AutismKB 2.0

Annotation Detail for LPHN2


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Basic Information Top
Gene Symbol:LPHN2 ( CIRL2,CL2,LEC1,LPHH1 )
Gene Full Name: latrophilin 2
Band: 1p31.1
Quick LinksEntrez ID:23266; OMIM: 607018; Uniprot ID:LPHN2_HUMAN; ENSEMBL ID: ENSG00000117114; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in decreased expression of LPHN2 mRNAdecreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LPHN2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of LPHN2 mRNAaffects expression 17562736
C006780 bisphenol A bisphenol A results in increased expression of LPHN2 mRNAincreases expression 12075121
D016572 Cyclosporine Cyclosporine results in decreased expression of LPHN2 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of LPHN2 mRNAincreases expression 18042831
D000431 Ethanol Ethanol results in increased expression of LPHN2 mRNAincreases expression 15353170
D005472 Fluorouracil LPHN2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D008727 Methotrexate LPHN2 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D009151 Mustard Gas Mustard Gas affects the expression of LPHN2 mRNAaffects expression 15651846
C041786 palm oil palm oil results in increased expression of LPHN2 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LPHN2 mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LPHN2 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 15.0717676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 15.0712039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 15.0714514962 15322242 11752688
MESH:D000138 Acidosis Ethanol 4.6111192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.4417638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4515451039 15451040
MESH:D000740 Anemia Fluorouracil 8.9417963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9411748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D000853 Anophthalmos Ethanol 4.9215513904
MESH:D001008 Anxiety Disorders Ethanol 4.0711141031
MESH:D001161 Arteriosclerosis Dietary Fats 3.9915238619
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1117286800
MESH:D001249 Asthma Mustard Gas 2.7310378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001862 Bone Resorption bisphenol A 3.9411985600
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 3.0011921183
MESH:D001943 Breast Neoplasms bisphenol A 3.0017123778
MESH:D001943 Breast Neoplasms Dietary Fats 3.0020435547
MESH:D001943 Breast Neoplasms Fluorouracil 3.0016110121 15136595 18608205 19217205 16595493 18357371 16557594
MESH:D001943 Breast Neoplasms Methotrexate 3.0016978400
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0020435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1117687719 10378619
MESH:D002056 Burns Ethanol 4.7616374292
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 8.4017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4016835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.693084413
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.6915763234 15289165 18788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.6917045692 17971768 16332177 17088986 16799960 18930000
MESH:D002278 Carcinoma in Situ bisphenol A 5.1117123778
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0518695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5116757204 18986760 17066447 16280240
MESH:D006332 Cardiomegaly Ethanol 6.9919332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9918850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5812371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 7.9619486331
MESH:D002779 Cholestasis pirinixic acid 7.9619176532
MESH:D002971 Cleft Lip Ethanol 3.6215513904
MESH:D002972 Cleft Palate Ethanol 6.0615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0615668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2416510598 17287894 15001691 17725105 17016597 18772588 17169374 16340194 17172411 17018589
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017094418 18383874 20501625 17454858 18448328 16282729 16391804 17695437 17594712 17401013 17016601 16303861 18949393 15148649 18288408 16524972 17255274 18802399 14970324 15289873 18509181 16331619
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 3.9815513904 15451039 11873399 19302082 10194807 11198716 15451040
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.989562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9820055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.3119747007
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003882 Dermatomyositis Methotrexate 5.2220191521
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.1621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1618713872 11461765 19420014 18071297 14550746 19416960 11529661 17522070 11743745 14725611 10663392 10915739 12392966 11421492 19370779 16781746 16485898 15968718 16393943 12958197 12594235 12705907 12540782 11287661 17562736 17906064 19085960 19739265 12153990 16227642 11739529 14986274 16081117 11834606 2444490 16109766 19923254 10774834 16177239 19164858 15619225
MESH:D056486 Drug-Induced Liver Injury Ethanol 9.1611566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004487 Edema Mustard Gas 11.9111428647 9260866 11402378 11428631
MESH:D004487 Edema pirinixic acid 11.9112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.9112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D004938 Esophageal Neoplasms Ethanol 4.8316704527
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.8315173087 17638652 16481741 16337965 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 19.4819224547
MESH:D005234 Fatty Liver Dietary Fats 19.4817967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Ethanol 19.4819236843 16409862 18620774
MESH:D005234 Fatty Liver pirinixic acid 19.4819236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8017920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4216946407 10194807 15513904 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Cyclosporine 15.3512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 15.3518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.3520067830
MESH:D005756 Gastritis Acetaminophen 11.5816983495
MESH:D005756 Gastritis Ethanol 11.5815046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.2516518429
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4415102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6116221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 16959395 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 8.0316870215
MESH:D006930 Hyperalgesia Ethanol 8.0318783367
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D007249 Inflammation Dietary Fats 8.5720412841
MESH:D007249 Inflammation Mustard Gas 8.578975870 11402378 11428620 9357497 9260866 16001271 17524151 11428647 11428631
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5712878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 12.6416393666
MESH:D007333 Insulin Resistance Dietary Fats 12.6411836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 12.6416306350
MESH:D007569 Jaw Abnormalities Ethanol 10.3915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.948314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.8216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.8212371664
MESH:D007680 Kidney Neoplasms Fluorouracil 12.8216985049
MESH:D007805 Language Development Disorders Methotrexate 5.199562676
MESH:D007859 Learning Disorders Ethanol 4.3115451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8717676605
MESH:D008103 Liver Cirrhosis Dietary Fats 11.4618296743
MESH:D008103 Liver Cirrhosis Ethanol 11.4615289165
MESH:D008103 Liver Cirrhosis Methotrexate 11.4614986274
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2118295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.5118166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008107 Liver Diseases Acetaminophen 1.6519460945 11587558 19014921 12587719 19784758 16611625 12969438 16610002
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7617207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms Fluorouracil 7.5416603448 15113037 18383874 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 7.5416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1512151625
MESH:D008171 Lung Diseases Mustard Gas 3.5018161513 18702808
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.1618516814
MESH:D008175 Lung Neoplasms Fluorouracil 3.5115246190
MESH:D008175 Lung Neoplasms Mustard Gas 3.513148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5119555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008223 Lymphoma Methotrexate 4.0117352296
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.6311921183
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008569 Memory Disorders Ethanol 4.2818411066 15451040
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6918986760 16757204
MESH:D052016 Mucositis Methotrexate 5.4017488658
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009369 Neoplasms Fluorouracil 5.1118600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 5.1117405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 9.9016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.9014600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D009503 Neutropenia Mustard Gas 4.067688884 16761898
MESH:D009765 Obesity Dietary Fats 4.4921332399 11836018 17217161 20132043 18674790 20518802 18457598 16723640 19632207
MESH:D009765 Obesity pirinixic acid 4.4920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5012819281 16049721
MESH:D010049 Ovarian Diseases bisphenol A 5.1111985600
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Ethanol 5.6112384795
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6115113037 16929163 19003803 16500647
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.9010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.9011118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3716740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3718626508 19082440
MESH:D011537 Pruritus Mustard Gas 4.2118058305
MESH:D011565 Psoriasis Cyclosporine 5.9916882103
MESH:D011565 Psoriasis Methotrexate 5.9917410198
MESH:D011629 Puberty, Precocious bisphenol A 4.9010548101
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9517720292 10334151 17620002 17266442 17894541
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0816160472 15538739 18722050 18286688
MESH:D051437 Renal Insufficiency Methotrexate 4.8217352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2818551238
MESH:D012640 Seizures Ethanol 6.289754883
MESH:D012871 Skin Diseases Mustard Gas 2.7315451306 12880345 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013274 Stomach Neoplasms Ethanol 2.7118456281
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7118396642 18567086 17522103 15786421 16424979 17172411 19015929 19084572 16951190 17498489
MESH:D013276 Stomach Ulcer Ethanol 3.619562338 11906479 9211565 17918041 17189318 16755016
MESH:D019966 Substance-Related Disorders bisphenol A 4.1016045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.339754883
MESH:D013576 Syndactyly Methotrexate 5.139562676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0616280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9516803524
MESH:D014591 Uterine Diseases bisphenol A 5.1414652134
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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