AutismKB 2.0

Annotation Detail for NEDD4L


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NEDD4L ( FLJ33870,KIAA0439,NEDD4-2,RSP5,hNedd4-2 )
Gene Full Name: neural precursor cell expressed, developmentally down-regulated 4-like
Band: 18q21.31
Quick LinksEntrez ID:23327; OMIM: 606384; Uniprot ID:NED4L_HUMAN; ENSEMBL ID: ENSG00000049759; HGNC ID: 7728
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa04120Ubiquitin mediated proteolysis
hsa04960Aldosterone-regulated sodium reabsorption
No data
Pathway IDPathway Name
200128Neurotrophic factor-mediated Trk receptor signaling
200195TGF-beta receptor signaling
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
renin activity salt sensitivity
RENAL
hypertension
Hypotension, Orthostatic
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NEDD4L mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NEDD4L mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of NEDD4L mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NEDD4L mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NEDD4L mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of NEDD4L mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NEDD4L mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of NEDD4L mRNAincreases expression 20106945
C017180 decamethrin decamethrin results in increased expression of NEDD4L mRNAincreases expression 19017407
C014347 decitabine decitabine results in decreased expression of NEDD4L mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of NEDD4L mRNA]affects reaction|decreases expression 19363521
D004041 Dietary Fats Dietary Fats results in decreased expression of NEDD4L mRNAdecreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of NEDD4L mRNAdecreases expression 15171707
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NEDD4L mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of NEDD4L mRNAincreases expression 19619570
D004958 Estradiol Estradiol affects the expression of NEDD4L mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NEDD4L mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD4L mRNAaffects cotreatment|increases expression 17942748
D020366 Methylmethacrylate Methylmethacrylate results in increased expression of NEDD4L mRNAincreases expression 16916219
C041786 palm oil palm oil results in decreased expression of NEDD4L mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in decreased expression of NEDD4L mRNAdecreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of NEDD4L mRNAincreases expression 18301758
18445702
D011692 Puromycin Aminonucleoside Puromycin Aminonucleoside results in decreased expression of NEDD4L proteindecreases expression 16020936
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NEDD4L mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NEDD4L mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD4L mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NEDD4L mRNAincreases expression 18691609
D014635 Valproic Acid Valproic Acid results in increased expression of NEDD4L mRNAincreases expression 19101580
C111237 vorinostat vorinostat results in decreased expression of NEDD4L mRNAdecreases expression 17218635
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.446195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.4414514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.448875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8119490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.8120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.8111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.8114692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.586695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.5317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.5316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.5316835633
MESH:D000550 Amblyopia Valproic Acid 5.1017688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3515469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000799 Angioedema Acetaminophen 3.7110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.4717497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.4715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.4711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8519460635 18940202 16609825 17507914 18775368 18558336 19232924 15238991 18316065 18985861 17688650 20603192 18177632 18396377 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 3.0120046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7415746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.748888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6920146248 17474063
MESH:D001943 Breast Neoplasms decitabine 3.6919208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 3.6920435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.6915324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 3.6918497071 17289903 16675129 12948864 17261762 19861407 14630087 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6920435547
MESH:D001943 Breast Neoplasms vorinostat 3.6916144943
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6510355542 15700767 18705752 16227642 3786805 15673190 16124888 15721981 16097048 16050911 16011737 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.1116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.113084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.1118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 11.1115948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.1116924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.1117173139 20935162 20007298 6705139 1701930
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5520419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.5519215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3018670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.5110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.266135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.2620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.2612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.2618566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.124080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002779 Cholestasis Cyclosporine 12.7819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.7817681005 11677210 16105132 15861022 16919318 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 12.7819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0515668235 8697196 12621046 16354765 15340226
MESH:D003110 Colonic Neoplasms decitabine 2.3117616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9517141729 14669216
MESH:D019465 Craniofacial Abnormalities decamethrin 3.8619861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.8616575769 8888407 17688650
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.4312952375 16002989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3019279558
MESH:D003967 Diarrhea vorinostat 4.3720479100
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.5918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.5910774834 11287661 10663392 10915739 11421492 12153990 2444490 16781746 11529661 16081117 19370779 18071297 17562736 16177239 16485898 11834606 19164858 18713872 12392966 12705907 15619225 17906064 12540782 19085960 12594235 19739265 16393943 19416960 14550746 16227642 11743745 11461765 12958197 14986274 19923254 15968718 11739529 14725611 19420014 16109766 17522070
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.5915998439 6884620 19085960 7179309 11566570 3732212 7440962 3786805 10915739 15027814 2869522 10092053 16227642 19336974 16177239 7120509 15968718 6623471 9327722 21278145 17522070 4309450
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.5920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.591733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3618367378
MESH:D004421 Dystonia Phenobarbital 10.021851702
MESH:D004421 Dystonia Valproic Acid 10.021851702
MESH:D004487 Edema pirinixic acid 6.1412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0612538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9919294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.5616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.2615700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 7.2619148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.919294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.363659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.3617275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.543922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 9.543922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.4420417680
MESH:D004827 Epilepsy Valproic Acid 6.4418234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 8.496401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.497562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.877750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.877750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.043659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.043659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005221 Fatigue vorinostat 5.4620479100
MESH:D005234 Fatty Liver Carbon Tetrachloride 29.1515959796 19224547 12795759 16045604 12631006 16239168 17595544 61145
MESH:D005234 Fatty Liver Cyclosporine 29.1519224547
MESH:D005234 Fatty Liver Dietary Fats 29.1519551842 19004024 17967931 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.1515345470
MESH:D005234 Fatty Liver pirinixic acid 29.1519236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 29.1514986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5816002989 16513791 16534752 16611131 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.008888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 20.0618705752
MESH:D005355 Fibrosis Cyclosporine 20.0612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 20.0618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.0620067830
MESH:D005756 Gastritis Acetaminophen 3.5516983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.8216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.4019215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4719900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 13.6316109766
MESH:D006529 Hepatomegaly pirinixic acid 13.6318467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.6316120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.9015709030
MESH:D019584 Hot Flashes Estradiol 3.6217088409
MESH:D006849 Hydrocephalus Valproic Acid 4.7417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.928697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.6016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4016899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4921332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.3112960047 14722030
MESH:D006973 Hypertension marker/mechanism 18524855
MESH:D006973 Hypertension Cyclosporine 4.7810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9615338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.8116002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.8116945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.2315036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3412013081
MESH:D007248 Infertility, Male decitabine 6.4317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4317937319
MESH:D007249 Inflammation Dietary Fats 4.6920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.6912878042 12200463
MESH:D007299 Insect Bites and Stings decamethrin 5.6715189238
MESH:D007333 Insulin Resistance Dietary Fats 11.8018457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.8016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D007674 Kidney Diseases Acetaminophen 9.5415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.5418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.5415618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.8716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 16.8712371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.8715003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 16.8715610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9317184923
MESH:D007938 Leukemia decitabine 3.0119235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 3.8819117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9218704418 17679729 18460780 18206229 19010910 19387464
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9217596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3318055864
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.6121278145 16943688 11408273 11903743 17334410 16239168 16221502 17174718 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 10.6118296743
MESH:D008103 Liver Cirrhosis Phenobarbital 10.6121047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5815931870 18395095 12666154 16011737 12898905 16248980 15925388 17805973 16638106 18418968 14620537 17944888 18006644 15673190 18472332 15996030 12546737 17631135 15818738 18705752 18412020 17640975 12389079 18317297 17761835 17766677 17698563 13678700 17900296 18279442 16033810 14724832 14512876 20821823 15370692 18187930 17922224 12632512 17714472 12632514 16097048 15650968 15052691 12586293 16136751 12609069 18395914 15876570 18251166 18429990 12649538 15123356 18472094 18166357 18376398 17525996 17557913 15893842 17869086 12445421 16015684 11481614 17481882 17565644 17708605 15057751 12445418 16192424 18277467 10355542 17823541 18420326 18054572 12667390 14716496 18481824 14748882 18205269 18210741 17721639 12958196 18263696 12741479 18156304 16027843 17976157 16116963 18339082 15362042 15730626 14716833 15338365 15959796
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5815474484
MESH:D008106 Liver Cirrhosis, Experimental Puromycin Aminonucleoside 6.5816570917
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5812878042
MESH:D008107 Liver Diseases Acetaminophen 6.2811587558 16611625 19784758 12969438 19460945 19014921 12587719 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2816964402 15830285 17285989 16246199 15720792
MESH:D008107 Liver Diseases Phenobarbital 6.2819363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.0216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.0214706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.157678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.1521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.1519294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 21.1515890375 16712894
MESH:D008113 Liver Neoplasms Phenobarbital 21.158742319 19812893 19073162 19482888 15975961 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 21.1516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.1516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.436135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.4315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 13.432563599 17172636 18308698 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.4312151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1317228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.8917365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.1420869020 18520028 20064080 17053015 20464547 18816296 6695378 20135361 18569708
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.1411884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0215166399
MESH:D008223 Lymphoma decitabine 7.4219470736
MESH:D008223 Lymphoma Diethylstilbestrol 7.4215700306
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.5520479100
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3916002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4816891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.3519453300
MESH:D008545 Melanoma decitabine 2.2316505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4419513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1316166281 18303189 16966607
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1018765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0916381670
MESH:D009101 Multiple Myeloma decitabine 3.2518172295
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.918888407
MESH:D009190 Myelodysplastic Syndromes decitabine 7.2618608210 19157545 16882708 19010910
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.2617596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3417484760
MESH:D009325 Nausea vorinostat 5.4020479100
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7318551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 11.3411141357
MESH:D009369 Neoplasms decitabine 11.3419470736 19116145 17925555
MESH:D009369 Neoplasms Diethylstilbestrol 11.3415313581
MESH:D009369 Neoplasms pirinixic acid 11.3417405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6017289903
MESH:D009401 Nephrosis Puromycin Aminonucleoside 6.3715829708 11170791
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.5619348381 18481113
MESH:D009404 Nephrotic Syndrome Puromycin Aminonucleoside 9.5616020936
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.6411399458
MESH:D009421 Nervous System Malformations Estradiol 15.6416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.6414600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.0416359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7618514411
MESH:D009765 Obesity Dietary Fats 4.3220518802 21332399 20132043 18457598 11836018 19632207 18674790 16723640 17217161
MESH:D009765 Obesity pirinixic acid 4.3220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3216049721
MESH:D010018 Osteomalacia Phenobarbital 4.2317016548
MESH:D010051 Ovarian Neoplasms decitabine 4.7819259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 4.7819401270
MESH:D010146 Pain Acetaminophen 2.2916870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.2319294695
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.2316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5415687265 16977796
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.7610923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.6012371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.602563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 15.5117184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.5111896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.5120603192
MESH:D055728 Primary Myelofibrosis decitabine 4.6017616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1517292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.1515846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.1516740699
MESH:D011471 Prostatic Neoplasms vorinostat 2.1517218635
MESH:D011537 Pruritus Ethinyl Estradiol 3.1816919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 11.7612752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.7611422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9817365031 17322281 17975199 15814490
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.5619155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.5619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0515737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 9.3218551238
MESH:D012640 Seizures Phenobarbital 9.323137016 4039156 11442880 16876388
MESH:D012640 Seizures Valproic Acid 9.3214763951 16876388 3137016 11738929 11044598 1511512 15475178 17978042
MESH:D003294 Seizures, Febrile Phenobarbital 4.696407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.0419755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.048532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0416192470
MESH:D013088 Spermatocele Diethylstilbestrol 11.2816709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 11.2816709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6819490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.432093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 2.4319037991
MESH:D013921 Thrombocytopenia vorinostat 4.8520479100
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms decitabine 6.9717967635
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.971399818
MESH:D013978 Tibial Fractures Estradiol 4.5619048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.1017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.393119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.5316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.5317053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.5319087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.5316452187 16712894 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.518888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1910091137
MESH:D014581 Urticaria Acetaminophen 2.8510982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.9216175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.0515809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.0514692618
MESH:D014604 Uveal Neoplasms decitabine 4.7817785578
MESH:D014605 Uveitis Cyclosporine 3.851336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.3116513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D015430 Weight Gain Dietary Fats 3.6216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
Pathway ID Pathway Name
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:04144 Endocytosis
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31534
    • No data
    Releated disease ID Related disease Name
    PA447288Essential hypertension
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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