AutismKB 2.0

Annotation Detail for PPP1R13B


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Basic Information Top
Gene Symbol:PPP1R13B ( ASPP1,KIAA0771,p53BP2-like,p85 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 13B
Band: 14q32.33
Quick LinksEntrez ID:23368; OMIM: 606455; Uniprot ID:ASPP1_HUMAN; ENSEMBL ID: ENSG00000088808; HGNC ID: 14950
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PPP1R13B mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in increased expression of PPP1R13B mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PPP1R13B mRNAaffects expression 17555576
C041786 palm oil palm oil results in increased expression of PPP1R13B mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PPP1R13B mRNAaffects binding|decreases expression|increases activity 19710929
D020849 Raloxifene Raloxifene results in decreased expression of PPP1R13B mRNAdecreases expression 16202921
D013629 Tamoxifen Tamoxifen affects the expression of PPP1R13B mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000419 Albuminuria Raloxifene 4.9217451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001161 Arteriosclerosis Dietary Fats 11.1315238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 11.1311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001930 Brain Injuries Raloxifene 4.8316580743
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Raloxifene 1.9617049068 16912660 15775269 15758505 17893378 17242785 17952589 16837676 15572757 17261762 17595753 17440819
MESH:D001943 Breast Neoplasms Tamoxifen 1.9617242785 20390343 19410462 18815881 16818667 11161223 18984771 17893378 19244106 19221464 18351453 18855134 20065188 19189212 19487384 19115204 18997820 20859285 20005174 19084267 19103187 19200415 18821012 19011961 19066611 18629630 19288272 20135344 19155303 19189210 17440819 19142967 19059307 21152245 21138602 15565566 17049068 15668708 19289846 17261762 18425577 16202921 16873071 20544844 16273361
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.953084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 2.9516924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.4017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.4017572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6315775269
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4216919318 15861022 16105132 17333356 11677210 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D003072 Cognition Disorders Raloxifene 4.9815800139
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4117474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003928 Diabetic Nephropathies Raloxifene 9.8717308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.8719279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6516109766 12958197 19164858 17522070 16177239 11529661 16081117 12705907 19420014 16781746 11743745 11421492 16393943 19739265 19085960 15968718 12594235 14725611 16485898 19416960 12392966 10663392 18713872 18071297 11739529 11461765 16227642 17906064 10774834 12153990 19370779 12540782 15619225 11287661 14986274 14550746 17562736 10915739 11834606 2444490 19923254
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:D004487 Edema pirinixic acid 7.8412083418
MESH:D004487 Edema Raloxifene 7.8415860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 17.3612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 17.3615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.3619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2117893378 20544844 16202921 19155303
MESH:D005234 Fatty Liver Dietary Fats 27.9419004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.9415345470
MESH:D005234 Fatty Liver pirinixic acid 27.9420131406 19236843
MESH:D005234 Fatty Liver Raloxifene 27.9417473493
MESH:D005234 Fatty Liver Tamoxifen 27.9419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Dietary Fats 3.8818296743
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006331 Heart Diseases Raloxifene 3.7211110106
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3518467677 16221962 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D006973 Hypertension Raloxifene 2.9515787275 17577099
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Dietary Fats 5.5320412841
MESH:D007249 Inflammation Tamoxifen 5.5319457130
MESH:D007333 Insulin Resistance Dietary Fats 7.8211836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2718625569
MESH:D007889 Leiomyoma Raloxifene 4.8016973256
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0118296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3918564211
MESH:D008107 Liver Diseases Acetaminophen 1.6811587558 19460945 16611625 19784758 16610002 19014921 12969438 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 4.7316377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 4.7316684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7911731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0015863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6316497877
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009232 Myxoma Raloxifene 6.0016343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19189210 19200415
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity Dietary Fats 4.6220132043 18674790 11836018 21332399 20518802 17217161 19632207 18457598 16723640
MESH:D009765 Obesity pirinixic acid 4.6220558911
MESH:D010024 Osteoporosis Raloxifene 3.5517882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5317823083 15579764 15758505 17893378
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3016220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D011693 Purpura Raloxifene 6.0015770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D020521 Stroke Raloxifene 4.0416837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013978 Tibial Fractures Raloxifene 5.6519048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5417572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5417572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054556 Venous Thromboembolism Raloxifene 5.6516837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0016343187
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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