AutismKB 2.0

Annotation Detail for DNMBP


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Basic Information Top
Gene Symbol:DNMBP ( ARHGEF36,KIAA1010,TUBA )
Gene Full Name: dynamin binding protein
Band: 10q24.2
Quick LinksEntrez ID:23268; OMIM: 611282; Uniprot ID:DNMBP_HUMAN; ENSEMBL ID: ENSG00000107554; HGNC ID: 30373
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200059Regulation of CDC42 activity
No data
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Related Diseases/Disorders Top
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Desease Name
Alzheimer's disease
NEUROLOGICAL
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DNMBP mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of DNMBP mRNAincreases expression 18687144
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of DNMBP mRNAincreases expression 15336504
D004958 Estradiol Estradiol affects the expression of DNMBP mRNAaffects expression 14699072
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DNMBP mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of DNMBP mRNAincreases expression 19619570
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DNMBP mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of DNMBP mRNAincreases expression 18445702
18301758
D020849 Raloxifene Raloxifene affects the expression of DNMBP mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of DNMBP mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DNMBP mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DNMBP mRNAincreases expression 19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000419 Albuminuria Raloxifene 4.8817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001930 Brain Injuries Raloxifene 4.7816580743
MESH:D001943 Breast Neoplasms Estradiol 1.9712948864 14630087 17289903 17018787 16675129 17261762 19861407 18497071
MESH:D001943 Breast Neoplasms Raloxifene 1.9717440819 17242785 16912660 17261762 15758505 17595753 15572757 17952589 17893378 16837676 15775269 17049068
MESH:D001943 Breast Neoplasms Tamoxifen 1.9718984771 19011961 18629630 16202921 20005174 20544844 19288272 20135344 19289846 18855134 19155303 19115204 19059307 19221464 20859285 18351453 19103187 19189210 20065188 11161223 16818667 17893378 17242785 18815881 21152245 19189212 19066611 19142967 19244106 15565566 18425577 16873071 17049068 19410462 17261762 21138602 19200415 15668708 18821012 17440819 16273361 19487384 20390343 19084267 18997820
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.693084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6916924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6916924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.2717572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.2717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6015775269
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9318566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 12621046 8697196 15668235 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.9215800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3817474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 16.3119279558
MESH:D003928 Diabetic Nephropathies Raloxifene 16.3115920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 16.3119279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7519416960 12958197 11743745 16177239 11461765 15968718 11739529 19085960 14725611 11421492 19739265 17906064 16781746 16109766 10774834 12705907 11529661 11287661 19370779 18071297 11834606 10915739 12392966 17522070 16485898 16081117 16393943 12153990 15619225 18713872 19923254 19420014 14986274 17562736 12594235 2444490 19164858 16227642 10663392 14550746 12540782
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema pirinixic acid 12.8812083418
MESH:D004487 Edema Raloxifene 12.8815860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.8812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.2015845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2019031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.8919148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.8919155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver pirinixic acid 14.6120131406 19236843
MESH:D005234 Fatty Liver Raloxifene 14.6117473493
MESH:D005234 Fatty Liver Tamoxifen 14.6114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.6911110106
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly pirinixic acid 9.3016221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Raloxifene 5.4915787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4918670907 18850075
MESH:D007249 Inflammation Tamoxifen 5.2619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2612200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.6916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.6916306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 6.3115629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.3115618244
MESH:D007680 Kidney Neoplasms Estradiol 8.0715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.0718625569
MESH:D007889 Leiomyoma Raloxifene 4.7616973256
MESH:D008064 Lipidoses Tamoxifen 3.3217567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.1114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.1118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1112878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719784758 12969438 19460945 16610002 12587719 16611625 11587558 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 7.7915890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 7.7916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3317365036
MESH:D008175 Lung Neoplasms Tamoxifen 2.3018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3019555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4616891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.4619196723 11731420 19196722 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 13.9419453300
MESH:D020149 Manganese Poisoning Tamoxifen 13.9419453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2618303189 16166281 16966607
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.9315863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6016497877
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.8716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.8716411023
MESH:D009232 Myxoma Raloxifene 5.9316343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009421 Nervous System Malformations Estradiol 10.4216427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4214600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010024 Osteoporosis Raloxifene 3.5317882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4917893378 15579764 17823083 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 2.2819401270
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2010923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5516740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5516536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5515067354
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1017322281 17365031 17975199 15814490
MESH:D011693 Purpura Raloxifene 5.9315770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.928532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9216192470
MESH:D013088 Spermatocele Tamoxifen 4.6716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D020521 Stroke Raloxifene 4.0116837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013978 Tibial Fractures Estradiol 15.0019048282
MESH:D013978 Tibial Fractures Raloxifene 15.0019048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5016712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.5816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.9316343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134950706
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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