AutismKB 2.0

Annotation Detail for FNBP4


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Basic Information Top
Gene Symbol:FNBP4 ( DKFZp686M14102,DKFZp779I1064,FBP30,FLJ41904,KIAA1014 )
Gene Full Name: formin binding protein 4
Band: 11p11.2
Quick LinksEntrez ID:23360; OMIM: NA; Uniprot ID:FNBP4_HUMAN; ENSEMBL ID: ENSG00000109920; HGNC ID: 19752
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FNBP4 mRNAaffects expression 21346803
C006632 arsenic trioxide arsenic trioxide results in increased expression of FNBP4 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FNBP4 mRNAdecreases expression 20018196
19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of FNBP4 mRNAdecreases expression 16239168
D016572 Cyclosporine Cyclosporine results in increased expression of FNBP4 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FNBP4 mRNAaffects expression 17555576
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FNBP4 mRNAaffects binding|increases activity|increases expression 19710929
D013629 Tamoxifen Tamoxifen affects the expression of FNBP4 mRNAaffects expression 17555576
D014810 Vitamin E Vitamin E results in decreased expression of FNBP4 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4411798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4414692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.6919483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1919221464 16818667 17049068 19410462 19487384 20065188 17440819 19244106 19115204 21138602 17893378 19288272 15565566 20005174 20544844 17261762 18815881 20390343 18855134 21152245 19189212 18821012 19142967 18425577 19189210 18997820 18629630 20859285 16202921 19103187 19084267 20135344 19011961 11161223 15668708 16273361 18351453 19289846 19155303 16873071 19066611 17242785 19059307 18984771 19200415
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.8115700767 16050911 15721981 10355542 15673190 18705752 16227642 3786805 16124888 16192424 16097048 16011737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.8116050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8116705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8115073043 14691202 11135700 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8118788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8116924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0112371664
MESH:D002779 Cholestasis Cyclosporine 14.2319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.2317681005 11677210 16919318 15861022 16105132 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 14.2319176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7610525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7619769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0521278145 11566570 15968718 16177239 16227642 7440962 2869522 19085960 10915739 10092053 17522070 3786805 4309450 7179309 9327722 3732212 7120509 15027814 6884620 15998439 6623471 19336974
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1719155303 16202921 17893378 20544844
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6120426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6112903497
MESH:D005234 Fatty Liver arsenic trioxide 33.7215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.7215959796 19224547 12795759 61145 12631006 16239168 17595544 16045604
MESH:D005234 Fatty Liver Cyclosporine 33.7219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.7215345470
MESH:D005234 Fatty Liver pirinixic acid 33.7219236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 33.7219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.5418705752
MESH:D005355 Fibrosis Cyclosporine 9.5412168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0816080930
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.2519176532 16221962 18467677 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tamoxifen 2.4519457130
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.388314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 6.3812488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.4016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.4012371664
MESH:D007680 Kidney Neoplasms Tamoxifen 13.4018625569
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 20471514 16968895 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3417649720 17107899 15213294 11468182 12712474 15622746 19075265 16966277 9834237 15748426 16891316 16331271 17712046 12679006 19035177 16112521 19642359 12018890 16823087 16330433 17217047 15336539 11161223 19225113 17869043
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008064 Lipidoses Tamoxifen 3.3017567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9111408273 21278145 11903743 16239168 16221502 17334410 16943688 17174718 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1217525996 18210741 18339082 16638106 18395095 18251166 15362042 16136751 16011737 14620537 12445421 15925388 15123356 14716496 18705752 17761835 17640975 12632514 18166357 17922224 17766677 16015684 18481824 18006644 15959796 17708605 13678700 12389079 17565644 15370692 17944888 17900296 18317297 17805973 15057751 16248980 16116963 18412020 18420326 18277467 12958196 17714472 17631135 16033810 12632512 15338365 16192424 17869086 18263696 15931870 15876570 18054572 14724832 17481882 14716833 15818738 12667390 16097048 17976157 14748882 12609069 18472332 15893842 18472094 18418968 12649538 15650968 15052691 18156304 12445418 11481614 12898905 20821823 14512876 18187930 12666154 18205269 18376398 17721639 17823541 18429990 17698563 18279442 18395914 10355542 17557913 12741479 15730626 16027843 12586293 15673190 12546737 15996030
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1215474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.1218564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.1216169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215830285 16964402 15720792 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8816899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 11.2714682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.2719294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.2716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 11.2716684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.3920377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3912014681 15583823
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5811798837 19825857
MESH:D008175 Lung Neoplasms Tamoxifen 3.5818625569
MESH:D008175 Lung Neoplasms Vitamin E 3.5811062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7411731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2515949261 19417148 11468182 14977855 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219196722 19200415 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6216049721 12819281
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4619769630 16624393 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5419131511
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5415067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5415084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7316049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.7320435036 11780464 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.7316712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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