Annotation Detail for SRGAP2
Basic Information Top
| Gene Symbol: | SRGAP2 ( ARHGAP34,FNBP2,KIAA0456,SRGAP3 ) |
|---|---|
| Gene Full Name: | SLIT-ROBO Rho GTPase activating protein 2 |
| Band: | 1q32.1 |
| Quick Links | Entrez ID:23380; OMIM: 606524; Uniprot ID:FNBP2_HUMAN; ENSEMBL ID: ENSG00000163486; HGNC ID: 19751 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Diseases/Disorders| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D016718 | Arachidonic Acid | Arachidonic Acid results in decreased expression of SRGAP2 mRNA | decreases expression | 16704987 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of SRGAP2 mRNA | decreases expression | 20064835 |
| D002117 | Calcitriol | Calcitriol results in increased expression of SRGAP2 mRNA | increases expression | 16002434 |
| D012402 | Rotenone | Rotenone results in increased expression of SRGAP2 mRNA | increases expression | 19013527 |
| C034613 | triacsin C | triacsin C results in decreased expression of SRGAP2 mRNA | decreases expression | 16704987 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 2.05 | 20464547 20127859 | |
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 2.84 | 6695378 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 4.56 | 19183758 | |
| MESH:D001321 | Autistic Disorder | Arachidonic Acid | 3.01 | 18582451 | |
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 2.19 | 17474063 20146248 | |
| MESH:D001943 | Breast Neoplasms | Calcitriol | 2.19 | 11237771 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 4.97 | 20419170 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Calcitriol | 4.97 | 11237771 | |
| MESH:D004487 | Edema | Arachidonic Acid | 4.40 | 9831321 15177302 9599246 7990266 11698051 16716910 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Calcitriol | 4.37 | 15138306 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 2.07 | 16530937 | |
| MESH:D005334 | Fever | Arachidonic Acid | 5.00 | 11852909 | |
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 2.82 | 20471113 | |
| MESH:D007249 | Inflammation | Arachidonic Acid | 3.67 | 15177302 17371808 9831321 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 2.14 | 21137059 20195826 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 1.57 | 20869020 18569708 20135361 20464547 6695378 17053015 18816296 18520028 20064080 | |
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 3.46 | 16381670 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 2.31 | 11141357 | |
| MESH:D009410 | Nerve Degeneration | Rotenone | 4.15 | 18619942 17356569 15790535 | |
| MESH:D010300 | Parkinson Disease | Rotenone | 3.08 | 16412576 15451049 11535288 19114014 19232380 11445065 18191903 16140633 18619942 | |
| MESH:D020734 | Parkinsonian Disorders | Rotenone | 4.42 | 15927086 18197244 15795934 15574749 | |
| MESH:D011470 | Prostatic Hyperplasia | Calcitriol | 5.32 | 15572423 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 3.20 | 17292933 | |
| MESH:D011471 | Prostatic Neoplasms | Calcitriol | 3.20 | 16289102 18247401 12479363 15754350 16644109 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 2.51 | 19755658 10029692 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 1.56 | 2093021 20155912 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 2.29 | 17053015 |
| Pathway ID | Pathway Name |
|---|---|
| REACT:18266 | Axon guidance |
| KEGG:04360 | Axon guidance |
| REACT:11044 | Signaling by Rho GTPases |