Annotation Detail for UBR4
Basic Information
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| Gene Symbol: | UBR4 ( FLJ41863,KIAA0462,KIAA1307,RBAF600,ZUBR1,p600 ) |
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| Gene Full Name: | ubiquitin protein ligase E3 component n-recognin 4 |
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| Band: | 1p36.13 |
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| Quick Links | Entrez ID:23352; OMIM: 609890; Uniprot ID:UBR4_HUMAN; ENSEMBL ID: ENSG00000127481; HGNC ID: 30313 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of UBR4 mRNA | affects expression | 21346803
|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of UBR4 mRNA | affects expression | 17562736
|
| C447119 |
bazedoxifene acetate |
bazedoxifene acetate results in increased expression of UBR4 mRNA | increases expression | 19914376
|
| D016572 |
Cyclosporine |
Cyclosporine results in increased expression of UBR4 mRNA | increases expression | 20106945
|
| D007657 |
Ketone Bodies |
Ketone Bodies results in increased expression of UBR4 mRNA | increases expression | 16807920
|
| C006253 |
pirinixic acid |
pirinixic acid results in decreased expression of UBR4 mRNA | decreases expression | 17426115
|
| C025643 |
vinclozolin |
vinclozolin affects the expression of UBR4 mRNA | affects expression | 19015723
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.42 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
3.88 | 16434500 |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.29 | 10982225 |
| MESH:D001008 |
Anxiety Disorders |
|
vinclozolin |
3.86 | 19015723 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.40 | 18445737 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.43 | 19483382 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
2.92 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
2.92 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.73 | 10977129 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
7.19 | 6135515 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Cyclosporine |
7.19 | 12371664 |
| MESH:D002779 |
Cholestasis |
|
Cyclosporine |
8.44 | 19486331 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
8.44 | 19176532 |
| MESH:D003456 |
Cryptorchidism |
|
vinclozolin |
4.67 | 14966744 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.38 | 18551238 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.53 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
3.94 | 18551238 21346803 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
3.94 | 19416960 19085960 18713872 15968718 11529661 17522070 11743745 12705907 10663392 11287661 12540782 19739265 14550746 16081117 11461765 10774834 16781746 12958197 14725611 14986274 11739529 17562736 12153990 19923254 11834606 10915739 19420014 16485898 18071297 15619225 2444490 16393943 19370779 11421492 17906064 19164858 16109766 12392966 16227642 16177239 12594235 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.54 | 19426721 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.76 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
Cyclosporine |
8.51 | 19224547 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
8.51 | 19236843 20131406 |
| MESH:D005355 |
Fibrosis |
|
Cyclosporine |
3.50 | 12168785 12639820 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.12 | 16983495 |
| MESH:D030342 |
Genetic Diseases, Inborn |
|
vinclozolin |
5.33 | 16973722 |
| MESH:D005832 |
Genital Diseases, Male |
|
vinclozolin |
5.74 | 16417039 |
| MESH:D005885 |
Gingival Hyperplasia |
|
Cyclosporine |
4.62 | 8708960 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.69 | 20558911 |
| MESH:D006457 |
Hemoglobinuria, Paroxysmal |
|
Cyclosporine |
4.82 | 15720958 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.35 | 16221962 19176532 18467677 19772884 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
2.92 | 16870215 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.45 | 20558911 |
| MESH:D006973 |
Hypertension |
|
Cyclosporine |
2.18 | 10903974 |
| MESH:D007248 |
Infertility, Male |
|
vinclozolin |
3.21 | 16467254 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.80 | 16306350 |
| MESH:D007638 |
Keratoconjunctivitis Sicca |
|
Cyclosporine |
4.88 | 15604871 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
6.28 | 12587719 15629191 |
| MESH:D007674 |
Kidney Diseases |
|
Cyclosporine |
6.28 | 8314463 18776723 10903974 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
8.06 | 16705839 |
| MESH:D007680 |
Kidney Neoplasms |
|
Cyclosporine |
8.06 | 12371664 |
| MESH:D007984 |
Leydig Cell Tumor |
|
vinclozolin |
5.13 | 16417039 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.68 | 19014921 12969438 16610002 16611625 11587558 19784758 12587719 19460945 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.50 | 17185352 16871587 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
4.70 | 7678174 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
4.70 | 16377806 15890375 20007298 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.70 | 2876786 6135515 2876784 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
3.93 | 19513568 |
| MESH:D008664 |
Metal Metabolism, Inborn Errors |
|
Cyclosporine |
5.23 | 16801185 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.86 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.24 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.16 | 16411023 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.26 | 18551238 7678174 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.06 | 17405874 |
| MESH:D009402 |
Nephrosis, Lipoid |
|
Cyclosporine |
4.88 | 17954296 |
| MESH:D009404 |
Nephrotic Syndrome |
|
Cyclosporine |
3.53 | 18481113 19348381 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.10 | 18514411 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.86 | 20558911 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
3.70 | 16049721 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.62 | 16870215 |
| MESH:D011230 |
Precancerous Conditions |
|
Cyclosporine |
3.47 | 12371664 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
vinclozolin |
4.29 | 18220299 19015723 18042343 |
| MESH:D011469 |
Prostatic Diseases |
|
vinclozolin |
5.33 | 18220299 |
| MESH:D011472 |
Prostatitis |
|
vinclozolin |
5.33 | 18629315 |
| MESH:D011565 |
Psoriasis |
|
Cyclosporine |
2.30 | 16882103 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.50 | 19058328 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.71 | 18551238 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
2.38 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
4.71 | 10091137 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.28 | 10982225 |
| MESH:D014605 |
Uveitis |
|
Cyclosporine |
4.43 | 1336536 |
| MESH:D014985 |
Xerophthalmia |
|
Cyclosporine |
4.88 | 17120751 |
Related Pathway Information