AutismKB 2.0

Annotation Detail for KAZ


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Basic Information Top
Gene Symbol:KAZ ( DKFZp686D08115,FLJ10199,FLJ32593,FLJ43398,FLJ43806,KIAA1026,MGC126686,MGC142181 )
Gene Full Name: -
Band: 1p36.21
Quick LinksEntrez ID:23254; OMIM: NA; Uniprot ID:KAZRN_HUMAN; ENSEMBL ID: ENSG00000189337; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004317 Doxorubicin KAZN protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D016685 Mitomycin KAZN protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of KAZN mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of KAZN mRNAaffects cotreatment|decreases expression 19059307
D014501 Uranium Uranium affects the expression of KAZN mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of KAZN mRNAaffects expression 15672453
D014747 Vinblastine KAZN protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000230 Adenocarcinoma Doxorubicin 2.6217418594
MESH:D000419 Albuminuria Doxorubicin 12.5821441931
MESH:D000419 Albuminuria Raloxifene 12.5817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.1414601052
MESH:D001930 Brain Injuries Raloxifene 4.8316580743
MESH:D001932 Brain Neoplasms Doxorubicin 4.0717150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.0018628466 16595493 16096432 16115903 18695136 15634643 19526202 16322301 16264153 15994142 15136595 17426702 15939500 15567936 15668708 18382427 16826403 17983394 16935488 17369602 15692762 11325840 15993339 18234424
MESH:D001943 Breast Neoplasms Raloxifene 2.0015758505 17242785 17893378 17261762 15572757 15775269 17595753 17049068 17952589 17440819 16837676 16912660
MESH:D001943 Breast Neoplasms Tamoxifen 2.0019059307 20135344 18425577 19189210 17440819 19084267 20859285 16202921 19288272 15565566 19289846 17893378 19410462 15668708 16873071 19142967 19103187 18351453 16273361 18629630 19487384 19189212 21138602 17242785 19200415 19115204 17261762 19221464 21152245 18855134 19244106 19011961 20390343 18815881 17049068 19155303 18997820 11161223 20005174 20544844 18984771 18821012 16818667 20065188 19066611
MESH:D002276 Carcinoid Tumor Doxorubicin 5.2516051944
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.2616023760 18059187 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.2616924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.331485588 16201981
MESH:D002292 Carcinoma, Renal Cell Vinblastine 7.331485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.706189445
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.4017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.4017572228
MESH:D009202 Cardiomyopathies Doxorubicin 3.7017382496 16109756 15792986 16269455 15811867 17308081 16952015 15505089 16278810 16364871 17974986 17329180 16612575 18627295 17928571 17351982 17007740 15476868 17924179 16651473 16242529 17131338 16455267 16731534 17519947
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0217334414 16243910
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6315775269
MESH:D003072 Cognition Disorders Raloxifene 4.9815800139
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9818802399 18259882
MESH:D015179 Colorectal Neoplasms Vinblastine 2.9818802399
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4117474826
MESH:D003928 Diabetic Nephropathies Raloxifene 9.8717451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.8719279558
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5017416283
MESH:D004362 Drug Toxicity Doxorubicin 3.8718602426
MESH:D004487 Edema Raloxifene 3.6115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.3615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.3619031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 8.1317359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.1316202921 19155303 20544844 17893378
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6018037988
MESH:D005234 Fatty Liver Raloxifene 8.9417473493
MESH:D005234 Fatty Liver Tamoxifen 8.9414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 12.8019069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 12.8019069698
MESH:D005909 Glioblastoma Doxorubicin 3.5217150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7015692506
MESH:D006331 Heart Diseases Doxorubicin 8.4618674790 16330681 17875725 16707910 16495754 16144979 16244372 17888722 16879835 12587719 18006777 16244371 14766674
MESH:D006331 Heart Diseases Raloxifene 8.4611110106
MESH:D006333 Heart Failure Doxorubicin 3.5017481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1815692506
MESH:D006689 Hodgkin Disease Doxorubicin 8.6315147373 18501091 17606976
MESH:D006689 Hodgkin Disease Vinblastine 8.6318501091 18180244
MESH:D006973 Hypertension Raloxifene 2.9517577099 15787275
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007674 Kidney Diseases Doxorubicin 3.2015699352 15369732 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4416707910
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2718625569
MESH:D007889 Leiomyoma Raloxifene 4.8016973256
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6016085563
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.6816439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.6818564211
MESH:D008113 Liver Neoplasms Mitomycin 5.2615113037
MESH:D008113 Liver Neoplasms Tamoxifen 5.2616684651
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1716842330 17085340
MESH:D008175 Lung Neoplasms Doxorubicin 2.6517418594 6189445
MESH:D008175 Lung Neoplasms Tamoxifen 2.6518625569
MESH:D008223 Lymphoma Doxorubicin 3.6516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9315621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.7015458769
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.7019196722 11731420 19196723 14580682 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Doxorubicin 5.4916827129
MESH:D008545 Melanoma Tamoxifen 5.4912393984 19393235
MESH:D008545 Melanoma Vinblastine 5.4918332650 15577320 15577323 18176117 16432458 12374674 16248763 17761969 16809738 18505091
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008654 Mesothelioma Doxorubicin 3.1517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7815792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0015863610
MESH:D052016 Mucositis Doxorubicin 5.1917415656
MESH:D009101 Multiple Myeloma Raloxifene 3.6316497877
MESH:D009203 Myocardial Infarction Doxorubicin 3.0415857846 19429709
MESH:D009232 Myxoma Raloxifene 6.0016343187
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.1818259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.1819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19196722 19200415
MESH:D009401 Nephrosis Doxorubicin 5.1316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2515640375 16889571
MESH:D009447 Neuroblastoma Doxorubicin 3.3915555623
MESH:D009503 Neutropenia Vinblastine 4.8717378895
MESH:D010024 Osteoporosis Raloxifene 3.5515775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5317823083 17893378 15579764 15758505
MESH:D012516 Osteosarcoma Doxorubicin 4.3415930896
MESH:D010190 Pancreatic Neoplasms Mitomycin 3.5315113037
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6017638057
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.6015897917 15749863 18437689 16868541 16729912 16888761
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6015731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6015067354
MESH:D011693 Purpura Raloxifene 6.0015770314
MESH:D051437 Renal Insufficiency Doxorubicin 4.5817922066
MESH:D012509 Sarcoma Doxorubicin 4.2517203757 16767912 18313854 15625365 15675481 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1917846226
MESH:D012878 Skin Neoplasms Doxorubicin 3.0615692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9317203757 15625365 16767912
MESH:D013088 Spermatocele Tamoxifen 4.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D020521 Stroke Raloxifene 4.0416837676
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5817909728 16010429
MESH:D013978 Tibial Fractures Raloxifene 5.6519048282
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.9717653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.9717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.9716712894 8653321 17572228
MESH:D014625 Vaginal Neoplasms Vinblastine 5.4015577323
MESH:D054556 Venous Thromboembolism Raloxifene 5.6516837676
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5817678736 17638931 17334414 16364871
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0016343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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