AutismKB 2.0

Annotation Detail for ASTN2


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Basic Information Top
Gene Symbol:ASTN2 ( KIAA0634,bA67K19.1 )
Gene Full Name: astrotactin 2
Band: 9q33.1
Quick LinksEntrez ID:23245; OMIM: 612856; Uniprot ID:ASTN2_HUMAN; ENSEMBL ID: ENSG00000148219; HGNC ID: 17021
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
ADHD
PSYCH
PHARMACOGENOMIC
attention-deficit hyperactivity disorder
response to antipsychotic treatment
Desease Name
Response to antipsychotic treatment
Biplolar disorder and schizophrenia
Attention deficit hyperactivity disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ASTN2 mRNA]affects reaction|increases expression 18700144
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ASTN2 proteinaffects expression 20106945
D001241 Aspirin Aspirin results in increased expression of ASTN2 mRNAincreases expression 11906190
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the expression of ASTN2 mRNAaffects expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of ASTN2 mRNAincreases expression 20678512
C004648 testosterone enanthate testosterone enanthate affects the expression of ASTN2 mRNAaffects expression 17440010
D014635 Valproic Acid Valproic Acid results in increased expression of ASTN2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.9320485159 12372130
MESH:D001321 Autistic Disorder marker/mechanism 19404257
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8619460635 15238991 19232924 18985861 18396377 20603192 18316065 18940202 17157402 18775368 17507914 18177632 17688650 16609825 18558336
MESH:D001714 Bipolar Disorder Valproic Acid 3.2017594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001932 Brain Neoplasms Aspirin 4.6815481559
MESH:D001943 Breast Neoplasms Aspirin 2.0315161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0317474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 2.0317123778
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.003084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.0021507988 12907637 12619106
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D003110 Colonic Neoplasms Aspirin 3.0212411196
MESH:D015179 Colorectal Neoplasms Aspirin 2.7517047198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0119739265 12392966 12705907 16227642 17906064 16109766 11287661 11421492 12153990 15968718 10915739 19085960 10663392 18071297 18713872 17562736 19420014 16781746 11743745 11834606 11739529 11461765 11529661 16485898 12594235 17522070 19164858 12958197 15619225 19370779 14550746 10774834 19923254 14986274 2444490 19416960 12540782 16177239 14725611 16081117 16393943
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.0119641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004487 Edema Aspirin 4.1717259670
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.363922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Valproic Acid 3.5819224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.468888407 18558336
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005909 Glioblastoma Aspirin 4.1212870263
MESH:D006261 Headache Aspirin 5.4015240983
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1917440010
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D012001 Hyperacusis Aspirin 6.2115240983
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D007333 Insulin Resistance bisphenol A 3.4616393666
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008107 Liver Diseases Acetaminophen 1.6812969438 16610002 19014921 16611625 12587719 19460945 11587558 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.862125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8620195826 21137059
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.908603461
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4814755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4820064080 17053015 20869020 6695378 18569708 18520028 20464547 20135361 18816296
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008881 Migraine Disorders Aspirin 8.5115240983
MESH:D008881 Migraine Disorders Valproic Acid 8.5118765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D009203 Myocardial Infarction Aspirin 3.6512692751
MESH:D009325 Nausea Aspirin 5.6615240983
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009421 Nervous System Malformations bisphenol A 4.3016427766 11399458
MESH:D009436 Neural Tube Defects Valproic Acid 3.308888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010003 Osteoarthritis Aspirin 4.217009135
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010146 Pain Acetaminophen 7.7216870215
MESH:D010146 Pain Aspirin 7.726995502 6363464
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.9411156591
MESH:D020795 Photophobia Aspirin 6.2115240983
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 11.1010548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 11.1020603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1617292933
MESH:D011471 Prostatic Neoplasms bisphenol A 3.1616740699
MESH:D019310 Pseudolymphoma Valproic Acid 4.9812752131 11422049
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012220 Rhinitis Aspirin 4.6412372130
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.913137016 16876388 11738929 15475178 1511512 17978042 11044598 14763951
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.6212269725
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4810029692 19755658
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Aspirin 4.6016403987
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816684133 16045194
MESH:D013927 Thrombosis Aspirin 4.7617672075
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2617053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014581 Urticaria Acetaminophen 9.9310982225
MESH:D014581 Urticaria Aspirin 9.9320485159 10982225
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25076
    • No data
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    PA447216Schizophrenia
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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