AutismKB 2.0

Annotation Detail for TSPYL4


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Basic Information Top
Gene Symbol:TSPYL4 ( KIAA0721,dJ486I3.2 )
Gene Full Name: TSPY-like 4
Band: 6q22.1
Quick LinksEntrez ID:23270; OMIM: NA; Uniprot ID:TSYL4_HUMAN; ENSEMBL ID: ENSG00000187189; HGNC ID: 21559
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TSPYL4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TSPYL4 mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in decreased expression of TSPYL4 mRNAdecreases expression 20106945
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TSPYL4 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of TSPYL4 mRNAdecreases expression 19270015
19482888
D014212 Tretinoin Tretinoin results in increased expression of TSPYL4 mRNAincreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.986195326
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.5117620307
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2316166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.923084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.9217173139 1701930 20007298 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.921917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716051514 16096774
MESH:D002386 Cataract Acetaminophen 7.8510977129
MESH:D002386 Cataract Tretinoin 7.8517460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8314991402 9142499 9664655 10589399 9125849 17551590 8800419 9224671 9211117 16925845
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9918713872 18071297 16109766 12540782 17562736 11743745 19370779 11287661 16177239 11461765 16081117 11739529 16485898 19739265 2444490 17906064 12392966 10915739 12594235 14725611 19420014 14550746 11834606 12705907 15968718 16781746 12958197 19416960 11529661 12153990 16227642 19923254 19164858 14986274 17522070 15619225 19085960 10663392 11421492 16393943 10774834
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.4811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D005124 Eye Abnormalities Tretinoin 3.8416938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D005355 Fibrosis Cyclosporine 10.3512168785 12639820
MESH:D005355 Fibrosis Tretinoin 10.3517994277
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0514991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006529 Hepatomegaly Phenobarbital 3.9716109766
MESH:D006930 Hyperalgesia Acetaminophen 8.6016870215
MESH:D006930 Hyperalgesia Tretinoin 8.6016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2717551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 6.4112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.418314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.3016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.3012371664
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1217596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3717649720 15748426 19225113 16331271 16823087 19035177 19029980 9834237 16788101 17107899 12679006 17712046 17506722 16766008 19075265 17368321 17294898 17339181 16891316 16935935 17361223 16140955 19642359 17301526 17217047
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0721047994
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 4.1719460945 16610002 19784758 12969438 19014921 11587558 16611625 12587719
MESH:D008107 Liver Diseases Phenobarbital 4.1719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 2.418742319 19073162 21047994 19812893 19482888 15975961
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.901399818 2563599 18308698 17172636 6150874
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009369 Neoplasms Tretinoin 2.5516946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7816049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Acetaminophen 7.6116870215
MESH:D010146 Pain Tretinoin 7.6116870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.6216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6215976015
MESH:D011230 Precancerous Conditions Cyclosporine 10.0712371664
MESH:D011230 Precancerous Conditions Phenobarbital 10.072563599
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 6.7118551238
MESH:D012640 Seizures Phenobarbital 6.713137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.111399818
MESH:D013964 Thyroid Neoplasms Tretinoin 8.1116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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