( FLJ22389,GP210,KIAA0906,POM210 )
Gene Full Name: nucleoporin 210kDa
Band: 3p25.1
Quick LinksEntrez ID:23225; OMIM: 607703; Uniprot ID:PO210_HUMAN; ENSEMBL ID: ENSG00000132182; HGNC ID: 30052
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of carbohydrates
Transmembrane transport of small molecules
HIV Infection
Pathway IDPathway Name
200070Signaling events mediated by HDAC Class I
200019Signaling events mediated by HDAC Class II
200097Sumoylation by RanBP2 regulates transcriptional repression
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NUP210 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NUP210 mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of NUP210 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NUP210 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of NUP210 mRNAaffects expression 18414638
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NUP210 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NUP210 mRNAdecreases expression 19150397
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NUP210 mRNAaffects cotreatment|affects expression 17602206
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NUP210 mRNAaffects cotreatment|increases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NUP210 mRNAaffects cotreatment|increases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of NUP210 mRNAaffects cotreatment|increases expression 16931933
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NUP210 mRNAaffects cotreatment|affects expression 17602206
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NUP210 mRNAaffects cotreatment|increases expression 16931933
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NUP210 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of NUP210 mRNAdecreases expression 17426115
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NUP210 mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NUP210 mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NUP210 mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of NUP210 mRNAaffects cotreatment|increases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.037525203
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.909612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.313712494
MESH:D000236 Adenoma Benzo(a)pyrene 11.316695378
MESH:D000236 Adenoma Diethylnitrosamine 11.3110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.3716434500 19061943 17162532 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3716434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3117306315
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8818414634 12569548 16835338 16251483
MESH:D050197 Atherosclerosis Arsenic 3.2819371607 12928151
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0817474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0817474063
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6217687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.667296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.6617306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6616878318 20432363 19539802 17173139 10737359 16681979 20727157 20007298 16569478 11831363 20514400 16540662 19418558 18785209 18971187 3581430 18210153 20935162 10672840 16807293 19701751 17162532 18788625 20101231 20214788 18494052 16935385 18978308 17055752 20084675 19383236 19335982 19107877 17138121 3084413 16779866 18665156 16698587 20512989 20524982 18393292 17761372 19208518 19171122 19052882 16830150 16502159 16288022 19919837 18506893 16328049 21159647 19519916 18056438 18691550 17428255 17978847 19822196 19394651
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.7618922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7620419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1318640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.4815738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.3616973168 18022660
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.6614694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.336135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.337505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.3320889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.3317174075 21159647 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7319052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.989022650 19486331
MESH:D002779 Cholestasis pirinixic acid 7.9819176532
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.2115095906
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8711298694 2524372 11906362 8156756 8970840 18759878 14531868 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.553621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2020387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.1521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.1516192314 11289319 18289764 9022650 7440962 18648102 8291058 18692083 1440618 9328219 6482804 6679447 9653073
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.1521346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.1519107877
MESH:D004362 Drug Toxicity Lamivudine 8.9215040536
MESH:D004362 Drug Toxicity Zidovudine 8.9215040536
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.263581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2616530937
MESH:D005234 Fatty Liver Diethylnitrosamine 13.5220387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 13.5219236843 20131406
MESH:D005234 Fatty Liver Zidovudine 13.5218299183
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D005534 Foot Diseases Arsenic 5.666392382
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6820471113
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006402 Hematologic Diseases Zidovudine 4.7712579204
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006509 Hepatitis B Lamivudine 5.1517703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.1512044531 15631357 15274664 16476009 15309715
MESH:D006529 Hepatomegaly pirinixic acid 3.0719176532 16221962 19772884 18467677
MESH:D015658 HIV Infections Indinavir 15.7515388451 11141242 11363243
MESH:D015658 HIV Infections Lamivudine 15.7520032539 11141242 9296927 17530837
MESH:D015658 HIV Infections Saquinavir 15.7515388451 11141242
MESH:D015658 HIV Infections Zidovudine 15.7511363243 20032539 11141242 11698656 17358032
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5117050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Arsenic 2.8911953799 9931084 16076760
MESH:D006987 Hypesthesia Arsenic 5.6616093927
MESH:D007249 Inflammation Diethylnitrosamine 2.4018785209
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007642 Keratosis Arsenic 5.0716930632 12749816
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.7816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.786582329
MESH:D007680 Kidney Neoplasms Zidovudine 12.7812579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.4720370541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5917339181
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8518665156 18522880 20032147 19638242 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Arsenic 4.2811134558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2817034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.257678174
MESH:D008113 Liver Neoplasms Arsenic 18.2516368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.2521137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 18.2517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.2519551842 19833225 19090486 19642983 19690152 20118626 19426721 2862719 18977376 19812893 18978307 21047994 18644402 19256749 19850985 20501860 20434301 19427195 19294768 20452335 15175105 19499222 19254457 21167192 18754104 19073162 20101389 19638242 18648771 20492335 2422723 19255062 9163691 16942905 12771043 21071580 10737359 15885732 20137499 20405173 21278145 19996281 12112319 20583210
MESH:D008113 Liver Neoplasms pirinixic acid 18.2520007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.042876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.041399818 6587162 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.0417854601 18164116 17174075 18093689 21159647 16842330 16267830 9362446 19539802 19004024 18775883 3124819 19009564 17942915 2563599 18308698 18253720 19519916 19126423 18544905 18282651 18079962
MESH:D008175 Lung Neoplasms Arsenic 4.9517976673 17306315 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9520464547 20064080 18816296 18520028 20869020 20135361 6695378 18569708 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.9520970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Zidovudine 4.9518800350
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.9317358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009164 Mycobacterium Infections Indinavir 5.5121442799
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Arsenic 4.0315371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9418551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.773581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.773581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.496679447
MESH:D009436 Neural Tube Defects Arsenic 7.4916620997
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3920387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.4317056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.4616049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.464026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.4614694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010051 Ovarian Neoplasms Arsenic 2.7617306315
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4416540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.076392382 16905509 15371236
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.602563599
MESH:D011471 Prostatic Neoplasms Arsenic 3.2916140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2917292933
MESH:D011507 Proteinuria Arsenic 4.0621343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012206 Rhabdomyolysis Lamivudine 5.629296927
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5718551238
MESH:D012871 Skin Diseases Arsenic 2.7618709164 16353154 19834688 17938729 16759981 6392382 17548696 17050553 16702368 17453740 15952646
MESH:D012878 Skin Neoplasms Arsenic 5.9117050553 15504454 17029826 19538983 17976673 16251483
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.442093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4418456281
MESH:D013274 Stomach Neoplasms Zidovudine 3.4417696246
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.267505956 1399818 6587162 6582329 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.267505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.1016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.108074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 12.1011144890 18640142 19322015 17306315 15987713 19429237 17976673
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.1017053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D014625 Vaginal Neoplasms Zidovudine 4.8312579204
MESH:D014652 Vascular Diseases Arsenic 4.8217056641
Pathway ID Pathway Name
REACT:6185 HIV Infection
REACT:474 Metabolism of carbohydrates
KEGG:03013 RNA transport
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394614
    • No data
    Releated disease ID Related disease Name
    PA446847Arrhythmogenic Right Ventricular Dysplasia
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved