AutismKB 2.0

Annotation Detail for OBSL1


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Basic Information Top
Gene Symbol:OBSL1 ( KIAA0657,MGC71026 )
Gene Full Name: obscurin-like 1
Band: 2q35
Quick LinksEntrez ID:23363; OMIM: 610991; Uniprot ID:A4KVA4_HUMAN; ENSEMBL ID: ENSG00000124006; HGNC ID: 29092
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of OBSL1 mRNAincreases expression 15761015
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of OBSL1 mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of OBSL1 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of OBSL1 mRNAincreases expression 16239168
D012643 Selenium Selenium results in increased expression of OBSL1 mRNAincreases expression 19244175
D014635 Valproic Acid Valproic Acid results in increased expression of OBSL1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9918177632 17507914 19232924 18940202 17688650 18558336 19460635 20603192 18775368 18985861 16609825 15238991 18396377 17157402 18316065
MESH:D001714 Bipolar Disorder Valproic Acid 3.2117594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.0016206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016124888 16192424 16097048 16050911 10355542 15700767 3786805 16227642 18705752 15673190 16011737 15721981
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1714691202 15073043 16217749 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1718788625
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D003110 Colonic Neoplasms marker/mechanism 19050079
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7810525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.788888407 17688650 16575769
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.744309450 7179309 17522070 10092053 11566570 3732212 2869522 7120509 6623471 3786805 21278145 19336974 15998439 6884620 10915739 15027814 16227642 7440962 19085960 16177239 15968718 9327722
MESH:D056486 Drug-Induced Liver Injury Selenium 6.7415131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.741733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.443922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.876426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6820426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6812903497
MESH:D005234 Fatty Liver arsenic trioxide 15.1515073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.1519224547 15959796 16239168 12631006 16045604 12795759 17595544 61145
MESH:D005234 Fatty Liver Valproic Acid 15.1514986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.518888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8718705752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D006333 Heart Failure Selenium 3.2517162251
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719900420 19110552
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007251 Influenza, Human Selenium 4.7216624496
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0617050201 20471514 19850784 16968895 16467208
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0616294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4117712046 17869043 9834237 17217047 15213294 16330433 16891316 16112521 19642359 15336539 19035177 16331271 16823087 19225113 19075265 15748426 15622746 11161223 17649720 16966277 12712474 17107899 12018890 11468182 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9617334410 16239168 11408273 17174718 21278145 11903743 16943688 16221502 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7518187930 14716833 18418968 17900296 15876570 15959796 10355542 16015684 15893842 18395914 12586293 17761835 17640975 17557913 18339082 12666154 18317297 17823541 20821823 14512876 13678700 16638106 16116963 15370692 12741479 14716496 11481614 15931870 18279442 12546737 12445421 18006644 12667390 14620537 17976157 18263696 17721639 17869086 18429990 12389079 16248980 18277467 17631135 16097048 12609069 12649538 16027843 14748882 16192424 15818738 14724832 18472332 18166357 16033810 17944888 17922224 17805973 18054572 18481824 15052691 18205269 17714472 15362042 18376398 15338365 18251166 12958196 17481882 17525996 16136751 18420326 18412020 12632512 15925388 15673190 12898905 17565644 17708605 18156304 17698563 16011737 18472094 15650968 12445418 18395095 12632514 15123356 15730626 15996030 18705752 15057751 18210741 17766677
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1416964402 17285989 15830285 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9914706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9614682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.9619294768
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.6020377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.6012014681 15583823
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D008881 Migraine Disorders Valproic Acid 3.4118803445 18765137
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3214977855 15949261 11468182 19417148 19549372
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.9616105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.9617596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 19050079
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9710525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.9716359493 8888407
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4812452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6115580305
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2920603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D019310 Pseudolymphoma Valproic Acid 5.0611422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9415475178 11044598 16876388 14763951 11738929 3137016 17978042 1511512
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.818532709
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
OMIM:612921 THREE M SYNDROME 2 marker/mechanism
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5811780464 20435036 12973940 12845720
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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