AutismKB 2.0

Annotation Detail for MED13L


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Basic Information Top
Gene Symbol:MED13L ( DKFZp781D0112,FLJ21627,KIAA1025,PROSIT240,THRAP2,TRAP240L )
Gene Full Name: mediator complex subunit 13-like
Band: 12q24.21
Quick LinksEntrez ID:23389; OMIM: 608771; Uniprot ID:MD13L_HUMAN; ENSEMBL ID: ENSG00000123066; HGNC ID: 22962
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Transposition of the great arteries, dextro-looped 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MED13L mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MED13L mRNAdecreases expression 19150397
D003520 Cyclophosphamide MED13L mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D004317 Doxorubicin MED13L mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D005472 Fluorouracil MED13L mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D017239 Paclitaxel MED13L mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D012643 Selenium Selenium results in decreased expression of MED13L mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MED13L mRNAdecreases expression 17337447
C025643 vinclozolin vinclozolin affects the expression of MED13L mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.4120127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 7.4117418594
MESH:D000230 Adenocarcinoma Fluorouracil 7.4117638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000419 Albuminuria Doxorubicin 4.7821441931
MESH:D000740 Anemia Fluorouracil 9.3317963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.3311748828
MESH:D001008 Anxiety Disorders vinclozolin 3.8019015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.8615014928
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.0214601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.7915867366
MESH:D001932 Brain Neoplasms Doxorubicin 4.0017150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.0520146248 17474063
MESH:D001943 Breast Neoplasms Cyclophosphamide 3.0517020986 17388661 16978400 18234424 15136595 11325840 15093573 18323546 12006526
MESH:D001943 Breast Neoplasms Doxorubicin 3.0516322301 15939500 15634643 18628466 16935488 15136595 15668708 16096432 17983394 17369602 16264153 19526202 18695136 15993339 16826403 16115903 15567936 18382427 11325840 18234424 17426702 15692762 15994142 16595493
MESH:D001943 Breast Neoplasms Fluorouracil 3.0515136595 19217205 16557594 16595493 18608205 18357371 16110121
MESH:D001943 Breast Neoplasms Paclitaxel 3.0516115903 16273361 18223236 16244791 18234424 15136595 18323546 11325840
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0520435547
MESH:D002276 Carcinoid Tumor Doxorubicin 13.4416051944
MESH:D002276 Carcinoid Tumor Fluorouracil 13.4416051944
MESH:D002277 Carcinoma Fluorouracil 8.7417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 6.9119701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.9118059187 16023760 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.9118930000 16332177 17971768 17045692 16799960 17088986
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 6.9116313753
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.1716152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 11.4016201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 11.4016201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 11.4018695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8820419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.886189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.8816757204 17066447 18986760 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.6616952015 16731534 16612575 16269455 16242529 18627295 17974986 15476868 17382496 16109756 16278810 17519947 15792986 17007740 16455267 15505089 17924179 17308081 15811867 17131338 17928571 17329180 16651473 16364871 17351982
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0017334414 16243910
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 15340226 8697196 12621046 15668235
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2618772588 16510598 16340194 15001691 17287894 17725105 17169374 17172411 17018589 17016597
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.6418259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.6417594712 17401013 17094418 16391804 14970324 17695437 18288408 17454858 15289873 15148649 17255274 16303861 17016601 18802399 18949393 18509181 16331619 18383874 16524972 16282729 18448328 20501625
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.6418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.5814966744
MESH:D003556 Cystitis Cyclophosphamide 5.3017010015 18093676 16651033 16614059 15276878 15643279 11948286 12388444 17979934 18483878 12161096 18433785 18710439 12913760 16989017 10498854 10700343 18372110 16413132 18295254
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.2411751995 15331540 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2718772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.5717416283
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5720420201
MESH:D004362 Drug Toxicity Doxorubicin 8.6118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.6111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5817359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.4718037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.4711006010
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.8120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.8116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.8115173087 16481741 16337965 17638652 16785472
MESH:D004938 Esophageal Neoplasms Paclitaxel 10.8116481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.8719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6216417039
MESH:D005909 Glioblastoma Doxorubicin 3.4717150277
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.8011389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.2916376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.3615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.3615162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.6216244371 18006777 16144979 16879835 16707910 16495754 18674790 16244372 16330681 17888722 17875725 12587719 14766674
MESH:D006333 Heart Failure Doxorubicin 7.6417481944
MESH:D006333 Heart Failure Selenium 7.6417162251
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1115692506
MESH:D006467 Hemophilia A Cyclophosphamide 5.5511918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.8514986274
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 12621046 16120746
MESH:D006689 Hodgkin Disease Cyclophosphamide 8.3217606976 16135485
MESH:D006689 Hodgkin Disease Doxorubicin 8.3217606976 15147373 18501091
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3618606429 16959395 16354765 8697196 15340226
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D007154 Immune System Diseases Cyclophosphamide 5.6516076520
MESH:D007248 Infertility, Male Cyclophosphamide 7.527193160 16517039
MESH:D007248 Infertility, Male vinclozolin 7.5216467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512878042 12200463
MESH:D007251 Influenza, Human Selenium 4.5116624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Doxorubicin 3.1615699352 16775033 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 10.6816707910
MESH:D007676 Kidney Failure, Chronic Selenium 10.6816518626
MESH:D007680 Kidney Neoplasms Fluorouracil 3.4816985049
MESH:D007938 Leukemia Cyclophosphamide 3.5810602166
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.4716085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5718172266 18587576 17008537 17802794 17658394 17296974
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.2410373061
MESH:D007970 Leukopenia Cyclophosphamide 5.2510052129 11830472
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0216417039
MESH:D008080 Liposarcoma Paclitaxel 5.0417353645
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.4816595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4812878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8021137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 7.8017045692 18383874 16603448 15113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8016984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.3117085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3112151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.026695378 20464547 20869020 18569708 20064080 18816296 17053015 18520028 20135361
MESH:D008175 Lung Neoplasms Doxorubicin 5.0217418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 5.0215246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0219555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D008223 Lymphoma Cyclophosphamide 8.3612854902
MESH:D008223 Lymphoma Doxorubicin 8.3616098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.8216675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 15.7111911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 15.7117654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 15.7114749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.8315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.6115458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6115318939
MESH:D008545 Melanoma Doxorubicin 3.7716827129
MESH:D008545 Melanoma Paclitaxel 3.7716342250 12025231 12040289
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.0616388313
MESH:D008654 Mesothelioma Doxorubicin 6.5217638057
MESH:D008654 Mesothelioma Selenium 6.5215107826
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7015792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.0616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.0616757204 18986760
MESH:D052016 Mucositis Doxorubicin 5.0817415656
MESH:D009101 Multiple Myeloma Paclitaxel 3.8314749477
MESH:D009203 Myocardial Infarction Doxorubicin 3.0219429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.3718259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.3715867366
MESH:D009369 Neoplasms Benzo(a)pyrene 8.9211141357
MESH:D009369 Neoplasms Cyclophosphamide 8.9218854779
MESH:D009369 Neoplasms Fluorouracil 8.9216928823 18239605 18600527
MESH:D009401 Nephrosis Doxorubicin 5.0316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1815640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009447 Neuroblastoma Cyclophosphamide 7.538761367 16115947 15176712
MESH:D009447 Neuroblastoma Doxorubicin 7.5315555623
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.178761367 12837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009503 Neutropenia Cyclophosphamide 4.548291058
MESH:D009845 Oligospermia Cyclophosphamide 5.0016517039
MESH:D010014 Osteolysis Paclitaxel 5.2615867366
MESH:D012516 Osteosarcoma Doxorubicin 4.2815930896
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0411161223
MESH:D010146 Pain Cyclophosphamide 3.7912161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.8211332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.8216500647 16929163 19003803 15113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.4717983394
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.4717638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.9121297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4611399792 11118676 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.4619015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.2218220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 1.8817136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8816868541 15897917 16888761 18437689 15749863 16729912
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8817136230 16356831 16729912 17172428
MESH:D011472 Prostatitis vinclozolin 5.2218629315
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3516636934
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1918722050 15538739 16160472 18286688
MESH:D051437 Renal Insufficiency Doxorubicin 4.4817922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012509 Sarcoma Doxorubicin 4.1817710206 15625365 17203757 16767912 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.0817846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.0416636934
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.9410029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 9.9415692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.9416192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.8315625365 17203757 16767912
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.8016517039
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.5420155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5415786421 19015929 19084572 17522103 17172411 18396642 16951190 16424979 18567086 17498489
MESH:D013274 Stomach Neoplasms Paclitaxel 3.5418506536 18396642
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.3412837982
MESH:D024801 Tauopathies Paclitaxel 5.1016930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5216010429 17909728
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
OMIM:608808 TRANSPOSITION OF THE GREAT ARTERIES, DEXTRO-LOOPED 1 marker/mechanism
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8617053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 8.8614692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.8617653716
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4817678736 16364871 17334414 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:27166 Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162395233
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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