AutismKB 2.0

Annotation Detail for CLASP1


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Basic Information Top
Gene Symbol:CLASP1 ( DKFZp686D1968,DKFZp686H2039,FLJ33821,FLJ41222,KIAA0622,MAST1,MGC131895 )
Gene Full Name: cytoplasmic linker associated protein 1
Band: 2q14.2-q14.3
Quick LinksEntrez ID:23332; OMIM: 605852; Uniprot ID:CLAP1_HUMAN; ENSEMBL ID: ENSG00000074054; HGNC ID: 17088
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Axon guidance
No data
No data
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500380Centrosome maturation
500381Recruitment of mitotic centrosome proteins and complexes
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CLASP1 mRNAaffects expression 21346803
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CLASP1 mRNA]affects reaction|increases expression 18700144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CLASP1 mRNAdecreases expression 20064835
20106945
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CLASP1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of CLASP1 mRNAincreases expression 19482888
D012643 Selenium Selenium results in increased expression of CLASP1 mRNAincreases expression 18583539
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.986195326
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.5117620307
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.783084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.786705139 1701930 20935162 20007298 17173139
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.006135515
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D003092 Colitis Selenium 4.2617936198
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5018551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7014725611 16109766 16485898 17906064 11743745 19416960 11739529 16081117 14550746 19739265 16393943 14986274 11529661 11287661 17562736 16177239 18713872 10915739 18071297 19085960 12705907 11834606 11461765 12958197 12392966 16227642 12540782 19164858 19370779 11421492 12153990 19420014 16781746 15968718 10663392 2444490 10774834 12594235 17522070 19923254 15619225
MESH:D056486 Drug-Induced Liver Injury Selenium 6.7015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.483922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006333 Heart Failure Selenium 3.2717162251
MESH:D006529 Hepatomegaly Phenobarbital 3.9716109766
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D007251 Influenza, Human Selenium 4.8116624496
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2816705839
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0721047994
MESH:D008107 Liver Diseases Acetaminophen 4.1719014921 16611625 19460945 19784758 11587558 12969438 12587719 16610002
MESH:D008107 Liver Diseases Phenobarbital 4.1719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.097678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0920195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 8.0921047994 8742319 19073162 19812893 15975961 19482888
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.642876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.642563599 17172636 6150874 18308698 1399818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5717053015 20464547 18520028 18569708 18816296 20869020 20135361 20064080 6695378
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9715318939
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.4018551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7816049721
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5916965848
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011230 Precancerous Conditions Phenobarbital 3.952563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D012640 Seizures 2,6-dinitrotoluene 6.7118551238
MESH:D012640 Seizures Phenobarbital 6.713137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.321399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3516049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3517053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.8610091137
MESH:D014581 Urticaria Acetaminophen 3.3810982225
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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