Annotation Detail for LARP1
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C016403 |
2,4-dinitrotoluene |
2,4-dinitrotoluene affects the expression of LARP1 mRNA | affects expression | 21346803
|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of LARP1 mRNA | affects expression | 21346803
|
| C035207 |
4-amino-2,6-dinitrotoluene |
4-amino-2,6-dinitrotoluene affects the expression of LARP1 mRNA | affects expression | 21346803
|
| D002995 |
Clofibric Acid |
Clofibric Acid affects the expression of LARP1 mRNA | affects expression | 17602206
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LARP1 mRNA | affects binding|increases activity|increases expression | 19710929
|
| C010327 |
salinomycin |
salinomycin results in decreased expression of LARP1 mRNA | decreases expression | 19682730
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
4-amino-2,6-dinitrotoluene |
4.41 | 7525203 |
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.47 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
3.94 | 16434500 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.47 | 19483382 |
| MESH:D001943 |
Breast Neoplasms |
|
salinomycin |
3.32 | 19682730 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,4-dinitrotoluene |
3.08 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
3.08 | 16705839 |
| MESH:D002386 |
Cataract |
|
4-amino-2,6-dinitrotoluene |
3.79 | 14694615 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
2.98 | 6135515 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.05 | 19176532 |
| MESH:D000013 |
Congenital Abnormalities |
|
4-amino-2,6-dinitrotoluene |
4.45 | 15095906 |
| MESH:D003490 |
Cyanosis |
|
2,4-dinitrotoluene |
12.32 | 18551238 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
12.32 | 18551238 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.55 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,4-dinitrotoluene |
6.77 | 21346803 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
6.77 | 18551238 21346803 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
4-amino-2,6-dinitrotoluene |
6.77 | 21346803 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.80 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.09 | 19236843 20131406 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.71 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.41 | 19772884 16221962 18467677 19176532 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.49 | 20558911 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.82 | 16306350 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,4-dinitrotoluene |
8.27 | 16705839 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
8.27 | 16705839 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
8.05 | 7678174 |
| MESH:D008113 |
Liver Neoplasms |
|
Clofibric Acid |
8.05 | 17602206 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
8.05 | 20007298 15890375 16377806 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.72 | 6135515 2876784 2876786 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
salinomycin |
3.95 | 19682730 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.92 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.25 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.19 | 16411023 |
| MESH:D009336 |
Necrosis |
|
2,4-dinitrotoluene |
11.94 | 18551238 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
11.94 | 18551238 7678174 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.08 | 17405874 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.87 | 20558911 |
| MESH:D009784 |
Occupational Diseases |
|
2,4-dinitrotoluene |
16.99 | 12819281 16049721 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
16.99 | 16049721 |
| MESH:D009784 |
Occupational Diseases |
|
4-amino-2,6-dinitrotoluene |
16.99 | 14694615 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.52 | 19058328 |
| MESH:D012640 |
Seizures |
|
2,4-dinitrotoluene |
6.56 | 18551238 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
6.56 | 18551238 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,4-dinitrotoluene |
5.36 | 16049721 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
5.36 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,4-dinitrotoluene |
13.58 | 10091137 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
13.58 | 10091137 |
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