AutismKB 2.0

Annotation Detail for SATB2


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Basic Information Top
Gene Symbol:SATB2 ( FLJ21474,FLJ32076,KIAA1034,MGC119474,MGC119477 )
Gene Full Name: SATB homeobox 2
Band: 2q33.1
Quick LinksEntrez ID:23314; OMIM: 608148; Uniprot ID:SATB2_HUMAN; ENSEMBL ID: ENSG00000119042; HGNC ID: 21637
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
ulcerative colitis
IMMUNE
Desease Name
Ulcerative colitis
Desease Name
Cleft palate and mental retardation
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SATB2 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SATB2 mRNAdecreases expression 15761015
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SATB2 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SATB2 mRNAaffects expression 20382639
D004958 Estradiol Estradiol affects the expression of SATB2 mRNAaffects expression 14699072
D008942 Mitoxantrone SATB2 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SATB2 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2414514962 11752688 15322242
MESH:D000230 Adenocarcinoma arsenic trioxide 7.4111798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.4120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.4111473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.9216206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.9212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7920146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.7912948864 17261762 17018787 19861407 17289903 16675129 18497071 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8112619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8115553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8116924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.2618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate marker/mechanism 16960803 19170718
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015340226 8697196 15668235 12621046 16354765
OMIM:119540 CLEFT PALATE, ISOLATED marker/mechanism
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities marker/mechanism 16960803
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 15322242 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.1519148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5620426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.5612903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver arsenic trioxide 3.5715073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8810048152 11294989
MESH:D006331 Heart Diseases Mitoxantrone 4.3316019553
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2512621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 16354765 16959395 18606429 15340226
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2115610895
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8818172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1716467208 20471514 19850784 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3819035177 17217047 16112521 17649720 17712046 16966277 9834237 12679006 19642359 16891316 12712474 16823087 12018890 11161223 15336539 19225113 19075265 16330433 11468182 15213294 15748426 17869043 17107899 15622746 16331271
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.449163691 2125692 18177683 15890375
MESH:D008113 Liver Neoplasms arsenic trioxide 11.4414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.4420195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.788603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.7820377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0414755239
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0411798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0420464547 20869020 17053015 20135361 18520028 20064080 6695378 18816296 18569708
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7217203775 11408345 16891317 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2915949261 11468182 19549372 19417148 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009369 Neoplasms Benzo(a)pyrene 5.7711141357
MESH:D009369 Neoplasms Mitoxantrone 5.7716640825
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 10.5816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.5814600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0719769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 5.0719401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4717292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.4716740699
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4220155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3511780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3517053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394624
    • No data
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443736Cleft Lip
    PA446836Craniofacial Abnormalities
    PA445190Osteoporosis
    PA443737Cleft Palate
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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