AutismKB 2.0

Annotation Detail for NUDCD3


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Basic Information Top
Gene Symbol:NUDCD3 ( KIAA1068,NudCL )
Gene Full Name: NudC domain containing 3
Band: 7p13
Quick LinksEntrez ID:23386; OMIM: 610296; Uniprot ID:NUDC3_HUMAN; ENSEMBL ID: ENSG00000015676; HGNC ID: 22208
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of NUDCD3 mRNAincreases expression 18648102
D015525 Fatty Acids, Omega-3 Fatty Acids, Omega-3 results in decreased expression of NUDCD3 mRNAdecreases expression 16823509
D043371 Fatty Acids, Omega-6 Fatty Acids, Omega-6 results in increased expression of NUDCD3 mRNAincreases expression 16823509
D010634 Phenobarbital Phenobarbital results in decreased methylation of NUDCD3 promoterdecreases methylation 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of NUDCD3 mRNAincreases expression 19270015
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.076195326
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.6017620307
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-3 10.1218448859
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-6 10.1218448859
MESH:D001321 Autistic Disorder Fatty Acids, Omega-3 3.4516920077
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.7411289319 1440618
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.163581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.1617173139 20007298 20935162 6705139 1701930
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.027505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.814080065
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.449022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.3511906362 18759878 11298694 8156756 8970840 12868966 2524372 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.952952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0411289319 9022650 6482804 16192314 18289764 6679447 18692083 9653073 18648102 7440962 1440618 8291058 9328219
MESH:D004421 Dystonia Phenobarbital 4.471851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.673659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.593922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.916401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.653659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.183581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006529 Hepatomegaly Phenobarbital 4.0416109766
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D007249 Inflammation Fatty Acids, Omega-3 4.1417296493
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.749022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.316582329
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0821047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.429327722 15034207
MESH:D008107 Liver Diseases Phenobarbital 2.2419363144
MESH:D008113 Liver Neoplasms Phenobarbital 2.4215975961 19812893 21047994 19073162 8742319 19482888
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.713712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.716150874 1399818 18308698 17172636 2563599
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.1117484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.593581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.156679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.814026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010018 Osteomalacia Phenobarbital 5.0017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6016965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D011230 Precancerous Conditions Phenobarbital 3.992563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.2212752131
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D012640 Seizures Phenobarbital 2.9511442880 16876388 4039156 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.456407741
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.183712494 6587162 6582329 1399818 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.181399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.408074119
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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