AutismKB 2.0

Annotation Detail for ANKRD12


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Basic Information Top
Gene Symbol:ANKRD12 ( ANCO-2,ANCO1,FLJ20053,GAC-1,KIAA0874,Nbla00144 )
Gene Full Name: ankyrin repeat domain 12
Band: 18p11.22
Quick LinksEntrez ID:23253; OMIM: 610616; Uniprot ID:ANR12_HUMAN; ENSEMBL ID: ENSG00000101745; HGNC ID: 29135
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of ANKRD12 mRNAincreases expression 15761015
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of ANKRD12 mRNAincreases expression 18687144
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ANKRD12 mRNAdecreases expression 17484886
D003010 Clorgyline Clorgyline results in increased expression of ANKRD12 mRNAincreases expression 19691856
D016572 Cyclosporine Cyclosporine results in increased expression of ANKRD12 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of ANKRD12 mRNAdecreases expression 20068009
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ANKRD12 mRNAincreases expression 20106945
D014810 Vitamin E Vitamin E results in decreased expression of ANKRD12 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 11752688 15322242
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5619825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 4.5611473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.7816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Estradiol 1.9112948864 16675129 17289903 17261762 17018787 14630087 19861407 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.9810355542 18705752 15721981 16124888 15673190 16011737 15700767 16097048 16050911 16227642 3786805 16192424
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.9816050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7716217749 15553829 14691202 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7718788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7716924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1112371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1118566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 8697196 12621046 16354765 15668235
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8919769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9215998439 10915739 6623471 7440962 17522070 21278145 9327722 16227642 4309450 16177239 15968718 19085960 3732212 15027814 3786805 19336974 7120509 10092053 11566570 7179309 2869522 6884620
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.1311473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver arsenic trioxide 14.5815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.5816045604 17595544 12631006 16239168 19224547 15959796 61145 12795759
MESH:D005234 Fatty Liver Cyclosporine 14.5819224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 16.5818705752
MESH:D005355 Fibrosis Cyclosporine 16.5812639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.5820067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9511294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9516080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 11.3417088409
MESH:D019584 Hot Flashes Vitamin E 11.3414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 18606429 16959395 15340226 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.5916624496
MESH:D007333 Insulin Resistance Estradiol 3.1116393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 10.808314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.8015618244
MESH:D007674 Kidney Diseases Vitamin E 10.8012488133
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.9515610895
MESH:D007938 Leukemia arsenic trioxide 2.9315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0417077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1720471514 19850784 16467208 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3619642359 12679006 19035177 16331271 17649720 12018890 17107899 16330433 16112521 15748426 16823087 12712474 11468182 9834237 16966277 17217047 16891316 17712046 15622746 15336539 15213294 19075265 11161223 17869043 19225113
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9216221502 11408273 17334410 16943688 17174718 11903743 16239168 21278145 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1417766677 18705752 17761835 18277467 12632512 11481614 12667390 17823541 16248980 18481824 17631135 18472094 15338365 16015684 16192424 15057751 17708605 16638106 18251166 18054572 18412020 12632514 17805973 14512876 18395914 18317297 12958196 15673190 18376398 20821823 13678700 16116963 15818738 12445418 17714472 14716496 18187930 12649538 18418968 17481882 16033810 12389079 15123356 15925388 17976157 17565644 16011737 12898905 15876570 17557913 18420326 15650968 18339082 14620537 12445421 17922224 17640975 18210741 18395095 15931870 12609069 15730626 12741479 15893842 18263696 18006644 14716833 17869086 15362042 17698563 16027843 18472332 15959796 17944888 18166357 14748882 15996030 15370692 18156304 12546737 18279442 12666154 18429990 14724832 17721639 16136751 15052691 10355542 18205269 16097048 12586293 17900296 17525996
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.1414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1412878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.1416169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1316246199 17285989 15720792 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9216899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8714682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.8719294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.6420377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.6415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3317365036
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5319825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5311884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.5311062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7011807958 11408345 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2618303189 16166281 16966607
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2715949261 19417148 11468182 14977855 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616105982 16882451
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4616810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 10.4216427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4214600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2610525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0416624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 5.0419401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5915580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2010923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0919131511
MESH:D011471 Prostatic Neoplasms Clorgyline 2.0919691856
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0915084515
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1015814490 17365031 17975199 17322281
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2719014326
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5620435036 11780464 12845720 12973940
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134899860
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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