AutismKB 2.0

Annotation Detail for TENC1


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Basic Information Top
Gene Symbol:TENC1 ( C1-TEN,C1TEN,DKFZp686D13244,FLJ16320,KIAA1075,TNS2 )
Gene Full Name: tensin like C1 domain containing phosphatase (tensin 2)
Band: 12q13.13
Quick LinksEntrez ID:23371; OMIM: 607717; Uniprot ID:TENC1_HUMAN; ENSEMBL ID: ENSG00000111077; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of TENC1 mRNAaffects expression 18343893
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TENC1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TENC1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TENC1 mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in decreased expression of TENC1 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TENC1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TENC1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of TENC1 mRNAaffects cotreatment|decreases expression 17942748
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TENC1 mRNAaffects binding|increases activity|increases expression 19710929
D012643 Selenium Selenium results in increased expression of TENC1 mRNAincreases expression 19244175
D017632 Asbestos, Serpentine Asbestos, Serpentine results in decreased expression of TENC1 mRNAdecreases expression 16251409
D013629 Tamoxifen Tamoxifen affects the expression of TENC1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TENC1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of TENC1 mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of TENC1 mRNAaffects cotreatment|decreases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of TENC1 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of TENC1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001195 Asbestosis Asbestos, Serpentine 5.7610751356
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9521152245 11161223 17440819 18984771 19084267 20065188 17261762 20544844 19011961 16818667 20859285 19142967 19288272 19189210 19059307 20005174 21138602 19066611 17049068 19103187 19487384 19244106 20390343 18855134 16873071 18351453 17242785 17893378 19410462 19115204 19200415 18815881 18629630 15565566 18821012 18425577 19189212 16273361 19155303 16202921 19221464 20135344 18997820 19289846 15668708
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.653084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6516924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.766135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7612371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 13.7019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.7015861022 16105132 17333356 11677210 17681005 17110522 16919318
MESH:D002779 Cholestasis pirinixic acid 13.7019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.138697196 15668235 16354765 12621046 15340226
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.2521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.2518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2519923254 18071297 2444490 10915739 10663392 16485898 14725611 10774834 11739529 14986274 16781746 19420014 14550746 16227642 12153990 11287661 19739265 15619225 18713872 12392966 11529661 12594235 12540782 11834606 11743745 19164858 19416960 19370779 16081117 11461765 16109766 17906064 16393943 16177239 17522070 17562736 11421492 12705907 19085960 15968718 12958197
MESH:D056486 Drug-Induced Liver Injury Selenium 12.2515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.2520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1019155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 19.4319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.4315345470
MESH:D005234 Fatty Liver pirinixic acid 19.4320131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 19.4319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 11.5411294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5411294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.5416080930
MESH:D006333 Heart Failure pirinixic acid 7.1120558911
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6119772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6116120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 18606429 8697196 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8417937319
MESH:D007248 Infertility, Male vinclozolin 6.8416467254
MESH:D007249 Inflammation Tamoxifen 5.0219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0212200463 12878042
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.2712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.278314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.2712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.3316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.3316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.3312371664
MESH:D007680 Kidney Neoplasms Tamoxifen 18.3318625569
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D008064 Lipidoses Tamoxifen 3.2115342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.0018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6519460945 12969438 12587719 16611625 11587558 19784758 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.917678174
MESH:D008113 Liver Neoplasms pirinixic acid 10.9115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 10.9116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.902876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9012151625
MESH:D008171 Lung Diseases Asbestos, Serpentine 8.0517200189
MESH:D008171 Lung Diseases Vitamin E 8.0516863852
MESH:D008175 Lung Neoplasms Asbestos, Serpentine 4.9711198217
MESH:D008175 Lung Neoplasms Tamoxifen 4.9718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9711884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 4.9711062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.2115318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.2119196723 16827153 11731420 19196722 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.7418551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009374 Neoplasms, Experimental Asbestos, Serpentine 4.9511704859
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319200415 19196722 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.1412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D010995 Pleural Diseases Asbestos, Serpentine 5.8010923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8811896295 11399792 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.8819015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2315067354
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2315084515
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Serpentine 3.8618569384 15511213
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0518551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0116709447
MESH:D013088 Spermatocele Tamoxifen 12.0116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.4616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.4616049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.468653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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