AutismKB 2.0

Annotation Detail for DENND5A


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Basic Information Top
Gene Symbol:DENND5A ( FLJ22354,FLJ33829,FLJ43455,KIAA1091,RAB6IP1 )
Gene Full Name: DENN/MADD domain containing 5A
Band: 11p15.4
Quick LinksEntrez ID:23258; OMIM: NA; Uniprot ID:DEN5A_HUMAN; ENSEMBL ID: ENSG00000184014; HGNC ID: 19344
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026114 2-xylene 2-xylene results in increased expression of DENND5A mRNAincreases expression 20359517
D000082 Acetaminophen Acetaminophen affects the expression of DENND5A mRNAaffects expression 17562736
C430898 AGN 194204 AGN 194204 results in decreased expression of DENND5A mRNAdecreases expression 16339527
D001241 Aspirin Aspirin results in increased expression of DENND5A mRNAincreases expression 11906190
D001554 Benzene Benzene results in increased expression of DENND5A mRNAincreases expression 20359517
D016572 Cyclosporine Cyclosporine results in increased expression of DENND5A mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of DENND5A mRNAincreases expression 20106945
C004912 ethylbenzene ethylbenzene results in increased expression of DENND5A mRNAincreases expression 20359517
D007657 Ketone Bodies Ketone Bodies results in increased expression of DENND5A mRNAincreases expression 16807920
D008752 Methylene Chloride Methylene Chloride results in increased expression of DENND5A mRNAincreases expression 20359517
D014050 Toluene Toluene results in increased expression of DENND5A mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of DENND5A mRNAincreases expression 20359517
D014810 Vitamin E Vitamin E results in increased expression of DENND5A mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D000741 Anemia, Aplastic Benzene 4.4311369114 14761424 17661222
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.7612372130 20485159
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001836 Body Weight Changes 2-xylene 6.057457028
MESH:D001855 Bone Marrow Diseases Benzene 5.3616183116
MESH:D001932 Brain Neoplasms Aspirin 4.4915481559
MESH:D001943 Breast Neoplasms Aspirin 2.4315161893
MESH:D001943 Breast Neoplasms Benzene 2.4317162533 11921183
MESH:D001943 Breast Neoplasms Estradiol 2.4316675129 19861407 17018787 17261762 14630087 17289903 18497071 12948864
MESH:D001943 Breast Neoplasms Methylene Chloride 2.4315986119
MESH:D001943 Breast Neoplasms Trichloroethylene 2.4315986119
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.853084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.8516924424
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7618566989
MESH:D002547 Cerebral Palsy Toluene 5.979294310
MESH:D002779 Cholestasis Cyclosporine 2.9719486331
MESH:D003110 Colonic Neoplasms Aspirin 2.9912411196
MESH:D015179 Colorectal Neoplasms Aspirin 2.7517047198
MESH:D019465 Craniofacial Abnormalities Benzene 4.1115643154
MESH:D019465 Craniofacial Abnormalities Toluene 4.119294310
MESH:D019465 Craniofacial Abnormalities Vitamin E 4.1119769572
MESH:D003643 Death Toluene 5.806431079
MESH:D003872 Dermatitis Benzene 4.8715902427
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.2616781746 16109766 16485898 17906064 11739529 17522070 10774834 16081117 16393943 11421492 14550746 11287661 12153990 18071297 10663392 19739265 17562736 10915739 12705907 15968718 19370779 19416960 12540782 11461765 12392966 19085960 14725611 11834606 2444490 16177239 11743745 14986274 11529661 15619225 18713872 12958197 19923254 19420014 19164858 12594235 16227642
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 4.267120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema Aspirin 3.9717259670
MESH:D016889 Endometrial Neoplasms Estradiol 3.0319148513 11473722 18566989
MESH:D005234 Fatty Liver Cyclosporine 2.9419224547
MESH:D005355 Fibrosis Cyclosporine 3.2412639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Aspirin 4.0012870263
MESH:D006261 Headache Aspirin 5.0915240983
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0316080930
MESH:D006402 Hematologic Diseases Benzene 4.7416183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006529 Hepatomegaly 2-xylene 5.127457013 7457028
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 10.5017088409
MESH:D019584 Hot Flashes Vitamin E 10.5014716179
MESH:D012001 Hyperacusis Aspirin 5.9015240983
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006973 Hypertension Benzene 5.4817940673
MESH:D006973 Hypertension Cyclosporine 5.4810903974
MESH:D007251 Influenza, Human Vitamin E 4.3516624496
MESH:D007333 Insulin Resistance Estradiol 3.0216393666 16627594
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 14.7912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.798314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 14.7915618244
MESH:D007674 Kidney Diseases Vitamin E 14.7912488133
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5012371664
MESH:D007680 Kidney Neoplasms Estradiol 7.5015610895
MESH:D007938 Leukemia Benzene 3.4317119257 14694614 18335105 15935818
MESH:D007951 Leukemia, Myeloid Benzene 4.4017506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7119478238
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5216169303
MESH:D008107 Liver Diseases Acetaminophen 1.6519784758 12969438 12587719 16611625 11587558 19460945 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008114 Liver Neoplasms, Experimental Benzene 6.8012562636
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 6.807955063
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.9414698565
MESH:D008175 Lung Neoplasms Benzene 3.8112562636
MESH:D008175 Lung Neoplasms Methylene Chloride 3.8115172992
MESH:D008175 Lung Neoplasms Vitamin E 3.8111062179
MESH:D008223 Lymphoma Benzene 3.7917119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.5612562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.3911921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3917203775 11408345 11807958 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008607 Mental Retardation Toluene 3.679294310
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D008881 Migraine Disorders Aspirin 4.1215240983
MESH:D019957 Motor Skills Disorders Toluene 5.329294310
MESH:D009101 Multiple Myeloma Benzene 3.7217119195
MESH:D009203 Myocardial Infarction Aspirin 3.5812692751
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009325 Nausea Aspirin 5.3515240983
MESH:D009369 Neoplasms Trichloroethylene 3.5911911487
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 3.7516427766 11399458
MESH:D009436 Neural Tube Defects Benzene 3.7215643154
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009784 Occupational Diseases Benzene 4.2617479406 15913788 17119257 16737584 17178637 15612468 15576619 15935809 15727169
MESH:D010003 Osteoarthritis Aspirin 4.107009135
MESH:D010051 Ovarian Neoplasms Benzene 5.1112562636
MESH:D010051 Ovarian Neoplasms Estradiol 5.1119401270
MESH:D010146 Pain Acetaminophen 7.1616870215
MESH:D010146 Pain Aspirin 7.166995502 6363464
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.6611156591
MESH:D020795 Photophobia Aspirin 5.9015240983
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms AGN 194204 2.6916000583
MESH:D011471 Prostatic Neoplasms Estradiol 2.6916740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6915084515
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D012220 Rhinitis Aspirin 4.4512372130
MESH:D012640 Seizures Toluene 3.776431079 9294310
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.3712269725
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D020521 Stroke Aspirin 9.1316403987
MESH:D020521 Stroke Vitamin E 9.1316517955
MESH:D013733 Testicular Diseases Toluene 5.0710514026 10048760
MESH:D013927 Thrombosis Aspirin 4.5917672075
MESH:D013953 Thymus Neoplasms Benzene 5.0710850423
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014581 Urticaria Acetaminophen 9.2010982225
MESH:D014581 Urticaria Aspirin 9.2020485159 10982225
MESH:D014594 Uterine Neoplasms Benzene 4.4312562636
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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