AutismKB 2.0

Annotation Detail for MGA


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Basic Information Top
Gene Symbol:MGA ( FLJ12634,KIAA0518,MAD5,MXD5 )
Gene Full Name: MAX gene associated
Band: 15q15
Quick LinksEntrez ID:23269; OMIM: NA; Uniprot ID:MGAP_HUMAN; ENSEMBL ID: ENSG00000174197; HGNC ID: 14010
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MGA mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MGA mRNAdecreases expression 19150397
20018196
C006780 bisphenol A bisphenol A results in decreased expression of MGA mRNAdecreases expression 20678512
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MGA mRNAaffects binding|increases activity|increases expression 19710929
D014212 Tretinoin Tretinoin affects the expression of MGA mRNAaffects expression 16054129
C025643 vinclozolin vinclozolin affects the expression of MGA mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.0819483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.0816206674 16197459
MESH:D001862 Bone Resorption bisphenol A 4.1911985600
MESH:D001943 Breast Neoplasms bisphenol A 2.2317123778
MESH:D001943 Breast Neoplasms Tretinoin 2.2316873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.983084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.981917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.4517123778
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3616096774 16051514
MESH:D002386 Cataract Acetaminophen 7.7810977129
MESH:D002386 Cataract Tretinoin 7.7817460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8316925845 14991402 17551590 9125849 10589399 8800419 9211117 9664655 9224671 9142499
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6515968718 16781746 19164858 11834606 12392966 18071297 2444490 11287661 17562736 16109766 12540782 10915739 12153990 19085960 18713872 14725611 11421492 12705907 11743745 19739265 11739529 11461765 17522070 19416960 19923254 16081117 15619225 16177239 14550746 16227642 19370779 12958197 10663392 14986274 12594235 17906064 19420014 16393943 16485898 10774834 11529661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005124 Eye Abnormalities Tretinoin 3.819664655 16938888
MESH:D005234 Fatty Liver pirinixic acid 3.0919236843 20131406
MESH:D005355 Fibrosis Tretinoin 3.9317994277
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.049664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4116221962 19772884 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 8.4816870215
MESH:D006930 Hyperalgesia Tretinoin 8.4816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007248 Infertility, Male vinclozolin 3.2416467254
MESH:D007333 Insulin Resistance bisphenol A 7.9616393666
MESH:D007333 Insulin Resistance pirinixic acid 7.9616306350
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2317551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3417361223 17301526 16823087 17368321 16788101 16331271 19075265 19225113 9834237 17712046 16891316 19029980 17649720 16935935 17294898 12679006 17339181 17506722 19035177 16766008 17107899 15748426 19642359 17217047 16140955
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4218397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6919460945 16610002 12969438 11587558 19014921 16611625 12587719 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9120007298 15890375 16377806
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms pirinixic acid 5.3617405874
MESH:D009369 Neoplasms Tretinoin 5.3616594593 16946489
MESH:D009421 Nervous System Malformations bisphenol A 11.0916427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 11.099125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010049 Ovarian Diseases bisphenol A 5.4511985600
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Acetaminophen 7.4916870215
MESH:D010146 Pain Tretinoin 7.4916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5515976015
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 11.3610548101
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 11.3618220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.5320887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3616740699
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D011629 Puberty, Precocious bisphenol A 5.2510548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7316467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019966 Substance-Related Disorders bisphenol A 4.4516045194 16684133
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014591 Uterine Diseases bisphenol A 5.5314652134
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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