AutismKB 2.0

Annotation Detail for PLCB1


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Basic Information Top
Gene Symbol:PLCB1 ( FLJ45792,PI-PLC,PLC-154,PLC-I,PLC154 )
Gene Full Name: phospholipase C, beta 1 (phosphoinositide-specific)
Band: 20p12.3
Quick LinksEntrez ID:23236; OMIM: 607120; Uniprot ID:PLCB1_HUMAN; ENSEMBL ID: ENSG00000182621; HGNC ID: 15917
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6367D-myo-inositol-5-phosphate metabolism
LIPASYN-PWYphospholipases
PWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04720Long-term potentiation
hsa04020Calcium signaling pathway
hsa05142Chagas disease
hsa05146Amoebiasis
hsa04310Wnt signaling pathway
hsa04540Gap junction
hsa04730Long-term depression
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa04971Gastric acid secretion
hsa01100Metabolic pathways
hsa04062Chemokine signaling pathway
hsa04070Phosphatidylinositol signaling system
Pathway IDPathway Name
Signaling by GPCR
Synaptic Transmission
Diabetes pathways
Opioid Signalling
Integration of energy metabolism
No data
Pathway IDPathway Name
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P00019Endothelin signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P05730Endogenous cannabinoid signaling
P00002Alpha adrenergic receptor signaling pathway
P057262-arachidonoylglycerol biosynthesis
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
Cognitive performance
Desease Name
Cognitive test performance
Cognitive performance
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PLCB1 mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PLCB1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PLCB1 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PLCB1 proteinaffects expression 20106945
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]decreases reaction|increases expression 19225867
D001151 Arsenic Arsenic results in decreased expression of PLCB1 mRNAdecreases expression 19654921
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PLCB1 mRNAaffects cotreatment|decreases expression 15894712
C015001 arsenite arsenite results in increased expression of PLCB1 mRNAincreases expression 15894712
D001374 Azacitidine Azacitidine results in decreased methylation of PLCB1 promoterdecreases methylation 19805378
D001374 Azacitidine Azacitidine results in increased expression of PLCB1 mRNAincreases expression 19805378
D001374 Azacitidine Azacitidine results in increased expression of PLCB1 proteinincreases expression 19805378
D001374 Azacitidine PLCB1 mRNA results in increased susceptibility to Azacitidineincreases response to substance 19805378
D001374 Azacitidine PLCB1 promoter modified form results in decreased susceptibility to Azacitidinedecreases response to substance 19805378
D001374 Azacitidine PLCB1 protein results in increased susceptibility to Azacitidineincreases response to substance 19805378
D001464 Barium [DRD2 protein results in increased activity of PLCB1 protein] which results in decreased transport of Bariumdecreases transport|increases activity 11124974
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PLCB1 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PLCB1 mRNAaffects cotreatment|decreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PLCB1 mRNAdecreases expression 15894712
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PLCB1 mRNAdecreases expression 20382639
D003024 Clozapine Clozapine results in increased expression of PLCB1 mRNAincreases expression 16465460
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PLCB1 mRNAincreases expression 19371625
D015025 Zearalenone Zearalenone results in increased expression of PLCB1 mRNAincreases expression 19371625
D019833 Genistein Genistein results in increased expression of PLCB1 mRNAincreases expression 19371625
D009151 Mustard Gas Mustard Gas affects the expression of PLCB1 mRNAaffects expression 15651846
D009638 Norepinephrine anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]decreases reaction|increases expression 19225867
D009638 Norepinephrine Norepinephrine results in increased expression of and results in increased activity of PLCB1 proteinincreases activity|increases expression 19225867
D009638 Norepinephrine Norepinephrine results in increased expression of PLCB1 mRNAincreases expression 19225867
D009638 Norepinephrine Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein]decreases reaction|increases activity|increases expression 19225867
D009638 Norepinephrine Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]decreases reaction|increases expression 19225867
D010121 Oxytocin Oxytocin affects the localization of PLCB1 proteinaffects localization 11579162
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of PLCB1 mRNAincreases expression 17681415
D010665 Phenylpropanolamine Phenylpropanolamine results in increased expression of PLCB1 mRNAincreases expression 16465460
C006253 pirinixic acid pirinixic acid results in increased expression of PLCB1 mRNAincreases expression 18301758
D011224 Prazosin Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein]decreases reaction|increases activity|increases expression 19225867
D011224 Prazosin Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]decreases reaction|increases expression 19225867
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PLCB1 mRNAdecreases expression 17101203
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7015322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2920127859 20464547
MESH:D000230 Adenocarcinoma Genistein 4.2911473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.576695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3916835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0617306315
MESH:D000380 Agranulocytosis Clozapine 4.9014617031 16160616 12649775
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3315469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000855 Anorexia Phenylpropanolamine 5.5917684035
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8316835338 12569548 16251483 18414634
MESH:D001249 Asthma Mustard Gas 2.6710378619
MESH:D050197 Atherosclerosis Arsenic 3.1619371607 12928151
MESH:D001321 Autistic Disorder Norepinephrine 3.618570775
MESH:D001321 Autistic Disorder Oxytocin 3.6116904652
MESH:D001768 Blister Mustard Gas 5.0119167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9320146248 17474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9317129689 15324884
MESH:D001943 Breast Neoplasms Genistein 1.9316873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.8310378619 17687719
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5117687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.7216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.7216705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.7212619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 13.7219418558
MESH:D006528 Carcinoma, Hepatocellular Arsenic 13.7216507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.7216924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.7216924424
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.5717687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5720419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.9418640142
MESH:D006332 Cardiomegaly Norepinephrine 6.9111179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9118850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 7.1617938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Genistein 7.1616332659
MESH:D002340 Carotid Artery Diseases Arsenic 4.1818022660 16973168
MESH:D002375 Catalepsy Norepinephrine 5.398216760
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.306135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.3020889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002779 Cholestasis pirinixic acid 2.7119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0415668235 15340226 12621046 8697196 16354765
MESH:D003072 Cognition Disorders Clozapine 4.8117123785
MESH:D003110 Colonic Neoplasms arsenite 3.8915037631
MESH:D003110 Colonic Neoplasms Genistein 3.8917182828
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.4116002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.3918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.3918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.9916402076
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.9916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9917107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.4015331141
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.6721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.6721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Prazosin 8.6718071297
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.6720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D050171 Dyslipidemias Clozapine 4.0816402076
MESH:D004487 Edema Mustard Gas 15.3211428647 11428631 11402378 9260866
MESH:D004487 Edema perfluorooctanoic acid 15.3217259670 12083418
MESH:D004487 Edema pirinixic acid 15.3212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.3211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.3816402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.3816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.3616804899 15700306
MESH:D016889 Endometrial Neoplasms Genistein 7.3611473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.899294722 10568697
MESH:D004827 Epilepsy Norepinephrine 4.22821787
MESH:D004890 Erythema Mustard Gas 5.019357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver arsenite 7.4418296743
MESH:D005234 Fatty Liver pirinixic acid 7.4420131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5615751030 16513791 16534752 16002989 16611131
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005355 Fibrosis arsenite 8.3218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3220067830
MESH:D005534 Foot Diseases Arsenic 5.416392382
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7916452187
MESH:D005909 Glioblastoma Genistein 3.1616598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 13.593609246
MESH:D006529 Hepatomegaly pirinixic acid 13.5916221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.5915340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8915340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia perfluorooctanoic acid 8.2612083418
MESH:D006930 Hyperalgesia Prazosin 8.2612727271
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3217050553
MESH:D006948 Hyperkinesis Clozapine 4.7616046005
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2914722030 12960047
MESH:D006973 Hypertension Arsenic 5.0416076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.4116093927
MESH:D007021 Hypospadias Diethylstilbestrol 4.4316002989
MESH:D007022 Hypotension Norepinephrine 4.856740701
MESH:D007246 Infertility Diethylstilbestrol 4.2115036965
MESH:D007249 Inflammation Mustard Gas 7.9611428647 11428620 11402378 9260866 8975870 11428631 16001271 9357497 17524151
MESH:D007249 Inflammation perfluorooctanoic acid 7.9612083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.9612200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.5316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007642 Keratosis Arsenic 4.8416930632 12749816
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.7415003126 14681315 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9117184923
MESH:D007938 Leukemia Azacitidine 6.5019148494
MESH:D007938 Leukemia Genistein 6.5018980019 17468513
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 5.2216972261
MESH:D007951 Leukemia, Myeloid Azacitidine 4.4819077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 2.9718720364 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.0519299654
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4517339181
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.088812269
MESH:D008064 Lipidoses Clozapine 3.8517567588
MESH:D008103 Liver Cirrhosis arsenite 3.3418296743
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.3317823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3312878042
MESH:D008107 Liver Diseases Arsenic 2.5111134558
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 24.987678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.982125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Arsenic 24.9816368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.9820195826 21137059
MESH:D008113 Liver Neoplasms Diethylstilbestrol 24.9815890375 16712894
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 24.9814757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 24.9820007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.9816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.256135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.258603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.2512151625
MESH:D008171 Lung Diseases Mustard Gas 3.3518161513 18702808
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.4214755239
MESH:D008175 Lung Neoplasms Arsenic 10.4217306315 19168569 17976673
MESH:D008175 Lung Neoplasms arsenite 10.4216809336
MESH:D008175 Lung Neoplasms Azacitidine 10.4221224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.4220869020 18816296 18520028 18569708 20064080 6695378 17053015 20135361 20464547
MESH:D008175 Lung Neoplasms Mustard Gas 10.423148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.4211884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3616002989
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.8512929590 14578162
MESH:D001523 Mental Disorders Clozapine 3.8016856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.2919142101
MESH:D009006 Monosomy Azacitidine 5.9319299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0716381670
MESH:D009101 Multiple Myeloma Azacitidine 3.8619549372 18443271
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009190 Myelodysplastic Syndromes marker/mechanism 19805378
MESH:D009190 Myelodysplastic Syndromes Azacitidine 3.9218720364 19805378 17611569 17596541
MESH:D009203 Myocardial Infarction Genistein 5.4717141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.4719151258
MESH:D017202 Myocardial Ischemia Arsenic 8.6015371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.6012213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.7117141266
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 13.7115642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.7116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.8418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.847678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 7.8111141357
MESH:D009369 Neoplasms Diethylstilbestrol 7.8115313581
MESH:D009369 Neoplasms pirinixic acid 7.8117405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.2615738583
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.5811399458
MESH:D009421 Nervous System Malformations Genistein 15.5816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5814600291
MESH:D009436 Neural Tube Defects Arsenic 3.3616620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.2317056641
MESH:D009503 Neutropenia Mustard Gas 3.8316761898 7688884
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.809802331
MESH:D009765 Obesity Clozapine 4.5718515891 19142110
MESH:D009765 Obesity pirinixic acid 4.5720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.4412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.4416049721
MESH:D010024 Osteoporosis Genistein 3.1619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9416169203
MESH:D010051 Ovarian Neoplasms Arsenic 4.9317306315
MESH:D010051 Ovarian Neoplasms Genistein 4.9319005980
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0316093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.8415371236 6392382 16905509
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5215687265 16977796
MESH:D011041 Poisoning Mustard Gas 3.6615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 15.4617184923
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 15.4617132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.4611222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Arsenic 1.9016140617
MESH:D011471 Prostatic Neoplasms Azacitidine 1.9018324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9015046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Genistein 1.9015378649 15256057 16925846
MESH:D011507 Proteinuria Arsenic 3.8621343184
MESH:D011537 Pruritus Mustard Gas 3.9418058305
MESH:D011618 Psychotic Disorders Clozapine 4.0815331141
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8717620002 17894541 17266442 10334151 17720292
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012559 Schizophrenia marker/mechanism 17667964
MESH:D012559 Schizophrenia Clozapine 2.7211151749 17726453 11763009 18855531 17667964 20168265 19369910 20521326 16141801 20107430 20521320 20580759 18806925 20452607 17123785
MESH:D012640 Seizures 2,4-dinitrotoluene 5.5318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.5318551238
MESH:D012871 Skin Diseases Arsenic 5.0119834688 16702368 15952646 16759981 17050553 6392382 18709164 17938729 17453740 17548696 16353154
MESH:D012871 Skin Diseases Mustard Gas 5.0116961503 12880345 15451306
MESH:D012878 Skin Neoplasms Arsenic 9.0317050553 17976673 16251483 17029826 15504454 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.0310029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0316192470
MESH:D013088 Spermatocele Diethylstilbestrol 4.5616709447 16002989
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.552093021 20155912
MESH:D013610 Tachycardia Norepinephrine 5.293261545
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.1816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.1816049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 15.1811144890 17306315 18640142 15987713 19429237 19322015 17976673
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.1817053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 15.1816712894 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.4810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.4810091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.9016175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.9216690809 15809267
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2916513791 16002989
MESH:D014652 Vascular Diseases Arsenic 4.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D015430 Weight Gain Clozapine 4.3420521320 16141801 17502770 20107430 20564506 16402076
MESH:D015431 Weight Loss Clozapine 4.9217933447
Pathway ID Pathway Name
KEGG:05143 African trypanosomiasis
KEGG:05010 Alzheimer's disease
KEGG:05146 Amoebiasis
KEGG:04020 Calcium signaling pathway
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:04062 Chemokine signaling pathway
REACT:15380 Diabetes pathways
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
KEGG:05016 Huntington's disease
KEGG:00562 Inositol phosphate metabolism
REACT:1505 Integration of energy metabolism
KEGG:04730 Long-term depression
KEGG:04720 Long-term potentiation
KEGG:04916 Melanogenesis
KEGG:01100 Metabolic pathways
REACT:15295 Opioid Signalling
KEGG:04972 Pancreatic secretion
KEGG:04070 Phosphatidylinositol signaling system
KEGG:04970 Salivary secretion
REACT:33891 Signaling by GPCR
REACT:14797 Signaling by GPCR
REACT:13685 Synaptic Transmission
KEGG:04270 Vascular smooth muscle contraction
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33384
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    PA443450Asthma
    Releated drug ID Related drug Name
    PA448497aspirin
    PA448478l-arginine
    PA450635nitric oxide
    PA164743471adenosine triphosphate
    PA449396dopamine
    PA449345dinoprostone
    PA449479epoprostenol
    PA164712740Epoxides
    PA450631nifedipine
    PA164712535Beta Blocking Agents
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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