AutismKB 2.0

Annotation Detail for VPS13A


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Basic Information Top
Gene Symbol:VPS13A ( CHAC,CHOREIN,FLJ42030,KIAA0986 )
Gene Full Name: vacuolar protein sorting 13 homolog A (S. cerevisiae)
Band: 9q21.2
Quick LinksEntrez ID:23230; OMIM: 605978; Uniprot ID:VP13A_HUMAN; ENSEMBL ID: ENSG00000197969; HGNC ID: 1908
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of VPS13A mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of VPS13A mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of VPS13A mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VPS13A mRNAdecreases expression 19150397
D003010 Clorgyline Clorgyline results in increased expression of VPS13A mRNAincreases expression 19691856
D008345 Manganese Manganese results in decreased expression of VPS13A mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of VPS13A mRNAdecreases expression 17175027
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D000756 Anemia, Sideroblastic Manganese 11.9916910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.9916910769
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6516393943 11287661 12540782 14725611 11421492 12153990 19923254 10663392 17522070 17906064 11529661 16781746 2444490 10915739 10774834 19416960 15619225 18071297 16081117 11461765 14550746 18713872 16485898 19739265 16109766 12705907 19085960 14986274 19370779 12392966 12594235 16177239 16227642 11739529 19164858 17562736 11743745 15968718 19420014 12958197 11834606
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005909 Glioblastoma Manganese 4.0817043766
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D008107 Liver Diseases Acetaminophen 1.6816610002 19460945 19014921 12587719 19784758 11587558 16611625 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1220195826 21137059
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5717053015 6695378 18520028 18816296 20464547 20064080 20135361 18569708 20869020
MESH:D020149 Manganese Poisoning Manganese 5.9616551646 19453300 16568477
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009069 Movement Disorders Manganese 5.3116551646
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009410 Nerve Degeneration Manganese 4.4816551646
MESH:D054546 Neuroacanthocytosis marker/mechanism
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010300 Parkinson Disease Manganese 3.4511181820
MESH:D020734 Parkinsonian Disorders Manganese 4.7316140633
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.4917292933
MESH:D011471 Prostatic Neoplasms Clorgyline 3.4919691856
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4819755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2617053015
MESH:D014581 Urticaria Acetaminophen 3.2810982225
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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