AutismKB 2.0

Annotation Detail for CUX2


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Basic Information Top
Gene Symbol:CUX2 ( CDP2,CUTL2 )
Gene Full Name: cut-like homeobox 2
Band: 12q24.11-q24.12
Quick LinksEntrez ID:23316; OMIM: 610648; Uniprot ID:CUX2_HUMAN; ENSEMBL ID: ENSG00000111249; HGNC ID: 19347
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CUX2 proteinaffects expression 20106945
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of CUX2 mRNAdecreases expression 17023530
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CUX2 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of CUX2 mRNAdecreases expression 20106945
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of CUX2 mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CUX2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CUX2 mRNAaffects cotreatment|increases expression 17942748
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of CUX2 mRNAincreases expression 12057914
D009151 Mustard Gas Mustard Gas results in increased expression of CUX2 mRNAincreases expression 15674843
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CUX2 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of CUX2 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in decreased expression of CUX2 mRNAdecreases expression 18070364
D011374 Progesterone Progesterone results in increased expression of CUX2 mRNAincreases expression 17404688
D013629 Tamoxifen Tamoxifen results in increased expression of CUX2 mRNAincreases expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CUX2 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CUX2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.4418653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 9.4418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.1511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1514692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001249 Asthma Mustard Gas 2.7410378619
MESH:D001768 Blister Mustard Gas 5.3119167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5117868700
MESH:D001930 Brain Injuries Progesterone 4.4015665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3520146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.3512948864 17261762 17289903 16675129 17018787 18497071 14630087 19861407
MESH:D001943 Breast Neoplasms Progesterone 2.3515562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 2.3515565566 17049068 19103187 19066611 19155303 19200415 19221464 20859285 16202921 17440819 19289846 19244106 18629630 16818667 20544844 21152245 18425577 18821012 19142967 18997820 20135344 18984771 19115204 20065188 15668708 16273361 18855134 16873071 11161223 17242785 18351453 20005174 19189210 19059307 17893378 19487384 18815881 17261762 19410462 19189212 20390343 21138602 19011961 19084267 19288272
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1517687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6816924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6816924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8218566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 13.8219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.8217681005 17333356 17110522 15861022 16919318 11677210 16105132
MESH:D002779 Cholestasis pirinixic acid 13.8219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.148697196 12621046 15668235 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.1719279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.1719279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6317187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema Mustard Gas 12.0711402378 9260866 11428631 11428647
MESH:D004487 Edema pirinixic acid 12.0712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.0711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.0912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 16.0917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.0919031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.6218566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6219155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Progesterone 9.2816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.2810568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.5515328337 17637181 15821434
MESH:D004890 Erythema Mustard Gas 5.319357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 19.6819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.6815345470
MESH:D005234 Fatty Liver pirinixic acid 19.6820131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 19.6819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005334 Fever Lipopolysaccharides 4.129205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Cyclosporine 8.9512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4916366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7316120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216959395 16354765 8697196 18606429 15340226
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Lipopolysaccharides 16.479205823 17963957 12878042 17255318 17237260
MESH:D007249 Inflammation Mustard Gas 16.4711428631 8975870 11402378 9260866 16001271 11428620 11428647 17524151 9357497
MESH:D007249 Inflammation Progesterone 16.4715869954
MESH:D007249 Inflammation Tamoxifen 16.4719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 16.4712878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.4316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.4316306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.7517255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.1418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.1415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9212371664
MESH:D007680 Kidney Neoplasms Estradiol 12.9215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 12.9218625569
MESH:D007970 Leukopenia Lipopolysaccharides 4.8515821434
MESH:D008064 Lipidoses Tamoxifen 3.2315342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.8614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.8612878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.8615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.8618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.8612878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.649163691 18177683 15890375 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.6421137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 14.6420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 14.6416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.038603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0312151625
MESH:D008171 Lung Diseases Mustard Gas 3.5218161513 18702808
MESH:D055370 Lung Injury Lipopolysaccharides 4.1521114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.7114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.7118569708 20869020 18816296 18520028 20464547 6695378 20135361 20064080 17053015
MESH:D008175 Lung Neoplasms Mustard Gas 6.718781369 3148597
MESH:D008175 Lung Neoplasms Tamoxifen 6.7118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7111884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.3811408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.3817203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.3811731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 13.2419453300
MESH:D020149 Manganese Poisoning Tamoxifen 13.2419453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.8916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8914600291
MESH:D009503 Neutropenia Mustard Gas 4.0916761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010051 Ovarian Neoplasms Estradiol 4.9719401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.9717393432 16525653
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D011014 Pneumonia Lipopolysaccharides 4.7111605937 12224865
MESH:D011041 Poisoning Mustard Gas 3.9115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4817292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.4816740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4815067354
MESH:D011537 Pruritus Ethinyl Estradiol 10.0515861022 16919318
MESH:D011537 Pruritus Mustard Gas 10.0518058305
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9617894541 10334151 17266442 17720292 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8010835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8918045962
MESH:D012871 Skin Diseases Mustard Gas 2.7416961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Progesterone 11.3915862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 11.3919457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2715821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1317053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.1316712894 8653321 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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