AutismKB 2.0

Annotation Detail for TRIM2


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Basic Information Top
Gene Symbol:TRIM2 ( KIAA0517,RNF86 )
Gene Full Name: tripartite motif-containing 2
Band: 4q31.3
Quick LinksEntrez ID:23321; OMIM: NA; Uniprot ID:TRIM2_HUMAN; ENSEMBL ID: ENSG00000109654; HGNC ID: 15974
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TRIM2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of TRIM2 mRNAincreases expression 20406850
C035208 2-amino-4,6-dinitrotoluene 2-amino-4,6-dinitrotoluene affects the expression of TRIM2 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of TRIM2 mRNAdecreases expression 16788091
D001280 Atrazine [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of TRIM2 mRNAaffects cotreatment|decreases expression 15654877
C006780 bisphenol A bisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of TRIM2 mRNA]decreases expression|decreases reaction 19228888
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TRIM2 mRNAaffects expression 17484886
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TRIM2 mRNAaffects cotreatment|affects expression 17602206
D003024 Clozapine Clozapine results in decreased expression of TRIM2 mRNAdecreases expression 14647396
D016572 Cyclosporine Cyclosporine results in increased expression of TRIM2 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TRIM2 mRNAaffects cotreatment|affects expression 17602206
D002117 Calcitriol Calcitriol results in increased expression of TRIM2 mRNAincreases expression 16002434
D004237 Diuron [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of TRIM2 mRNAaffects cotreatment|decreases expression 15654877
D004317 Doxorubicin TRIM2 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D005047 Etoposide TRIM2 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D005472 Fluorouracil TRIM2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D006220 Haloperidol Haloperidol results in decreased expression of TRIM2 mRNAdecreases expression 14647396
C028904 isoproturon [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of TRIM2 mRNAaffects cotreatment|decreases expression 15654877
D016685 Mitomycin TRIM2 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D008942 Mitoxantrone TRIM2 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D017239 Paclitaxel TRIM2 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TRIM2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of TRIM2 mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of TRIM2 mRNAincreases expression 19482888
D010656 Phenylephrine Phenylephrine results in decreased expression of TRIM2 mRNAdecreases expression 18158353
D013467 Sulindac Sulindac results in increased expression of TRIM2 mRNAincreases expression 11906190
D014284 Triiodothyronine bisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of TRIM2 mRNA]decreases expression|decreases reaction 19228888
D014284 Triiodothyronine Triiodothyronine results in decreased expression of TRIM2 mRNAdecreases expression 19228888
D019772 Topotecan TRIM2 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014212 Tretinoin Tretinoin results in increased expression of TRIM2 mRNAincreases expression 15977162
D014212 Tretinoin Tretinoin results in decreased expression of TRIM2 mRNAdecreases expression 16788091
D014747 Vinblastine TRIM2 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.2514745880
MESH:D000014 Abnormalities, Drug-Induced 2-amino-4,6-dinitrotoluene 8.267525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.266195326
MESH:D058186 Acute Kidney Injury Sulindac 4.107897758
MESH:D000230 Adenocarcinoma Doxorubicin 6.9217418594
MESH:D000230 Adenocarcinoma Fluorouracil 6.9217638652
MESH:D000230 Adenocarcinoma Sulindac 6.9211910360
MESH:D000236 Adenoma Diethylnitrosamine 6.5810737359 6695378
MESH:D000236 Adenoma Sulindac 6.5810223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.4517620307 19052882 17162532 16434500 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.4517620307
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.3916460482 11874996 11535846 17611924 12394442 15623613 19003578
MESH:D000380 Agranulocytosis Clozapine 4.8114617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Atrazine 3.9811874814
MESH:D000419 Albuminuria Doxorubicin 4.3121441931
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000740 Anemia Fluorouracil 3.5016511603 15504547 17963324
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9017460149
MESH:D001169 Arthritis, Experimental Tretinoin 2.9316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001321 Autistic Disorder Haloperidol 2.7619368416 18080171
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.3916197459 16206674
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.3314601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 11.3314601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.3415867366
MESH:D001862 Bone Resorption bisphenol A 3.6411985600
MESH:D001913 Bowen's Disease Sulindac 5.1011207687
MESH:D001919 Bradycardia Phenylephrine 4.3015306635
MESH:D001932 Brain Neoplasms Doxorubicin 3.6017150277
MESH:D001943 Breast Neoplasms bisphenol A 5.5817123778
MESH:D001943 Breast Neoplasms Calcitriol 5.5811237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.5817474063
MESH:D001943 Breast Neoplasms Doxorubicin 5.5811325840 18382427 15668708 15567936 16096432 17426702 15136595 16264153 18628466 18695136 19526202 15634643 17369602 16595493 15939500 16935488 17983394 15993339 16115903 16322301 18234424 15994142 15692762 16826403
MESH:D001943 Breast Neoplasms Etoposide 5.5816322251
MESH:D001943 Breast Neoplasms Fluorouracil 5.5815136595 16557594 16110121 18608205 18357371 16595493 19217205
MESH:D001943 Breast Neoplasms Paclitaxel 5.5818323546 16244791 18223236 16273361 16115903 15136595 18234424 11325840
MESH:D001943 Breast Neoplasms Sulindac 5.5816642371
MESH:D001943 Breast Neoplasms Tretinoin 5.5816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5416227642 18705752 15700767 16097048 15673190 3786805 10355542 16124888 16011737 16192424 16050911 15721981
MESH:D002276 Carcinoid Tumor Doxorubicin 11.5216051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.5216051944
MESH:D002277 Carcinoma Fluorouracil 3.3717121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 19.0816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 19.0816705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.0818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.0820084675 18788625 16807293 16681979 19052882 16540662 19335982 18506893 3084413 16288022 18785209 20514400 20524982 17173139 19701751 19383236 18393292 16328049 11831363 18665156 18210153 18971187 3581430 19418558 20007298 10672840 16779866 16830150 19519916 20432363 17428255 20512989 21159647 17162532 20935162 20727157 19822196 16569478 19394651 20101231 19171122 19107877 19208518 17761372 17138121 16502159 17978847 18691550 20214788 19539802 16935385 10737359 16698587 17055752 18494052 16878318 18978308 19919837 18056438
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 19.0816234567 16023760 17876044 18059187
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 19.0817971768 16332177 17088986 17045692 18930000 16799960
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 19.0816313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 19.086705139 17173139 20007298 1701930 20935162
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 19.081917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7417123778
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.261485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.2618695887
MESH:D002292 Carcinoma, Renal Cell Vinblastine 10.261485588
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.2211237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.226189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.2216757204 18986760 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.2216051514 16096774
MESH:D006332 Cardiomegaly Phenylephrine 3.4015728586 16170337 11754973 17287366 11179087 17124262
MESH:D009202 Cardiomyopathies Doxorubicin 3.3717131338 16731534 15476868 17924179 16364871 16242529 17007740 16455267 16612575 18627295 17308081 16269455 17329180 15811867 17519947 16278810 15505089 15792986 17928571 17974986 16651473 17351982 17382496 16109756 16952015
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8616243910 17334414
MESH:D002375 Catalepsy Haloperidol 4.661977408 15215559
MESH:D002386 Cataract Tretinoin 2.9517460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.186135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.1812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.182727394 7505956 17174075 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.014080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.4819052882
MESH:D002779 Cholestasis Cyclosporine 2.7419486331
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tretinoin 2.579407595
MESH:D003072 Cognition Disorders Clozapine 4.7217123785
MESH:D003092 Colitis Tretinoin 3.4617035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9218772588 15001691 17169374 17725105 17018589 16510598 17172411 17016597 16340194 17287894
MESH:D003110 Colonic Neoplasms Sulindac 3.9212902858 12458338
MESH:D015179 Colorectal Neoplasms Doxorubicin 6.2418259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 6.2418288408 17401013 17255274 16282729 15289873 18509181 17016601 18802399 17094418 16303861 18949393 16524972 14970324 17454858 17594712 15148649 18383874 18448328 16331619 16391804 17695437 20501625
MESH:D015179 Colorectal Neoplasms Paclitaxel 6.2418802399
MESH:D015179 Colorectal Neoplasms Sulindac 6.2418059344 10666051 11197048 11076880
MESH:D015179 Colorectal Neoplasms Vinblastine 6.2418802399
MESH:D000013 Congenital Abnormalities 2-amino-4,6-dinitrotoluene 4.9715095906
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.819224671 9664655 9142499 16925845 9211117 14991402 9125849 8800419 10589399 17551590
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.0918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.0918551238
MESH:D007644 Darier Disease Fluorouracil 4.5416733453
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.6120210726
MESH:D003704 Dementia Haloperidol 4.3611575062
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.4916402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4920387270
MESH:D003930 Diabetic Retinopathy Sulindac 4.9417621415 12861449
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.3015331141
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.2818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 14.2818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2-amino-4,6-dinitrotoluene 14.2821346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.2821278145 7440962 6884620 19085960 10915739 16227642 2869522 9327722 15027814 16177239 7179309 19336974 6623471 4309450 15968718 11566570 10092053 17522070 3732212 7120509 3786805 15998439
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.2819107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 14.2817416283
MESH:D004362 Drug Toxicity Doxorubicin 3.4918602426
MESH:D050171 Dyslipidemias Clozapine 4.0116402076
MESH:D004421 Dystonia Phenobarbital 3.781851702
MESH:D004489 Edema, Cardiac Tretinoin 4.2218230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.7015138306
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.0617359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.0616569247
MESH:D004715 Endometriosis Sulindac 4.2615652904
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9118037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.873659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.623922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.346401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.773659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.1016337965 16785472 15173087 16481741 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.1016481741
MESH:D004938 Esophageal Neoplasms Sulindac 7.1012235107
MESH:D005124 Eye Abnormalities Tretinoin 3.409664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 11.8312631006 16239168 16045604 15959796 12795759 19224547 61145 17595544
MESH:D005234 Fatty Liver Cyclosporine 11.8319224547
MESH:D005234 Fatty Liver Diethylnitrosamine 11.8321071580 20387270
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.2314745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.9719069698
MESH:D018222 Fibromatosis, Aggressive Sulindac 10.9719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 13.3918705752
MESH:D005355 Fibrosis Cyclosporine 13.3912168785 12639820
MESH:D005355 Fibrosis Tretinoin 13.3917994277
MESH:D005764 Gastroesophageal Reflux Sulindac 4.7811910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Doxorubicin 6.7217150277
MESH:D005909 Glioblastoma Tretinoin 6.7217312396
MESH:D005910 Glioma Fluorouracil 2.7716145905
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.0315692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.0318337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.0316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.7714991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 7.5117888722 16244372 12587719 16495754 14766674 16330681 16879835 17875725 16707910 16144979 16244371 18006777 18674790
MESH:D006331 Heart Diseases Mitoxantrone 7.5116019553
MESH:D006333 Heart Failure Doxorubicin 3.1917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6815692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3619110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 3.2516109766
MESH:D006561 Herpes Simplex Etoposide 4.3210809021
MESH:D006689 Hodgkin Disease Doxorubicin 11.3118501091 17606976 15147373
MESH:D006689 Hodgkin Disease Etoposide 11.3117606976 16200630 16135485 18180244 15147373
MESH:D006689 Hodgkin Disease Vinblastine 11.3118180244 18501091
MESH:D006930 Hyperalgesia Tretinoin 3.0216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006948 Hyperkinesis Clozapine 4.6616046005
MESH:D006973 Hypertension Cyclosporine 5.0610903974
MESH:D006973 Hypertension Phenylephrine 5.0612717712 8949925
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D006984 Hypertrophy Phenylephrine 4.3318502941 12791704
MESH:D007248 Infertility, Male Atrazine 3.5512948887
MESH:D007249 Inflammation Diethylnitrosamine 5.0118785209
MESH:D007249 Inflammation Sulindac 5.013291741
MESH:D007333 Insulin Resistance bisphenol A 3.1316393666
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D007414 Intestinal Neoplasms Sulindac 4.4212351151 12663524 10213222 10223192 12628509 12584176
MESH:D007417 Intestinal Polyps Sulindac 4.7611245490 12394442
MESH:D007569 Jaw Abnormalities Tretinoin 3.6817551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases Cyclosporine 5.648314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 5.6415699352 15369732 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.9316707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.1316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.1316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 16.1312371664
MESH:D007680 Kidney Neoplasms Fluorouracil 16.1316985049
MESH:D007938 Leukemia Tretinoin 2.6517143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9116085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6818172266
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.999834237 16140955 17339181 17301526 17107899 19029980 17712046 17649720 17368321 17506722 19642359 16331271 17217047 16935935 19035177 15748426 16823087 19225113 16788101 12679006 16891316 17361223 19075265 17294898 16766008
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008064 Lipidoses Clozapine 3.7917567588
MESH:D008080 Liposarcoma Paclitaxel 4.5917353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.2416943688 17334410 17174718 16239168 21278145 11903743 17157831 16221502 11408273
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.2418665156 20032147 18522880 19638242 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 10.2421047994
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.0712468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4012666154 18210741 15052691 12649538 14724832 16248980 18481824 15818738 16116963 12632512 12609069 12958196 18263696 17525996 17565644 15876570 20821823 10355542 15893842 18472094 14716833 12445418 17976157 15673190 18166357 12389079 16097048 12546737 17823541 18277467 15650968 17721639 17900296 15730626 16011737 13678700 18395095 18187930 18705752 12586293 17944888 16136751 15057751 12632514 16033810 12898905 15959796 14512876 14716496 18339082 18420326 15362042 18317297 14748882 16015684 17708605 11481614 17481882 17761835 18418968 18472332 18429990 17869086 15996030 18054572 16192424 15123356 18279442 15925388 16027843 15931870 12741479 17631135 14620537 17766677 18412020 15338365 17698563 17805973 12445421 18251166 17640975 15370692 12667390 17557913 18376398 17714472 18395914 18156304 16638106 18205269 18006644 17922224
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.4016595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4016248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.8815830285 16246199 15720792 17285989 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 8.8817034775
MESH:D008107 Liver Diseases Phenobarbital 8.8819363144
MESH:D008107 Liver Diseases Sulindac 8.8816867024 14986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4816899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.457678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.4519294768
MESH:D008113 Liver Neoplasms Clofibric Acid 20.4517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.4521071580 21047994 12112319 19427195 18978307 18644402 19850985 18754104 15175105 20492335 18648771 20405173 12771043 19833225 20137499 10737359 21278145 19256749 19090486 16942905 20101389 9163691 19642983 19073162 21167192 19426721 2862719 19255062 20118626 19690152 20501860 20434301 20583210 15885732 19638242 19996281 18977376 19812893 20452335 19294768 19499222 19254457 2422723 19551842
MESH:D008113 Liver Neoplasms Fluorouracil 20.4515113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Mitomycin 20.4515113037
MESH:D008113 Liver Neoplasms Phenobarbital 20.4519482888 8742319 19073162 19812893 15975961 21047994
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.046135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.0412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.0418093689 18544905 18164116 16267830 19126423 18775883 17942915 18079962 3124819 16842330 18253720 2563599 19004024 9362446 18282651 18308698 19519916 17854601 19009564 17174075 21159647 19539802
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 17.0417085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.0417172636 6150874 18308698 1399818 2563599
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.6820970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 4.686189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 4.6815246190
MESH:D008175 Lung Neoplasms Sulindac 4.6815713900 19359593
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5415086387
MESH:D008223 Lymphoma Doxorubicin 7.3316098063
MESH:D008223 Lymphoma Etoposide 7.3312854902 12556972
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.3017654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 8.3014749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 2.8815458769
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Doxorubicin 9.3416827129
MESH:D008545 Melanoma Paclitaxel 9.3416342250 12025231 12040289
MESH:D008545 Melanoma Sulindac 9.3416642371
MESH:D008545 Melanoma Tretinoin 9.3416752155
MESH:D008545 Melanoma Vinblastine 9.3417761969 16809738 16248763 12374674 15577320 18505091 18332650 15577323 16432458 18176117
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D001523 Mental Disorders Clozapine 7.5516856516
MESH:D001523 Mental Disorders Haloperidol 7.5516856516
MESH:D008654 Mesothelioma Atrazine 6.231916698
MESH:D008654 Mesothelioma Doxorubicin 6.2317638057
MESH:D024821 Metabolic Syndrome X Clozapine 4.2119142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2815792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4518986760 16757204
MESH:D052016 Mucositis Doxorubicin 4.5417415656
MESH:D009101 Multiple Myeloma Paclitaxel 3.5214749477
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9417596541
MESH:D009203 Myocardial Infarction Doxorubicin 2.8519429709 15857846
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2317484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.5218551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.049029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.0418259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 9.0415867366
MESH:D009369 Neoplasms Fluorouracil 7.7418239605 16928823 18600527
MESH:D009369 Neoplasms Mitoxantrone 7.7416640825
MESH:D009369 Neoplasms Tretinoin 7.7416946489 16594593
MESH:D009401 Nephrosis Doxorubicin 4.5316636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.6119348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.6115640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 9.0116427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 9.019125849
MESH:D009436 Neural Tube Defects Tretinoin 2.909142499
MESH:D009447 Neuroblastoma Doxorubicin 6.8715555623
MESH:D009447 Neuroblastoma Topotecan 6.8715176712
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.0420387270
MESH:D019636 Neurodegenerative Diseases Sulindac 8.0416850258 17266991
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2716436463
MESH:D009503 Neutropenia Vinblastine 4.3417378895
MESH:D009765 Obesity Clozapine 2.9619142110 18515891
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.1812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.1816049721
MESH:D010003 Osteoarthritis marker/mechanism 17568789
MESH:D010014 Osteolysis Paclitaxel 4.7315867366
MESH:D010018 Osteomalacia Phenobarbital 4.1217016548
MESH:D012516 Osteosarcoma Doxorubicin 3.9215930896
MESH:D010049 Ovarian Diseases bisphenol A 4.7411985600
MESH:D010051 Ovarian Neoplasms Paclitaxel 4.8311161223
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8316936753
MESH:D010146 Pain Sulindac 6.453291741
MESH:D010146 Pain Tretinoin 6.4516870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 23.5016540662
MESH:D010190 Pancreatic Neoplasms Etoposide 23.5019003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 23.5019003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Mitomycin 23.5015113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 23.5016965848
MESH:D010190 Pancreatic Neoplasms Sulindac 23.5016820089 11504793
MESH:D010190 Pancreatic Neoplasms Tretinoin 23.5015976015
MESH:D010300 Parkinson Disease Atrazine 3.1817218051
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9117983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9117638057
MESH:D011230 Precancerous Conditions Cyclosporine 14.0812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.082563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.082563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.7110548101
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5315572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.9920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8915754350 12479363 18247401 16644109 16289102
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8915897917 16868541 15749863 16729912 16888761 18437689
MESH:D011471 Prostatic Neoplasms Etoposide 1.8917172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8919082440 18626508
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8917172428 17136230 16356831 16729912
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.2512752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.7111575062
MESH:D011618 Psychotic Disorders Clozapine 8.5815331141
MESH:D011618 Psychotic Disorders Haloperidol 8.5811575062
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5410548101
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8018286688 15538739 18722050 16160472
MESH:D051437 Renal Insufficiency Doxorubicin 3.9817922066
MESH:D012135 Respiratory Sounds Atrazine 4.2811874814
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716283617 16116481
MESH:D012509 Sarcoma Doxorubicin 3.7817203757 18313854 15625365 15675481 17710206 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.7716326096 14601052
MESH:D012512 Sarcoma, Ewing's Etoposide 9.7714601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5417846226
MESH:D012559 Schizophrenia Clozapine 3.9717123785 18806925 20521326 20168265 20452607 18855531 20521320 20580759 11151749 20107430 11763009 17726453 19369910 16141801 17667964
MESH:D012559 Schizophrenia Haloperidol 3.9720107430 18513383 19369910 1830565
MESH:D012640 Seizures 2,4-dinitrotoluene 8.8518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.8518551238
MESH:D012640 Seizures Phenobarbital 8.853137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.576407741
MESH:D012852 Sinusitis Phenylephrine 4.467327846
MESH:D012878 Skin Neoplasms Doxorubicin 5.5115692506
MESH:D012878 Skin Neoplasms Tretinoin 5.5116467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3217203757 16767912 15625365
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5418456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.5418396642 17172411 17522103 15786421 18567086 17498489 16951190 19084572 16424979 19015929
MESH:D013274 Stomach Neoplasms Paclitaxel 4.5418396642 18506536
MESH:D013274 Stomach Neoplasms Tretinoin 4.5417261132
MESH:D019966 Substance-Related Disorders bisphenol A 3.7416684133 16045194
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.4720210726
MESH:D024801 Tauopathies Paclitaxel 4.5716930453
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.607505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 15.6017909728 16010429
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.601399818
MESH:D013964 Thyroid Neoplasms Tretinoin 15.6016026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 9.1216280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.1216051514
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.7716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.7716049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.7717653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.1710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.1710091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.7416803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.7416129372
MESH:D014591 Uterine Diseases bisphenol A 4.7614652134
MESH:D014594 Uterine Neoplasms Sulindac 4.3718645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.8015577323
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9817678736 17638931 17334414 16364871
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D015430 Weight Gain Clozapine 4.2620107430 17502770 20521320 16402076 16141801 20564506
MESH:D015431 Weight Loss Clozapine 4.8317933447
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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