Gene Symbol:	ESYT1 ( FAM62A,KIAA0747,MBC2 )
Gene Full Name:	extended synaptotagmin-like protein 1
Band:	12q13.2
Quick Links	Entrez ID:23344; OMIM: NA; Uniprot ID:ESYT1_HUMAN; ENSEMBL ID: ENSG00000139641; HGNC ID: 29534
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene affects the expression of ESYT1 mRNA	affects expression	21346803
D000082	Acetaminophen	Acetaminophen affects the expression of ESYT1 mRNA	affects expression	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ESYT1 mRNA	affects expression	16483693
D008727	Methotrexate	ESYT1 protein affects the susceptibility to Methotrexate	affects response to substance	16217747

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced	Methotrexate	4.87	12039119
MESH:D000138	Acidosis	Ammonium Chloride	4.19	18287403
MESH:D000799	Angioedema	Acetaminophen	4.57	10982225
MESH:D001172	Arthritis, Rheumatoid	Methotrexate	3.17	17286800
MESH:D001321	Autistic Disorder	Acetaminophen	1.40	18445737
MESH:D001943	Breast Neoplasms	Methotrexate	3.07	16978400
MESH:D006528	Carcinoma, Hepatocellular	2,6-dinitrotoluene	2.96	16705839
MESH:D006528	Carcinoma, Hepatocellular	Acetaminophen	2.96	3084413
MESH:D002386	Cataract	Acetaminophen	2.79	10977129
MESH:D002471	Cell Transformation, Neoplastic	2,6-dinitrotoluene	3.03	6135515
MESH:D019465	Craniofacial Abnormalities	Methotrexate	2.67	9562676 12039119
MESH:D003490	Cyanosis	2,6-dinitrotoluene	4.58	18551238
MESH:D003550	Cystic Fibrosis	Methotrexate	4.63	19747007
MESH:D003882	Dermatomyositis	Methotrexate	5.63	20191521
MESH:D056486	Drug-Induced Liver Injury	2,6-dinitrotoluene	4.02	18551238 21346803
MESH:D056486	Drug-Induced Liver Injury	Acetaminophen	4.02	16081117 10915739 11461765 11287661 19085960 12705907 15968718 18071297 16781746 19164858 16177239 12594235 17906064 10663392 14725611 17562736 12958197 16227642 11421492 10774834 19416960 14986274 16109766 11834606 19739265 11739529 17522070 19370779 15619225 19923254 16485898 19420014 12540782 12153990 11743745 2444490 18713872 16393943 12392966 11529661 14550746
MESH:D056487	Drug-Induced Liver Injury, Chronic	Acetaminophen	4.82	19426721
MESH:D005756	Gastritis	Acetaminophen	4.40	16983495
MESH:D006086	Graft vs Host Disease	Methotrexate	5.71	16518429
MESH:D006930	Hyperalgesia	Acetaminophen	3.02	16870215
MESH:D007674	Kidney Diseases	Acetaminophen	2.40	15629191 12587719
MESH:D007680	Kidney Neoplasms	2,6-dinitrotoluene	3.32	16705839
MESH:D007805	Language Development Disorders	Methotrexate	5.57	9562676
MESH:D008103	Liver Cirrhosis	Methotrexate	3.89	14986274
MESH:D008107	Liver Diseases	Acetaminophen	1.70	19014921 16610002 19784758 12969438 19460945 16611625 12587719 11587558
MESH:D017114	Liver Failure, Acute	Acetaminophen	3.63	16871587 17185352
MESH:D008113	Liver Neoplasms	2,6-dinitrotoluene	2.27	7678174
MESH:D008114	Liver Neoplasms, Experimental	2,6-dinitrotoluene	2.77	2876784 2876786 6135515
MESH:D017563	Lung Diseases, Interstitial	Methotrexate	5.74	18516814
MESH:D008223	Lymphoma	Methotrexate	4.22	17352296
MESH:D008546	Melanoma, Experimental	Acetaminophen	4.13	19513568
MESH:D052016	Mucositis	Methotrexate	5.91	17488658
MESH:D009336	Necrosis	2,6-dinitrotoluene	4.49	18551238 7678174
MESH:D019636	Neurodegenerative Diseases	Acetaminophen	3.21	18514411
MESH:D009784	Occupational Diseases	2,6-dinitrotoluene	3.83	16049721
MESH:D010146	Pain	Acetaminophen	2.73	16870215
MESH:D011565	Psoriasis	Methotrexate	3.54	17410198
MESH:D051437	Renal Insufficiency	Methotrexate	5.27	17352296
MESH:D012640	Seizures	2,6-dinitrotoluene	2.79	18551238
MESH:D013576	Syndactyly	Methotrexate	5.54	9562676
MESH:D001749	Urinary Bladder Neoplasms	2,6-dinitrotoluene	2.41	16049721
MESH:D014571	Urologic Neoplasms	2,6-dinitrotoluene	4.95	10091137
MESH:D014581	Urticaria	Acetaminophen	3.44	10982225

AutismKB 2.0

Annotation Detail for ESYT1

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics