AutismKB 2.0

Annotation Detail for NUP160


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Basic Information Top
Gene Symbol:NUP160 ( DKFZp686M14102,MGC150678,MGC150679 )
Gene Full Name: nucleoporin 160kDa
Band: 11p11.2
Quick LinksEntrez ID:23279; OMIM: 607614; Uniprot ID:NU160_HUMAN; ENSEMBL ID: ENSG00000030066; HGNC ID: 18017
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of carbohydrates
Cell Cycle, Mitotic
DNA Replication
Transmembrane transport of small molecules
HIV Infection
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic NUP160 mRNA results in increased susceptibility to Arsenicincreases response to substance 17976673
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NUP160 mRNAincreases expression 17942748
C006253 pirinixic acid pirinixic acid results in decreased expression of NUP160 mRNAdecreases expression 17426115
D011374 Progesterone Progesterone results in increased expression of NUP160 mRNAincreases expression 18070364
D020849 Raloxifene Raloxifene results in increased expression of NUP160 mRNAincreases expression 16497877
D014810 Vitamin E Vitamin E results in decreased expression of NUP160 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.7317306315
MESH:D000419 Albuminuria Raloxifene 4.9817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D020261 Arsenic Poisoning Arsenic 2.9316251483 12569548 18414634 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D050197 Atherosclerosis Arsenic 3.4219371607 12928151
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.8617868700
MESH:D001930 Brain Injuries Progesterone 12.4015665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 12.4016580743
MESH:D001943 Breast Neoplasms Progesterone 2.3717614352 15562024 16175315
MESH:D001943 Breast Neoplasms Raloxifene 2.3715775269 17261762 17049068 15572757 17440819 16912660 17242785 15758505 17595753 17893378 16837676 17952589
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7517687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 2.3116507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7618922899 15504454 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 10.7018640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.7017572228
MESH:D002318 Cardiovascular Diseases Arsenic 8.2617938729 19152805 15738583
MESH:D002318 Cardiovascular Diseases Raloxifene 8.2615775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.6018022660 16973168
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5217681005 16105132 17110522 11677210 16919318 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 8.5219176532
MESH:D003072 Cognition Disorders Raloxifene 5.0415800139
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4517474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003928 Diabetic Nephropathies Raloxifene 4.2217308373 17451421 15920148
MESH:D003929 Diabetic Neuropathies Progesterone 4.9117187935
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004487 Edema pirinixic acid 7.9912083418
MESH:D004487 Edema Raloxifene 7.9915860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 17.7212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 17.7217692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 17.7215845917
MESH:D004715 Endometriosis Progesterone 4.0716134523
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.0715345470
MESH:D005234 Fatty Liver pirinixic acid 15.0720131406 19236843
MESH:D005234 Fatty Liver Raloxifene 15.0717473493
MESH:D005534 Foot Diseases Arsenic 6.086392382
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1316080930
MESH:D006331 Heart Diseases Raloxifene 3.7411110106
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 16221962 19772884 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7617050553
MESH:D006973 Hypertension Arsenic 5.9116076760 11953799 9931084
MESH:D006973 Hypertension Raloxifene 5.9115787275 17577099
MESH:D006987 Hypesthesia Arsenic 6.0816093927
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8215869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Progesterone 2.7415869954
MESH:D007251 Influenza, Human Vitamin E 4.7316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007642 Keratosis Arsenic 5.4512749816 16930632
MESH:D007674 Kidney Diseases Vitamin E 2.9612488133
MESH:D007889 Leiomyoma Raloxifene 4.8516973256
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7417339181
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4516169303
MESH:D008107 Liver Diseases Arsenic 2.6011134558
MESH:D008113 Liver Neoplasms Arsenic 4.9316368122
MESH:D008113 Liver Neoplasms pirinixic acid 4.9315890375 20007298 16377806
MESH:D008171 Lung Diseases Vitamin E 3.3716863852
MESH:D008175 Lung Neoplasms Arsenic 2.7319168569 17306315 17976673
MESH:D008175 Lung Neoplasms Vitamin E 2.7311062179
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0511408345 17203775
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6516497877
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D017202 Myocardial Ischemia Arsenic 4.2415371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009232 Myxoma Raloxifene 6.0816343187
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009436 Neural Tube Defects Arsenic 3.6416620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.7317056641
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010024 Osteoporosis Raloxifene 3.5717882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5815579764 15758505 17823083 17893378
MESH:D010051 Ovarian Neoplasms Arsenic 5.3317306315
MESH:D010051 Ovarian Neoplasms Progesterone 5.3317393432 16525653
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.4516905509 6392382 15371236
MESH:D011471 Prostatic Neoplasms Arsenic 2.6316140617
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6316536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6315084515
MESH:D011507 Proteinuria Arsenic 4.3521343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D011693 Purpura Raloxifene 6.0815770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9418045962
MESH:D012871 Skin Diseases Arsenic 5.2616353154 17938729 19834688 16759981 6392382 18709164 17548696 17050553 15952646 17453740 16702368
MESH:D012871 Skin Diseases Vitamin E 5.2618709164
MESH:D012878 Skin Neoplasms Arsenic 3.1317976673 16251483 17029826 17050553 19538983 15504454
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.7416503802 15862959
MESH:D020521 Stroke Raloxifene 9.5716837676
MESH:D020521 Stroke Vitamin E 9.5716517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013978 Tibial Fractures Raloxifene 5.7319048282
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.7411144890 19429237 17976673 18640142 19322015 17306315 15987713
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.7417572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014652 Vascular Diseases Arsenic 5.2017056641
MESH:D054556 Venous Thromboembolism Raloxifene 5.7316837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0816343187
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:474 Metabolism of carbohydrates
KEGG:03013 RNA transport
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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