AutismKB 2.0

Annotation Detail for EXOC6B


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Basic Information Top
Gene Symbol:EXOC6B ( KIAA0919,SEC15B,SEC15L2 )
Gene Full Name: exocyst complex component 6B
Band: 2p13.2
Quick LinksEntrez ID:23233; OMIM: 607880; Uniprot ID:EXC6B_HUMAN; ENSEMBL ID: ENSG00000144036; HGNC ID: 17085
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
C006253 pirinixic acid pirinixic acid results in increased expression of EXOC6B mRNAincreases expression 18301758
D014212 Tretinoin Tretinoin results in increased expression of EXOC6B mRNAincreases expression 18230668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.7218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.3716434500
MESH:D000505 Alopecia Tretinoin 4.0215955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.3516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3416292516
MESH:D001249 Asthma Tretinoin 2.4516456186
MESH:D001471 Barrett Esophagus Tretinoin 5.0816935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.8719483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.8716197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.4816813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 6.2316168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.921917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3916051514 16096774
MESH:D002386 Cataract Tretinoin 3.3417460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.4816129372
MESH:D002779 Cholestasis pirinixic acid 3.1919176532
MESH:D002822 Choriocarcinoma Tretinoin 6.2316461808
MESH:D002972 Cleft Palate Tretinoin 2.839407595
MESH:D003092 Colitis Tretinoin 4.4717035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.838800419 9211117 10589399 14991402 17551590 9125849 16925845 9664655 9224671 9142499
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.6118249437
MESH:D004487 Edema pirinixic acid 3.0212083418
MESH:D004489 Edema, Cardiac Tretinoin 5.5418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.4016569247
MESH:D005124 Eye Abnormalities Tretinoin 3.9416938888 9664655
MESH:D005234 Fatty Liver pirinixic acid 3.3119236843 20131406
MESH:D005355 Fibrosis Tretinoin 4.2717994277
MESH:D005909 Glioblastoma Tretinoin 3.3017312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 6.2316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.119664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.8120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.7618467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia Tretinoin 3.6216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.3316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.6920558911
MESH:D007333 Insulin Resistance pirinixic acid 2.9316306350
MESH:D007410 Intestinal Diseases Tretinoin 4.5317994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.4517551590 15992940
MESH:D007938 Leukemia Tretinoin 2.9717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.2516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1316294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.4519075265 17107899 16788101 16891316 19225113 17339181 15748426 17712046 16331271 17217047 16766008 17294898 16935935 19035177 17301526 16823087 12679006 19642359 19029980 17649720 17506722 9834237 17368321 16140955 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.659224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4518397230 16248980
MESH:D008113 Liver Neoplasms pirinixic acid 1.9515890375 16377806 20007298
MESH:D008527 Medulloblastoma Tretinoin 2.9317453147
MESH:D008545 Melanoma Tretinoin 1.9916752155
MESH:D008591 Meningomyelocele Tretinoin 5.1916940565
MESH:D009135 Muscular Diseases pirinixic acid 4.2716239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.3217596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.3019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.3316411023
MESH:D009369 Neoplasms pirinixic acid 5.5917405874
MESH:D009369 Neoplasms Tretinoin 5.5916594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.459125849
MESH:D009436 Neural Tube Defects Tretinoin 3.359142499
MESH:D009765 Obesity pirinixic acid 1.9020558911
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4616936753
MESH:D010146 Pain Tretinoin 3.3316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5915976015
MESH:D011507 Proteinuria Tretinoin 4.2116636307
MESH:D011625 Pterygium Tretinoin 5.6816723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.5819058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.7116116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.7916467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.4016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.2916051514
MESH:D014376 Tuberculosis Tretinoin 3.5016040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.1816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.6816752155
MESH:D014820 Vitiligo Tretinoin 4.7316761959
MESH:D009396 Wilms Tumor Tretinoin 4.4416287080
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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