AutismKB 2.0

Annotation Detail for ARC


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ARC ( Arg3.1,KIAA0278 )
Gene Full Name: activity-regulated cytoskeleton-associated protein
Band: 8q24.3
Quick LinksEntrez ID:23237; OMIM: 612461; Uniprot ID:ARC_HUMAN; ENSEMBL ID: ENSG00000198576; HGNC ID: 648
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C432168 1-(1-dimethylaminomethyl-5-methoxybenzocyclobutan-1-yl)cyclohexanol 1-(1-dimethylaminomethyl-5-methoxybenzocyclobutan-1-yl)cyclohexanol results in increased expression of ARC mRNAincreases expression 15838995
C432168 1-(1-dimethylaminomethyl-5-methoxybenzocyclobutan-1-yl)cyclohexanol 1-(1-dimethylaminomethyl-5-methoxybenzocyclobutan-1-yl)cyclohexanol results in increased expression of ARC proteinincreases expression 15087240
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in decreased expression of ARC proteindecreases expression 18503570
D000082 Acetaminophen Acetaminophen affects the expression of ARC mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of ARC mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ARC mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine affects the expression of ARC mRNAaffects expression 17049170
19222557
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of ARC mRNAincreases expression 17499349
D000661 Amphetamine Amphetamine results in decreased expression of ARC mRNAdecreases expression 15183010
D000661 Amphetamine Amphetamine results in increased expression of ARC mRNAincreases expression 20223277
11879792
12638131
D000661 Amphetamine Amphetamine results in increased expression of ARC proteinincreases expression 14596895
D003024 Clozapine Clozapine results in decreased expression of ARC mRNAdecreases expression 18208916
D003891 Desipramine Desipramine results in increased expression of ARC mRNAincreases expression 14580947
D004041 Dietary Fats Dietary Fats results in decreased expression of ARC mRNAdecreases expression 18503570
D004041 Dietary Fats Dietary Fats results in decreased expression of ARC proteindecreases expression 18503570
D004958 Estradiol Estradiol results in decreased expression of ARC mRNAdecreases expression 20068009
D004958 Estradiol Estradiol results in increased expression of ARC mRNAincreases expression 19420261
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARC mRNAaffects cotreatment|increases expression 17942748
D005665 Furosemide Furosemide affects the expression of ARC mRNAaffects expression 17497460
D006220 Haloperidol 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of ARC mRNA]decreases reaction|increases expression 19695244
D006220 Haloperidol Haloperidol results in increased expression of ARC mRNAincreases expression 19695244
18208916
D007530 Isoflurane Isoflurane results in decreased expression of ARC mRNAdecreases expression 16978161
D008694 Methamphetamine Methamphetamine results in increased expression of ARC mRNAincreases expression 11085305
D008694 Methamphetamine SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ARC mRNA]decreases reaction|increases expression 11085305
C004925 methylmercuric chloride methylmercuric chloride results in increased expression of ARC mRNAincreases expression 19465457
C030589 methylmercury cysteine methylmercury cysteine results in increased expression of ARC mRNAincreases expression 19465457
D008774 Methylphenidate Methylphenidate affects the expression of ARC mRNAaffects expression 19222557
C521676 N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine results in increased expression of ARC mRNAincreases expression 19695244
D017371 8-Hydroxy-2-(di-n-propylamino)tetralin 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of ARC mRNA]decreases reaction|increases expression 19695244
D017374 Paroxetine Paroxetine results in increased expression of ARC mRNAincreases expression 14580947
D011374 Progesterone Progesterone results in decreased expression of ARC mRNAdecreases expression 16376865
C534628 SCH 23390 SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ARC mRNA]decreases reaction|increases expression 11085305
C009250 sevoflurane sevoflurane affects the expression of ARC mRNAaffects expression 15967596
D013629 Tamoxifen Tamoxifen results in decreased expression of ARC mRNAdecreases expression 19420261
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARC mRNAaffects cotreatment|increases expression 17942748
D015647 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of ARC mRNAincreases expression 17499349
D013849 Thimerosal Thimerosal results in increased expression of ARC mRNAincreases expression 16870260
D014191 Tranylcypromine Tranylcypromine results in increased expression of ARC mRNAincreases expression 14580947
C047426 venlafaxine venlafaxine results in increased expression of ARC mRNAincreases expression 15838995
14580947
C047426 venlafaxine venlafaxine results in increased expression of ARC proteinincreases expression 15087240
C025643 vinclozolin vinclozolin affects the expression of ARC mRNAaffects expression 19015723
C090413 WAY 100635 WAY 100635 results in increased expression of ARC mRNAincreases expression 19695244
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2214745880
MESH:D000014 Abnormalities, Drug-Induced methylmercuric chloride 7.696734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.6914514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6117505938
MESH:D000230 Adenocarcinoma Estradiol 3.9211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9214692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0516835633
MESH:D000380 Agranulocytosis Clozapine 4.7414617031 12649775 16160616
MESH:D000544 Alzheimer Disease marker/mechanism 18503570
MESH:D000544 Alzheimer Disease 27-hydroxycholesterol 3.6520157255 14523054
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.7318475255 15010207 16459022 16916582
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D000799 Angioedema Acetaminophen 3.5110982225
MESH:D000855 Anorexia 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine 9.9412183048
MESH:D000855 Anorexia Amphetamine 9.9412183048 16084549 16101753 12005258
MESH:D001008 Anxiety Disorders vinclozolin 3.3919015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5218057881 20041841 18218290
MESH:D001161 Arteriosclerosis Dietary Fats 8.8515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.8511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4615885639
MESH:D050197 Atherosclerosis 27-hydroxycholesterol 4.249059518 11166758
MESH:D001281 Atrial Fibrillation Amiodarone 3.6618651412 19698954
MESH:D001289 Attention Deficit Disorder with Hyperactivity Methylphenidate 5.2210490706 16919137 17276750
MESH:D001321 Autistic Disorder Acetaminophen 2.4218445737
MESH:D001321 Autistic Disorder Haloperidol 2.4218080171 19368416
MESH:D001321 Autistic Disorder Methylphenidate 2.4218752063 19232924 16919137
MESH:D001778 Blood Coagulation Disorders Amiodarone 8.0819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0117868700
MESH:D001930 Brain Injuries Progesterone 3.9415845082 15380490 15665606
MESH:D001943 Breast Neoplasms Dietary Fats 2.2220435547
MESH:D001943 Breast Neoplasms Estradiol 2.2214630087 16675129 17261762 17289903 19861407 12948864 17018787 18497071
MESH:D001943 Breast Neoplasms Progesterone 2.2217614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 2.2218855134 18821012 19142967 17261762 19189210 19200415 16202921 18629630 19084267 11161223 19011961 20135344 18351453 19059307 15668708 19289846 19189212 18984771 17440819 16273361 20544844 19103187 19487384 19066611 19221464 20005174 20859285 21152245 19410462 18997820 18815881 18425577 16873071 20065188 15565566 19244106 19115204 16818667 17049068 20390343 17893378 19155303 19288272 17242785 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1416111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1919066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.193084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.1916924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.1916924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1918850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7815710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7618974383
MESH:D002375 Catalepsy Haloperidol 4.581977408 15215559
MESH:D002386 Cataract Acetaminophen 2.3910977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.5518566989
MESH:D002659 Child Development Disorders, Pervasive Methylphenidate 4.6818752063 15319018
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6411677210 17681005 17333356 16919318 15861022 16105132 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.978697196 15668235 15340226 12621046 16354765
MESH:D019970 Cocaine-Related Disorders Methylphenidate 6.1719462300
MESH:D003072 Cognition Disorders Clozapine 4.6517123785
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7917141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2420055451 10048152 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.0314966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.5420210726
MESH:D003704 Dementia Haloperidol 4.2911575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0419031437
MESH:D003715 Dengue 27-hydroxycholesterol 5.3619427377
MESH:D003866 Depressive Disorder Desipramine 12.253690436 15014590
MESH:D003866 Depressive Disorder Paroxetine 12.2517072103 15014590
MESH:D003866 Depressive Disorder venlafaxine 12.2520305041
MESH:D017449 Dermatitis, Allergic Contact Thimerosal 4.2316958921 15932584
MESH:D002658 Developmental Disabilities Thimerosal 4.6215764492
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.2216402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2217107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.9419279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.9419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1717187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.2215331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.5718071297 2444490 14550746 11421492 11743745 16485898 12540782 10663392 12705907 11834606 18713872 16393943 11739529 12153990 17906064 17562736 11461765 19420014 16109766 12594235 16781746 19164858 14725611 11529661 10915739 19370779 16081117 12392966 19739265 17522070 11287661 19923254 19416960 14986274 15968718 16227642 19085960 12958197 16177239 15619225 10774834
MESH:D056486 Drug-Induced Liver Injury Amiodarone 5.5718218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.5720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D004409 Dyskinesia, Drug-Induced 8-Hydroxy-2-(di-n-propylamino)tetralin 11.8115893579
MESH:D004409 Dyskinesia, Drug-Induced Desipramine 11.813690436
MESH:D050171 Dyslipidemias Clozapine 8.0916402076
MESH:D050171 Dyslipidemias Dietary Fats 8.0918367378
MESH:D004417 Dyspnea Furosemide 4.6116935035
MESH:D004487 Edema Furosemide 6.1511834646
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 27-hydroxycholesterol 19.4417410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 19.4412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 19.4417692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.4419031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.6818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.6816202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Progesterone 8.0016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.0010568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005221 Fatigue Amphetamine 5.2719890266
MESH:D005234 Fatty Liver Amiodarone 16.4114986274
MESH:D005234 Fatty Liver Dietary Fats 16.4117967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.4115345470
MESH:D005234 Fatty Liver Tamoxifen 16.4119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8619069698
MESH:D005355 Fibrosis Dietary Fats 7.5718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.5720067830
MESH:D005756 Gastritis Acetaminophen 3.3416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6116973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9716417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D034381 Hearing Loss Furosemide 4.5617868369
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1610048152 11294989
MESH:D006333 Heart Failure Furosemide 3.8616011733 12660669 16845234
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006529 Hepatomegaly Amiodarone 7.4815265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.4812621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7015709030
MESH:D019584 Hot Flashes Estradiol 15.5917088409
MESH:D019584 Hot Flashes Paroxetine 15.5914716179
MESH:D019584 Hot Flashes venlafaxine 15.5914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7116354765 8697196 18606429 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.4516870215
MESH:D006934 Hypercalcemia Furosemide 4.7817652376
MESH:D053565 Hypercalciuria Furosemide 5.3317652376
MESH:D006937 Hypercholesterolemia 27-hydroxycholesterol 13.8217873880
MESH:D006937 Hypercholesterolemia Amiodarone 13.828137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 13.8221332399
MESH:D006948 Hyperkinesis Amphetamine 17.431977408 14960337
MESH:D006948 Hyperkinesis Clozapine 17.4316046005
MESH:D006948 Hyperkinesis Methamphetamine 17.4317658665
MESH:D006949 Hyperlipidemias Dietary Fats 3.3221332399
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.5415086907
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7818850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 4.9716612254
MESH:C537153 Hypomagnesemia primary Furosemide 5.3311041285
MESH:D007019 Hypoproteinemia Furosemide 5.5416096441
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4916569931 16945680
MESH:D007022 Hypotension Furosemide 8.8711041285
MESH:D007022 Hypotension Isoflurane 8.8712967683
MESH:D007024 Hypotension, Orthostatic Furosemide 5.0915811171
MESH:D007037 Hypothyroidism Amiodarone 4.2017991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.9417937319
MESH:D007248 Infertility, Male vinclozolin 5.9416467254
MESH:D007249 Inflammation Dietary Fats 10.5320412841
MESH:D007249 Inflammation Progesterone 10.5315869954
MESH:D007249 Inflammation Tamoxifen 10.5319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.5312200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 6.6611836018 18457598
MESH:D007333 Insulin Resistance Estradiol 6.6616627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0516580747
MESH:D007674 Kidney Diseases Acetaminophen 9.0715629191 12587719
MESH:D007674 Kidney Diseases Estradiol 9.0715618244
MESH:D007674 Kidney Diseases Furosemide 9.0711041285
MESH:D007680 Kidney Neoplasms Estradiol 6.5215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.5218625569
MESH:D007859 Learning Disorders sevoflurane 4.4619212262
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4116417039
MESH:D008064 Lipidoses Amiodarone 11.8917567588 15342952
MESH:D008064 Lipidoses Clozapine 11.8917567588
MESH:D008064 Lipidoses Tamoxifen 11.8917567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.7018296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.2014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.2018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.2012878042
MESH:D008107 Liver Diseases Acetaminophen 1.5516610002 12969438 11587558 16611625 19784758 19460945 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 9.1016871587 17185352
MESH:D017114 Liver Failure, Acute venlafaxine 9.1019857765
MESH:D008113 Liver Neoplasms Tamoxifen 3.9716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 3.9716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.9112151625
MESH:D008133 Long QT Syndrome Amiodarone 3.3311989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.1612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1518516814
MESH:D008175 Lung Neoplasms Tamoxifen 2.1418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.1419555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4419428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.7611408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.7617203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.7611731420 14580682 19196722 16827153 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.5419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.5419453300
MESH:D008545 Melanoma Tamoxifen 1.8419393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2519513568
MESH:D008569 Memory Disorders sevoflurane 4.4419212262
MESH:D001523 Mental Disorders Clozapine 21.1116856516
MESH:D001523 Mental Disorders Desipramine 21.1116856516
MESH:D001523 Mental Disorders Haloperidol 21.1116856516
MESH:D001523 Mental Disorders Paroxetine 21.1116856516
MESH:D001523 Mental Disorders venlafaxine 21.1116856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.1519142101
MESH:D008881 Migraine Disorders venlafaxine 4.5418803445
MESH:D009041 Motion Sickness Dextroamphetamine 5.191613127
MESH:D009181 Mycoses Amiodarone 4.5717974566 12754197
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0316810080
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6719196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4117289903
MESH:D009397 Nephrocalcinosis Furosemide 5.5415086907
MESH:D009421 Nervous System Malformations Estradiol 8.4411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7918514411
MESH:D019636 Neurodegenerative Diseases Amphetamine 7.7915183010
MESH:D053206 Nocturnal Enuresis Furosemide 5.5417945291
MESH:D009765 Obesity Clozapine 4.5818515891 19142110
MESH:D009765 Obesity Dietary Fats 4.5821332399 17217161 16723640 11836018 18457598 20132043 20518802 19632207 18674790
MESH:D009771 Obsessive-Compulsive Disorder Paroxetine 10.9217503984
MESH:D009771 Obsessive-Compulsive Disorder venlafaxine 10.9217503984
MESH:D010051 Ovarian Neoplasms Estradiol 4.5119401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.5116525653 17393432
MESH:D010146 Pain Acetaminophen 2.1416870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D010300 Parkinson Disease Desipramine 4.2610965161
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D010538 Peritonitis Isoflurane 4.9117414419
MESH:D011141 Polyuria Furosemide 5.3317945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4011896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.4018042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.6118220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.3016740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3015067354
MESH:D011472 Prostatitis vinclozolin 4.6118629315
MESH:D011537 Pruritus Ethinyl Estradiol 2.9916919318 15861022
MESH:D011595 Psychomotor Agitation Haloperidol 11.0211575062
MESH:D011595 Psychomotor Agitation Methylphenidate 11.0218752063
MESH:D011618 Psychotic Disorders Clozapine 8.3815331141
MESH:D011618 Psychotic Disorders Haloperidol 8.3811575062
MESH:D011649 Pulmonary Alveolar Proteinosis 27-hydroxycholesterol 6.0615466366
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7311597910 12490602 12832656
MESH:D015427 Reperfusion Injury Furosemide 3.7516526316
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.3216096441 12394941 15912074
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D012559 Schizophrenia Clozapine 3.9217726453 16141801 18855531 20168265 20107430 17667964 20580759 19369910 20452607 20521320 11151749 18806925 17123785 11763009 20521326
MESH:D012559 Schizophrenia Haloperidol 3.921830565 20107430 19369910 18513383
MESH:D018805 Sepsis Isoflurane 4.7317414419
MESH:D020230 Serotonin Syndrome Methylphenidate 6.307854515
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7618724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.8916192470
MESH:D019082 Smith-Lemli-Opitz Syndrome 27-hydroxycholesterol 5.7011254748
OMIM:270800 SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE 27-hydroxycholesterol 6.0519812052
MESH:D013088 Spermatocele Ethinyl Estradiol 10.4616709447
MESH:D013088 Spermatocele Tamoxifen 10.4616709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.7916503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.7919457130
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.091977408
MESH:D013274 Stomach Neoplasms Furosemide 2.8517052386
MESH:D013276 Stomach Ulcer Amiodarone 3.0418087811
MESH:D013610 Tachycardia Amiodarone 3.9811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 9.5019225199
MESH:D017180 Tachycardia, Ventricular Haloperidol 9.5020210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8815669648
MESH:D013959 Thyroid Diseases Amiodarone 10.9519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.9512697716
MESH:D013971 Thyrotoxicosis Amiodarone 4.5418020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.3519048282
MESH:D016171 Torsades de Pointes Amiodarone 3.8717467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.2317572228 16712894 8653321
MESH:D014581 Urticaria Acetaminophen 2.6810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D015430 Weight Gain Clozapine 8.9220107430 16141801 17502770 20521320 20564506 16402076
MESH:D015430 Weight Gain Dietary Fats 8.9216723640
MESH:D015431 Weight Loss Clozapine 4.7517933447
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved