AutismKB 2.0

Annotation Detail for PSD3


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Basic Information Top
Gene Symbol:PSD3 ( DKFZp761K1423,EFA6R,HCA67 )
Gene Full Name: pleckstrin and Sec7 domain containing 3
Band: 8p22
Quick LinksEntrez ID:23362; OMIM: NA; Uniprot ID:PSD3_HUMAN; ENSEMBL ID: ENSG00000156011; HGNC ID: 19093
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PSD3 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of PSD3 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PSD3 mRNAdecreases expression 19128835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PSD3 mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PSD3 mRNAaffects expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PSD3 mRNAincreases expression 15336504
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PSD3 mRNAaffects expression 17555576
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PSD3 mRNAaffects cotreatment|increases expression 17183730
D013629 Tamoxifen Tamoxifen affects the expression of PSD3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PSD3 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PSD3 mRNAdecreases expression 19933214
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PSD3 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9715322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.978875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma arsenic trioxide 7.2219825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2220127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2214692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8617507914 19232924 18316065 18940202 18558336 18396377 17157402 16609825 17688650 18177632 18985861 15238991 20603192 19460635 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.1420046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.4316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3115746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.318888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7917474063 20146248
MESH:D001943 Breast Neoplasms Tamoxifen 1.7919142967 20859285 16202921 18821012 19221464 19410462 11161223 16818667 15565566 19059307 19289846 19200415 18351453 19487384 19189212 20390343 19103187 17049068 19115204 21138602 18815881 17242785 20005174 15668708 20544844 16273361 18984771 17261762 17893378 19288272 19155303 21152245 18629630 19011961 18855134 16873071 19189210 19244106 20135344 19066611 18425577 19084267 18997820 20065188 17440819
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.653084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6515553829 16217749 14691202 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6516924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8220889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9816105132 16919318 17681005 17110522 15861022 17333356 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 8697196 15340226 15668235 16354765
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.8416575769 8888407 17688650
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6019279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3614550746 10915739 11529661 17562736 19923254 15968718 2444490 12958197 11739529 11287661 10663392 12705907 12153990 16485898 11461765 17522070 19164858 11421492 15619225 10774834 18713872 18071297 19739265 16781746 19416960 14725611 19420014 17906064 12594235 16227642 12540782 16109766 11743745 11834606 16081117 19370779 14986274 16177239 19085960 16393943 12392966
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3620420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.361733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.4919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1317893378 16202921 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.333659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.716426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.4012903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver arsenic trioxide 19.9915073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.9915345470
MESH:D005234 Fatty Liver Tamoxifen 19.9919224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 19.9914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2918558336 8888407
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005910 Glioma marker/mechanism 16865689
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8016612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Tamoxifen 5.1119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1618625569
MESH:D007938 Leukemia arsenic trioxide 2.8915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9817050201 16467208 19850784 16968895 20471514
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9817596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3016823087 12018890 12712474 11161223 17712046 17217047 17107899 16966277 11468182 16891316 16112521 15213294 15336539 19225113 19075265 12679006 16330433 17869043 9834237 15622746 19642359 17649720 19035177 15748426 16331271
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D008064 Lipidoses Tamoxifen 3.2515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008107 Liver Diseases Acetaminophen 1.6619460945 12587719 19784758 19014921 12969438 16611625 11587558 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 11.0914682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0921137059 20195826
MESH:D008113 Liver Neoplasms Tamoxifen 11.0916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0916984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.0820377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9419825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9420464547 6695378 18569708 17053015 18520028 20869020 20064080 20135361 18816296
MESH:D008175 Lung Neoplasms Tamoxifen 4.9418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9411884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7114580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008881 Migraine Disorders Valproic Acid 3.2918765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2019417148 14977855 15949261 19549372 11468182
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.6716882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.6717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6210525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.628888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4416624393 12452020 19769630
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5715580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.1211118676 11222880 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.1220603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5017292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.7611422049 12752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8311044598 14763951 11738929 17978042 1511512 16876388 15475178 3137016
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.7510029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.3016709447
MESH:D013088 Spermatocele Tamoxifen 12.3016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4020155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.5912845720 11780464 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5917053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.5917572228 8653321 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:04144 Endocytosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394629
    • No data
    Releated disease ID Related disease Name
    PA446714Neoplasm, Residual
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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