AutismKB 2.0

Annotation Detail for AHCYL2


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Basic Information Top
Gene Symbol:AHCYL2 ( ADOHCYASE3,FLJ21719,KIAA0828 )
Gene Full Name: adenosylhomocysteinase-like 2
Band: 7q32.1
Quick LinksEntrez ID:23382; OMIM: NA; Uniprot ID:SAHH3_HUMAN; ENSEMBL ID: ENSG00000158467; HGNC ID: 22204
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
METHIONINE-DEG1-PWYmethionine degradation I (to homocysteine)
PWY-5328superpathway of methionine degradation
PWY-6292cysteine biosynthesis III (mammalia)
Pathway IDPathway Name
hsa00450Selenoamino acid metabolism
hsa01100Metabolic pathways
hsa00270Cysteine and methionine metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of AHCYL2 mRNAincreases expression 16788091
D014212 Tretinoin Tretinoin results in increased expression of AHCYL2 mRNAincreases expression 16788091
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000505 Alopecia Tretinoin 4.0215955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.3516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3416292516
MESH:D001249 Asthma Tretinoin 2.4516456186
MESH:D001471 Barrett Esophagus Tretinoin 5.0816935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.1616197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2216873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.4816813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 6.2316168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.921917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3916051514 16096774
MESH:D002386 Cataract Tretinoin 3.3417460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.4816129372
MESH:D002822 Choriocarcinoma Tretinoin 6.2316461808
MESH:D002972 Cleft Palate Tretinoin 2.839407595
MESH:D003092 Colitis Tretinoin 4.4717035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839125849 8800419 17551590 9142499 10589399 9211117 9664655 16925845 14991402 9224671
MESH:D004489 Edema, Cardiac Tretinoin 5.5418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.4016569247
MESH:D005124 Eye Abnormalities Tretinoin 3.949664655 16938888
MESH:D005355 Fibrosis Tretinoin 4.2717994277
MESH:D005909 Glioblastoma Tretinoin 3.3017312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 6.2316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.1114991402 9664655
MESH:D006930 Hyperalgesia Tretinoin 3.6216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.3316778211
MESH:D007410 Intestinal Diseases Tretinoin 4.5317994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.4517551590 15992940
MESH:D007938 Leukemia Tretinoin 2.9717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.2516932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1317596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.4519225113 19642359 16823087 16331271 16935935 17217047 12679006 16766008 17294898 15748426 17649720 17712046 17361223 17368321 19029980 16140955 17301526 16788101 16891316 19075265 17506722 9834237 17339181 19035177 17107899
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.659224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008527 Medulloblastoma Tretinoin 2.9317453147
MESH:D008545 Melanoma Tretinoin 1.9916752155
MESH:D008591 Meningomyelocele Tretinoin 5.1916940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.3217596541
MESH:D009369 Neoplasms Tretinoin 2.6016946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.459125849
MESH:D009436 Neural Tube Defects Tretinoin 3.359142499
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4616936753
MESH:D010146 Pain Tretinoin 3.3316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5915976015
MESH:D011507 Proteinuria Tretinoin 4.2116636307
MESH:D011625 Pterygium Tretinoin 5.6816723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.7116283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7916467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.4016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.2916051514
MESH:D014376 Tuberculosis Tretinoin 3.5016040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.1816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.6816752155
MESH:D014820 Vitiligo Tretinoin 4.7316761959
MESH:D009396 Wilms Tumor Tretinoin 4.4416287080
Pathway ID Pathway Name
KEGG:00270 Cysteine and methionine metabolism
KEGG:01100 Metabolic pathways
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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