AutismKB 2.0

Annotation Detail for SCFD1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SCFD1 ( C14orf163,KIAA0917,RA410,SLY1,STXBP1L2 )
Gene Full Name: sec1 family domain containing 1
Band: 14q12
Quick LinksEntrez ID:23256; OMIM: NA; Uniprot ID:SCFD1_HUMAN; ENSEMBL ID: ENSG00000092108; HGNC ID: 20726
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen results in decreased expression of SCFD1 mRNAdecreases expression 11793227
D000082 Acetaminophen Acetaminophen affects the expression of SCFD1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SCFD1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SCFD1 mRNAincreases expression 20127859
D002110 Caffeine Caffeine results in decreased expression of SCFD1 mRNAdecreases expression 11793227
D016572 Cyclosporine Cyclosporine results in increased expression of SCFD1 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of SCFD1 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of SCFD1 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SCFD1 mRNAaffects binding|decreases expression|increases activity 19710929
D013853 Thioacetamide Thioacetamide results in decreased expression of SCFD1 mRNAdecreases expression 11793227
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.8819483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 9.8819483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0917474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 2.0920435547
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.153084413
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 3.1517997003
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.4718291259
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1410774834 10915739 12392966 19164858 17522070 11743745 15968718 17562736 16781746 19416960 12705907 16393943 16227642 19370779 15619225 11739529 16177239 12594235 16081117 12153990 19085960 11461765 16109766 18713872 14725611 12540782 12958197 19739265 14986274 14550746 11834606 11287661 11421492 19420014 18071297 2444490 10663392 19923254 17906064 16485898 11529661
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 4.1412963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005218 Fat Necrosis Thioacetamide 6.0416456712
MESH:D005234 Fatty Liver Cyclosporine 14.2919224547
MESH:D005234 Fatty Liver Dietary Fats 14.2918296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver pirinixic acid 14.2920131406 19236843
MESH:D005355 Fibrosis Cyclosporine 9.5712639820 12168785
MESH:D005355 Fibrosis Dietary Fats 9.5718296743
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.7818665440 15929193 17276928
MESH:D006505 Hepatitis Caffeine 10.8011394713
MESH:D006505 Hepatitis Thioacetamide 10.8016456712
MESH:D006529 Hepatomegaly pirinixic acid 3.2518467677 19176532 19772884 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007249 Inflammation Dietary Fats 2.5220412841
MESH:D007333 Insulin Resistance Dietary Fats 7.6711836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.168314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9818296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.6015474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.6015158331 18263696 15362042 15078482 18031379 18416461 12557150 12679928 15716488 12085344 15288472 14739098 17629604 18395095 12891558 16511523 11172339 11481614 17355460 16098781 16248980 16126171 16343077 18606216 18380797 16097051 18032466 10677585 18458672 18615449 18295389 17127702 12175628 15288473 15465738 12531686 15474484 15075984 11682029 15334695 17292413 17050028 15095483 16489207 15316131
MESH:D008107 Liver Diseases Acetaminophen 4.2812969438 11587558 19460945 19784758 19014921 12587719 16610002 16611625
MESH:D008107 Liver Diseases Thioacetamide 4.2816337175 18374380 15158337
MESH:D017114 Liver Failure, Acute Acetaminophen 10.2917185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 10.2915633222 15313186 17276928 12479984
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5921137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.5916377806 15890375 20007298
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618816296 20464547 20135361 18569708 18520028 6695378 20064080 17053015 20869020
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity Dietary Fats 4.5818674790 20518802 21332399 11836018 18457598 17217161 19632207 20132043 16723640
MESH:D009765 Obesity pirinixic acid 4.5820558911
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4510029692 19755658
MESH:D012893 Sleep Disorders Caffeine 5.6019395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 5.4217225163
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved