Annotation Detail for SYNE1
Basic Information
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| Gene Symbol: | SYNE1 ( 8B,ARCA1,C6orf98,CPG2,DKFZp781J13156,EDMD4,FLJ30878,FLJ41140,KIAA0796,KIAA1262,KIAA1756,MYNE1,SCAR8,dJ45H2.2 ) |
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| Gene Full Name: | spectrin repeat containing, nuclear envelope 1 |
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| Band: | 6q25.2 |
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| Quick Links | Entrez ID:23345; OMIM: 608441; Uniprot ID:SYNE1_HUMAN; ENSEMBL ID: ENSG00000131018; HGNC ID: 17089 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Desease Name |
|---|
| ovarian cancer |
| CHEMDEPENDENCY |
| CANCER |
| tonometry |
| alcohol dependence |
| Desease Name |
|---|
| Tonometry |
| Bipolar disorder and major depressive disorder (combined) |
| Desease Name |
|---|
| Emery-Dreifuss muscular dystrophy 4 |
| Spinocerebellar ataxia, autosomal recessive 8 |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene results in decreased expression of SYNE1 mRNA | decreases expression | 20406850
|
| C111855 |
6-formylindolo(3,2-b)carbazole |
6-formylindolo(3,2-b)carbazole results in increased expression of SYNE1 mRNA | increases expression | 19799885
|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of SYNE1 mRNA | affects expression | 16483693
|
| D017638 |
Asbestos, Crocidolite |
Asbestos, Crocidolite results in increased expression of SYNE1 mRNA | increases expression | 18687144
|
| D016572 |
Cyclosporine |
Cyclosporine results in increased expression of SYNE1 mRNA | increases expression | 20106945
|
| D004997 |
Ethinyl Estradiol |
Ethinyl Estradiol results in decreased expression of SYNE1 mRNA | decreases expression | 17557909
|
| C006253 |
pirinixic acid |
pirinixic acid results in increased expression of SYNE1 mRNA | increases expression | 12832660
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
3.95 | 18287403 |
| MESH:D000152 |
Acne Vulgaris |
|
Ethinyl Estradiol |
4.38 | 17505938 |
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.42 | 18653653 |
| MESH:D000230 |
Adenocarcinoma |
|
Ethinyl Estradiol |
1.86 | 14692618 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
3.88 | 16434500 |
| MESH:D001161 |
Arteriosclerosis |
|
Ethinyl Estradiol |
3.82 | 11256880 |
| MESH:D001169 |
Arthritis, Experimental |
|
Ethinyl Estradiol |
2.82 | 15885639 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.43 | 19483382 |
| MESH:D001943 |
Breast Neoplasms |
marker/mechanism |
|
| 18507500 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
1.78 | 16705839 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
7.19 | 6135515 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Cyclosporine |
7.19 | 12371664 |
| MESH:D002779 |
Cholestasis |
|
Cyclosporine |
14.54 | 19486331 |
| MESH:D002779 |
Cholestasis |
|
Ethinyl Estradiol |
14.54 | 17681005 17110522 16919318 15861022 16105132 17333356 11677210 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
14.54 | 19176532 |
| MESH:D015179 |
Colorectal Neoplasms |
marker/mechanism |
|
| 21278247 18507500 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.38 | 18551238 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.53 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
2.03 | 18551238 21346803 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.76 | 12083418 |
| MESH:D004681 |
Encephalomyelitis, Autoimmune, Experimental |
|
Ethinyl Estradiol |
3.52 | 12538720 |
| MESH:D005234 |
Fatty Liver |
|
Cyclosporine |
14.70 | 19224547 |
| MESH:D005234 |
Fatty Liver |
|
Ethinyl Estradiol |
14.70 | 15345470 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
14.70 | 20131406 19236843 |
| MESH:D005355 |
Fibrosis |
|
Cyclosporine |
3.50 | 12168785 12639820 |
| MESH:D005885 |
Gingival Hyperplasia |
|
Cyclosporine |
4.62 | 8708960 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.69 | 20558911 |
| MESH:D006457 |
Hemoglobinuria, Paroxysmal |
|
Cyclosporine |
4.82 | 15720958 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.35 | 19772884 19176532 16221962 18467677 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.45 | 20558911 |
| MESH:D006973 |
Hypertension |
|
Cyclosporine |
2.18 | 10903974 |
| MESH:D007021 |
Hypospadias |
|
Ethinyl Estradiol |
4.17 | 16569931 16945680 |
| MESH:D007247 |
Infertility, Female |
|
Ethinyl Estradiol |
3.77 | 12013081 |
| MESH:D007248 |
Infertility, Male |
|
Ethinyl Estradiol |
2.66 | 17937319 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.80 | 16306350 |
| MESH:D007638 |
Keratoconjunctivitis Sicca |
|
Cyclosporine |
4.88 | 15604871 |
| MESH:D007674 |
Kidney Diseases |
|
Cyclosporine |
2.48 | 18776723 10903974 8314463 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
8.06 | 16705839 |
| MESH:D007680 |
Kidney Neoplasms |
|
Cyclosporine |
8.06 | 12371664 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
4.70 | 7678174 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
4.70 | 15890375 20007298 16377806 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.70 | 2876786 2876784 6135515 |
| MESH:D055370 |
Lung Injury |
|
Asbestos, Crocidolite |
4.38 | 17365036 |
| MESH:D008654 |
Mesothelioma |
|
Asbestos, Crocidolite |
3.27 | 18303189 16966607 16166281 |
| MESH:D008664 |
Metal Metabolism, Inborn Errors |
|
Cyclosporine |
5.23 | 16801185 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.86 | 16239165 |
| MESH:D020389 |
Muscular Dystrophy, Emery-Dreifuss |
marker/mechanism |
|
| |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.24 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.16 | 16411023 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.26 | 18551238 7678174 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.06 | 17405874 |
| MESH:D009402 |
Nephrosis, Lipoid |
|
Cyclosporine |
4.88 | 17954296 |
| MESH:D009404 |
Nephrotic Syndrome |
|
Cyclosporine |
3.53 | 18481113 19348381 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.86 | 20558911 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
3.70 | 16049721 |
| MESH:D016584 |
Panic Disorder |
|
Ethinyl Estradiol |
3.99 | 11578682 |
| MESH:D010995 |
Pleural Diseases |
|
Asbestos, Crocidolite |
5.25 | 10923243 |
| MESH:D011230 |
Precancerous Conditions |
|
Cyclosporine |
3.47 | 12371664 |
| MESH:D011537 |
Pruritus |
|
Ethinyl Estradiol |
3.71 | 15861022 16919318 |
| MESH:D011565 |
Psoriasis |
|
Cyclosporine |
2.30 | 16882103 |
| MESH:D011658 |
Pulmonary Fibrosis |
|
Asbestos, Crocidolite |
3.11 | 17322281 17365031 15814490 17975199 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.50 | 19058328 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.71 | 18551238 |
| MESH:D013088 |
Spermatocele |
|
Ethinyl Estradiol |
4.38 | 16709447 |
| OMIM:610743 |
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 8 |
marker/mechanism |
|
| |
| MESH:D019851 |
Thrombophilia |
|
Ethinyl Estradiol |
3.92 | 11994571 |
| MESH:D013927 |
Thrombosis |
|
Ethinyl Estradiol |
3.40 | 15669648 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
2.38 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
4.71 | 10091137 |
| MESH:D014594 |
Uterine Neoplasms |
|
Ethinyl Estradiol |
3.63 | 14692618 |
| MESH:D014605 |
Uveitis |
|
Cyclosporine |
4.43 | 1336536 |
| MESH:D020246 |
Venous Thrombosis |
|
Ethinyl Estradiol |
3.82 | 15869587 14671159 |
| MESH:D014985 |
Xerophthalmia |
|
Cyclosporine |
4.88 | 17120751 |
PharmGKB Accession:PA134975331
| Releated disease ID |
Related disease Name |
| PA443756 | Colonic Neoplasms |
Related Pathway Information