AutismKB 2.0

Annotation Detail for WWC1


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Basic Information Top
Gene Symbol:WWC1 ( FLJ10865,FLJ23369,HBEBP3,HBEBP36,KIAA0869,KIBRA )
Gene Full Name: WW and C2 domain containing 1
Band: 5q34
Quick LinksEntrez ID:23286; OMIM: 610533; Uniprot ID:KIBRA_HUMAN; ENSEMBL ID: ENSG00000113645; HGNC ID: 29435
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
AGING
memory disturbance
No data
Desease Name
Memory, enhanced, association with
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of WWC1 mRNAdecreases expression 19933214
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WWC1 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in decreased expression of WWC1 mRNAdecreases expression 20106945
D002945 Cisplatin WWC1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D010634 Phenobarbital Phenobarbital results in decreased expression of WWC1 mRNAdecreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of WWC1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of WWC1 mRNAaffects binding|decreases expression|increases activity 19710929
D020849 Raloxifene Raloxifene affects the expression of WWC1 mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of WWC1 mRNAdecreases expression 19933214
D014212 Tretinoin Tretinoin results in decreased expression of WWC1 mRNAdecreases expression 16604517
C025643 vinclozolin vinclozolin affects the expression of WWC1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.106195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1015322242 14514962 11752688
MESH:D058186 Acute Kidney Injury Cisplatin 4.1315814532 12690470 17670903
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Cisplatin 2.7917638652 11798837
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.7417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.7416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.7416835633
MESH:D000419 Albuminuria Raloxifene 4.7917308373 17451421
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.3019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.3012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.3016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.1514601052
MESH:D001930 Brain Injuries Raloxifene 4.6916580743
MESH:D001943 Breast Neoplasms Cisplatin 2.0018382427 19526202
MESH:D001943 Breast Neoplasms Raloxifene 2.0016912660 17440819 17261762 17952589 17242785 15775269 17595753 15572757 17893378 17049068 16837676 15758505
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D001943 Breast Neoplasms Tretinoin 2.0016873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.8217982673
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.8220007298 20935162 17173139 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.821917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0916685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.0017066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0016051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5615775269
MESH:D002386 Cataract Tretinoin 3.1917460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9412371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9815668235 16354765 12621046 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 5.989407595
MESH:D003072 Cognition Disorders Raloxifene 4.8315800139
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4916925845 9211117 9142499 10589399 9125849 9664655 17551590 9224671 8800419 14991402
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3117474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Raloxifene 4.0915920148 17308373 17451421
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Cisplatin 8.6012231392 12649298 19839026 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.6011462148
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004487 Edema pirinixic acid 12.4512083418
MESH:D004487 Edema Raloxifene 12.4515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.4512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.8518230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 12.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.1915845917
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.1411558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7620426865
MESH:D004938 Esophageal Neoplasms Cisplatin 4.7617638652 16481741 15173087 15464296 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.2611564622
MESH:D005124 Eye Abnormalities Tretinoin 9.269664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 14.1419224547
MESH:D005234 Fatty Liver pirinixic acid 14.1419236843 20131406
MESH:D005234 Fatty Liver Raloxifene 14.1417473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 16.0312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0320067830
MESH:D005355 Fibrosis Tretinoin 16.0317994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 8.2915102660 15464296
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.2916096774
MESH:D034381 Hearing Loss Cisplatin 4.4519898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5615464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.8114991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.6511110106
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Phenobarbital 15.6916109766
MESH:D006529 Hepatomegaly pirinixic acid 15.6919176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.6916120746 12621046 15340226
MESH:D006689 Hodgkin Disease Cisplatin 3.7416170182 16200630
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116354765 18606429 8697196 15340226 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.3516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 8.9210903974
MESH:D006973 Hypertension Raloxifene 8.9215787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.9218670907 18850075
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.5116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.5115992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.4115464296
MESH:D007674 Kidney Diseases Cisplatin 6.4912649298 18289764 15190930 19839026 12231392
MESH:D007674 Kidney Diseases Cyclosporine 6.4918776723 8314463 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.0611231351
MESH:D007889 Leiomyoma Raloxifene 4.6816973256
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2616331271 17294898 9834237 12679006 15748426 19075265 17368321 17339181 19035177 17361223 16766008 17506722 17217047 19642359 16140955 16935935 17649720 16823087 17107899 19029980 16788101 17301526 17712046 19225113 16891316
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9821047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4916248980 18397230
MESH:D008107 Liver Diseases Phenobarbital 2.2019363144
MESH:D008113 Liver Neoplasms Phenobarbital 7.688742319 21047994 19482888 19812893 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 7.6815890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6816984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.136150874 1399818 2563599 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1312151625
MESH:D008175 Lung Neoplasms Cisplatin 2.5117225452 11798837 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5111884234 19555203
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Cisplatin 3.5816248763 17023156 11135225 12393984 12374674 18176117 18332650 18505091 17761969 16809738 12883367 15577323 16432458
MESH:D008545 Melanoma Tretinoin 3.5816752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.0115990972
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D008654 Mesothelioma Cisplatin 3.3017638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8215863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5616497877
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009232 Myxoma Raloxifene 5.8216343187
MESH:D009369 Neoplasms Cisplatin 8.7516773208
MESH:D009369 Neoplasms pirinixic acid 8.7517405874
MESH:D009369 Neoplasms Tretinoin 8.7516594593 16946489
MESH:D009395 Nephritis, Interstitial Cisplatin 4.7615464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1814600291
MESH:D009421 Nervous System Malformations Tretinoin 10.189125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D009447 Neuroblastoma Cisplatin 3.538761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.938761367
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010024 Osteoporosis Raloxifene 3.4915775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4117823083 17893378 15758505 15579764
MESH:D010051 Ovarian Neoplasms Cisplatin 5.2019769630 6897625 15464296 17225452
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2016936753
MESH:D010146 Pain Tretinoin 3.0416870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 9.0119003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 9.0116965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 9.0115976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.5115464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.6117638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.4812371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.482563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2911118676 11896295 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.2918042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5816536755 15731164 16220300
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D011693 Purpura Raloxifene 5.8215770314
MESH:D051437 Renal Insufficiency Cisplatin 4.6215464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816283617 16116481
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.6314601052
MESH:D012640 Seizures Phenobarbital 2.8016876388 4039156 11442880 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
MESH:D012878 Skin Neoplasms Tretinoin 5.8016467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.6115464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.6617522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 2.6617261132
MESH:D020521 Stroke Raloxifene 3.9616837676
MESH:D013736 Testicular Neoplasms Cisplatin 4.8115464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.631399818
MESH:D013964 Thyroid Neoplasms Tretinoin 7.6316026305 17045167
MESH:D013978 Tibial Fractures Raloxifene 5.4719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.6512973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.6517572228
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 10.1216803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.1216129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.8215577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.4716837676
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D014839 Vomiting Cisplatin 4.9811897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA143485670
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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