AutismKB 2.0

Annotation Detail for PUM2


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Basic Information Top
Gene Symbol:PUM2 ( FLJ36528,KIAA0235,MGC138251,MGC138253,PUMH2,PUML2 )
Gene Full Name: pumilio homolog 2 (Drosophila)
Band: 2p24.1
Quick LinksEntrez ID:23369; OMIM: 607205; Uniprot ID:PUM2_HUMAN; ENSEMBL ID: ENSG00000055917; HGNC ID: 14958
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PUM2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PUM2 mRNAincreases expression 18648102
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PUM2 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PUM2 mRNAdecreases expression 15336504
D004317 Doxorubicin Doxorubicin results in increased expression of PUM2 mRNAincreases expression 17888722
D007657 Ketone Bodies Ketone Bodies results in increased expression of PUM2 mRNAincreases expression 16807920
D002762 Cholecalciferol Cholecalciferol results in increased expression of PUM2 mRNAincreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Doxorubicin 2.6217418594
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D000419 Albuminuria Doxorubicin 4.8721441931
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.3916142846
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.1414601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.0717150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.5916096432 16322301 11325840 15567936 18628466 15692762 19526202 16264153 17369602 16935488 16115903 18382427 15136595 15939500 17983394 17426702 15994142 15634643 15668708 18234424 16826403 15993339 18695136 16595493
MESH:D002276 Carcinoid Tumor Doxorubicin 5.2516051944
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.823581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.8218059187 17876044 16023760 16234567
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.927296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.9216201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.706189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.7017519947 16278810 16242529 17382496 16455267 15811867 17308081 16731534 16269455 16612575 16651473 15505089 15476868 16109756 17131338 16952015 18627295 17924179 17329180 17974986 16364871 15792986 17351982 17928571 17007740
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0217334414 16243910
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.267505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.359022650 19486331
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.158970840 11906362 2524372 12868966 11298694 18759878 14531868 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.696679447 9022650 18692083 11289319 7440962 18648102 9653073 9328219 16192314 6482804 1440618 18289764 8291058
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.6917416283
MESH:D004362 Drug Toxicity Doxorubicin 3.8718602426
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6217359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6018037988
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5820426865
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9819069698
MESH:D005909 Glioblastoma Doxorubicin 3.5217150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7015692506
MESH:D006331 Heart Diseases Doxorubicin 3.6717888722 16330681 16495754 16707910 16144979 18674790 12587719 17875725 14766674 16244372 16244371 16879835 18006777
MESH:D006333 Heart Failure Doxorubicin 3.5017481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1815692506
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006689 Hodgkin Disease Doxorubicin 3.6517606976 15147373 18501091
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007674 Kidney Diseases Doxorubicin 3.2016775033 15369732 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4416707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.156582329
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6016085563
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1516439617 16595196
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.601399818 6587162 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.6016842330 17085340
MESH:D008175 Lung Neoplasms Doxorubicin 2.1517418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.6516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1915458769
MESH:D008545 Melanoma Doxorubicin 2.3216827129
MESH:D008654 Mesothelioma Doxorubicin 3.1517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7815792986
MESH:D052016 Mucositis Doxorubicin 5.1917415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0415857846 19429709
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.163581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.1618259882
MESH:D009401 Nephrosis Doxorubicin 5.1316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2515640375 16889571
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009447 Neuroblastoma Doxorubicin 3.3915555623
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7812819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.786482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D012516 Osteosarcoma Doxorubicin 4.3415930896
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6017638057
MESH:D011471 Prostatic Neoplasms Cholecalciferol 3.6817024972
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.6815749863 15897917 16868541 18437689 16888761 16729912
MESH:D051437 Renal Insufficiency Doxorubicin 4.5817922066
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012509 Sarcoma Doxorubicin 4.2515625365 17203757 16767912 18313854 15675481 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1917846226
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Doxorubicin 6.3015692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.308532709
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9317203757 16767912 15625365
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.973712494 6582329 7505956 1399818 6587162
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.9716010429 17909728
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.898074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.8917653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5817678736 17638931 17334414 16364871
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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