AutismKB 2.0

Annotation Detail for CSTF2T


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Basic Information Top
Gene Symbol:CSTF2T ( CstF-64T,DKFZp434C1013,KIAA0689 )
Gene Full Name: cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
Band: 10q21.1
Quick LinksEntrez ID:23283; OMIM: 611968; Uniprot ID:CSTFT_HUMAN; ENSEMBL ID: ENSG00000177613; HGNC ID: 17086
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CSTF2T mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CSTF2T mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CSTF2T mRNAaffects cotreatment|increases expression 17942748
D007501 Iron Iron deficiency results in decreased expression of CSTF2T mRNAdecreases expression 20368581
C006253 pirinixic acid pirinixic acid results in decreased expression of CSTF2T mRNAdecreases expression 18445702
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CSTF2T mRNAaffects cotreatment|increases expression 17942748
D019772 Topotecan CSTF2T protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014807 Vitamin D Vitamin D affects the expression of CSTF2T mRNAaffects expression 20368581
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 6.0516640825
MESH:D000544 Alzheimer Disease Iron 3.0516640825 16563566
MESH:D000740 Anemia Iron 9.8216566752 16434484
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.8211748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.9117162259 17147795 16569441 17163184 17375513
MESH:D000756 Anemia, Sideroblastic Iron 5.0916910769
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001145 Arrhythmias, Cardiac Iron 4.6316604332
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001260 Ataxia Telangiectasia Iron 5.8515336622
MESH:D050197 Atherosclerosis Iron 3.8616640825 16632123
MESH:D001321 Autistic Disorder Acetaminophen 2.1518445737
MESH:D001321 Autistic Disorder Iron 2.1517352947
MESH:D001424 Bacterial Infections Iron 5.5916640825
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D009202 Cardiomyopathies Iron 4.2116640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.5416604332
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4217333356 16919318 11677210 16105132 17681005 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 8697196 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms Iron 2.9316640825
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003920 Diabetes Mellitus Iron 4.7016640825 16604332
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.4216506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 4.7416506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7417107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7817522070 11529661 12705907 10663392 11421492 19416960 19085960 16393943 15968718 11739529 17906064 12392966 11287661 16485898 19739265 12153990 10915739 18713872 16177239 19370779 15619225 17562736 16227642 12594235 14986274 11743745 19923254 12540782 19164858 10774834 12958197 16781746 16109766 14725611 2444490 11461765 11834606 14550746 19420014 18071297 16081117
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.8715345470
MESH:D005234 Fatty Liver Iron 14.8716640825
MESH:D005234 Fatty Liver pirinixic acid 14.8720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005621 Friedreich Ataxia Iron 5.7916604332 16640825
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006432 Hemochromatosis Iron 4.6816574947 16604332 16640825 17255318 17236123 17053826
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006486 Hemosiderosis Iron 5.6616604332
MESH:D006525 Hepatitis, Viral, Human Iron 5.9116640825
MESH:D006527 Hepatolenticular Degeneration Iron 5.3017182432
MESH:D006529 Hepatomegaly Iron 16.7016890145
MESH:D006529 Hepatomegaly pirinixic acid 16.7019772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.7015340226 12621046 16120746
MESH:D015658 HIV Infections Iron 3.8016597321
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007006 Hypogonadism Iron 4.5916640825
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007037 Hypothyroidism Iron 5.4416640825
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D019189 Iron Metabolism Disorders Iron 5.3417163184
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D015470 Leukemia, Myeloid, Acute Vitamin D 3.8320368581
MESH:D020961 Lewy Body Disease Iron 5.7916563566
MESH:D008103 Liver Cirrhosis Iron 3.8616640825
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6819784758 12969438 19460945 16611625 16610002 12587719 11587558 19014921
MESH:D008108 Liver Diseases, Alcoholic Iron 5.3617207112 16737972
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Iron 7.9820302851 16640825
MESH:D008113 Liver Neoplasms pirinixic acid 7.9816377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Iron 2.6516640825
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6519555203 11884234
MESH:D008268 Macular Degeneration Iron 4.1116640825
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 6.1217086897
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009181 Mycoses Iron 5.9116640825
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Iron 9.9216604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.9212213967
MESH:D015428 Myocardial Reperfusion Injury Iron 9.3316604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.3316411023
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009404 Nephrotic Syndrome Iron 4.7617178036
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009447 Neuroblastoma Topotecan 3.9715176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.3018514411
MESH:D019636 Neurodegenerative Diseases Iron 9.3016604332 17296847
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010003 Osteoarthritis Iron 4.1216640825
MESH:D010024 Osteoporosis Iron 8.5716640825 16648989
MESH:D010024 Osteoporosis Vitamin D 8.5717882678
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010212 Papilloma Iron 4.8412065085
MESH:D020447 Parasomnias Iron 6.4617352947
MESH:D010300 Parkinson Disease Iron 3.4016640825 16563566
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010900 Pituitary Diseases Iron 6.1216604332
MESH:D011041 Poisoning Iron 4.5916604332
MESH:D017119 Porphyria Cutanea Tarda Iron 12.1416640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 12.1418163543
MESH:D011225 Pre-Eclampsia Iron 4.6316640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11118676 11399792 11222880
MESH:D011528 Protozoan Infections Iron 6.4616640825
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012148 Restless Legs Syndrome Iron 4.7516930377
MESH:D012878 Skin Neoplasms Iron 6.2612065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.2616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013398 Sudden Infant Death Iron 5.8516640825
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D014376 Tuberculosis Iron 4.2416597321
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
KEGG:03015 mRNA surveillance pathway
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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