AutismKB 2.0

Annotation Detail for FNTA


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Basic Information Top
Gene Symbol:FNTA ( FPTA,MGC99680,PGGT1A,PTAR2 )
Gene Full Name: farnesyltransferase, CAAX box, alpha
Band: 8p11.21
Quick LinksEntrez ID:2339; OMIM: 134635; Uniprot ID:FNTA_HUMAN; ENSEMBL ID: ENSG00000168522; HGNC ID: 3782
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Apoptosis
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Pathway IDPathway Name
500270Apoptotic cleavage of cellular proteins
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FNTA mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of FNTA mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FNTA mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FNTA mRNAaffects expression 16483693
D001194 Asbestos Asbestos affects the expression of FNTA mRNAaffects expression 17297452
D002330 Carmustine Carmustine results in decreased expression of FNTA mRNAdecreases expression 15980968
D002330 Carmustine Carmustine results in increased expression of FNTA mRNAincreases expression 15980968
D016572 Cyclosporine Cyclosporine results in increased expression of FNTA mRNAincreases expression 20106945
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of FNTA mRNAaffects cotreatment|increases expression 16996129
D009151 Mustard Gas Mustard Gas affects the expression of FNTA mRNAaffects expression 15651846
C032208 perilla alcohol [Vitamin A co-treated with perilla alcohol] results in decreased expression of FNTA proteinaffects cotreatment|decreases expression 15959631
C111350 Sch 59228 Sch 59228 results in decreased activity of FNTA proteindecreases activity 9923541
D018038 Sodium Selenite Sodium Selenite results in increased expression of FNTA mRNAincreases expression 18175754
D014635 Valproic Acid Valproic Acid results in decreased expression of FNTA mRNAdecreases expression 19101580
D014801 Vitamin A [Vitamin A co-treated with perilla alcohol] results in decreased expression of FNTA proteinaffects cotreatment|decreases expression 15959631
D014812 Vitamin K Vitamin K affects the expression of FNTA mRNAaffects expression 16844298
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of FNTA mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.548875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 10.4719490988
MESH:D000015 Abnormalities, Multiple Vitamin A 10.4710992263
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D058186 Acute Kidney Injury zoledronic acid 4.4919715164
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.5320200999
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D000740 Anemia Vitamin A 4.5516960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.8216960172
MESH:D001008 Anxiety Disorders Valproic Acid 3.5917497229
MESH:D001249 Asthma Mustard Gas 5.3810378619
MESH:D001249 Asthma Vitamin A 5.3816732791
MESH:D050197 Atherosclerosis Asbestos 4.2318795166
MESH:D001321 Autistic Disorder Valproic Acid 2.0017688650 18775368 18316065 16609825 17507914 18940202 18558336 15238991 20603192 19460635 18985861 18177632 19232924 18396377 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 3.0917594078 20046352
MESH:D001768 Blister Mustard Gas 5.2119167455
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.428888407
MESH:D001859 Bone Neoplasms zoledronic acid 4.9917312309 16778634 11697798 15867366 16121404 19442620
MESH:D001862 Bone Resorption zoledronic acid 4.7316769263 11869084 18496637 15845617 8053405 18404659
MESH:D001932 Brain Neoplasms Carmustine 4.4116187019
MESH:D001943 Breast Neoplasms zoledronic acid 3.3118695136 16096432
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0417687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 5.6517377406 17426644
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8816705839
MESH:D006528 Carcinoma, Hepatocellular Vitamin K 4.8816328049
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.5519233551
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 3.8618507039
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.646135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.6412371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D015362 Child Nutrition Disorders Vitamin A 5.5416153327
MESH:D002779 Cholestasis Cyclosporine 8.3719486331
MESH:D002779 Cholestasis Vitamin A 8.3716175620
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D002972 Cleft Palate Vitamin A 3.6916054864
MESH:D003110 Colonic Neoplasms Vitamin A 3.0417219422 16267017
MESH:D003327 Coronary Disease fluvastatin 4.8316142594
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.068888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin A 3.0610992263
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8016285004
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.5116506275
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.0721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.0715131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.071733752 19641884
MESH:D015352 Dry Eye Syndromes Vitamin A 5.8516146918
MESH:D004421 Dystonia Valproic Acid 4.081851702
MESH:C538011 Eales disease Vitamin A 5.689068938
MESH:D004480 Ectromelia Vitamin A 5.8816054864
MESH:D004487 Edema Mustard Gas 3.3411428631 9260866 11402378 11428647
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.1917275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.983922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9520417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.616426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.113659116
MESH:D004890 Erythema Mustard Gas 5.219357497
MESH:D005234 Fatty Liver Cyclosporine 7.8519224547
MESH:D005234 Fatty Liver Valproic Acid 7.8514986274 19224547
MESH:D005264 Femoral Fractures zoledronic acid 5.8816234978
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.178888407 18558336
MESH:D005327 Fetal Resorption Vitamin A 5.4316054864
MESH:D005355 Fibrosis Cyclosporine 3.1812168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005909 Glioblastoma Carmustine 3.9416187019
MESH:D006330 Heart Defects, Congenital Vitamin A 3.9216080930 10992263
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.6317436238 16877224 16490937 16863852 16292552 15707848
MESH:D015658 HIV Infections Vitamin A 3.8316960176
MESH:D006679 HIV Seropositivity Vitamin A 5.6517209195
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006930 Hyperalgesia zoledronic acid 4.2716769263
MESH:D006934 Hypercalcemia zoledronic acid 5.0719622757 18089816
MESH:D006973 Hypertension Cyclosporine 2.1110903974
MESH:D006986 Hypervitaminosis A Vitamin A 6.2316054864
MESH:D006996 Hypocalcemia zoledronic acid 6.2612669777
MESH:D007249 Inflammation Mustard Gas 2.8016001271 11428620 11428631 9260866 11428647 8975870 9357497 17524151 11402378
MESH:D007333 Insulin Resistance Sodium Selenite 3.2914714311
MESH:D019586 Intracranial Hypertension Vitamin A 5.8815955940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Cyclosporine 2.358314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.5116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.5116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.5112371664
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.8018089816
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1516294345 17596541
MESH:D017880 Limb Deformities, Congenital Vitamin A 4.3416054864
MESH:D008103 Liver Cirrhosis Vitamin A 3.8916256175
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 2.8116248980
MESH:D008107 Liver Diseases Vitamin A 3.1616175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 5.2016762690
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.167678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.372876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 6.3717113696
MESH:D008171 Lung Diseases Mustard Gas 7.9418702808 18161513
MESH:D008171 Lung Diseases Vitamin A 7.9416863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3217228818
MESH:D008175 Lung Neoplasms Asbestos 3.1212111688
MESH:D008175 Lung Neoplasms Mustard Gas 3.128781369 3148597
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 3.7417312309
MESH:D008545 Melanoma Carmustine 2.8712393984
MESH:D008654 Mesothelioma Asbestos 7.0516919927 16319530 18310086 18709470 16564556
MESH:D008654 Mesothelioma zoledronic acid 7.0516675582
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2118803445 18765137
MESH:D009101 Multiple Myeloma fluvastatin 12.6716996129
MESH:D009101 Multiple Myeloma Vitamin A 12.6716374440
MESH:D009101 Multiple Myeloma zoledronic acid 12.6719621390 18089719 16996129
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1717596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.5218551238 7678174
MESH:D009362 Neoplasm Metastasis zoledronic acid 3.6515867366 17312309 19139120
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009436 Neural Tube Defects Valproic Acid 7.748888407 16359493
MESH:D009436 Neural Tube Defects Vitamin A 7.7417400914
MESH:D009503 Neutropenia Mustard Gas 4.0016761898 7688884
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9816049721
MESH:D010014 Osteolysis zoledronic acid 5.4215867366
MESH:D010024 Osteoporosis zoledronic acid 4.0517882678
MESH:D010146 Pain zoledronic acid 3.9616475674
MESH:D011041 Poisoning Mustard Gas 3.8315727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.8820603192
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.6918760546
MESH:D011471 Prostatic Neoplasms zoledronic acid 3.6912438248 19103299
MESH:D011537 Pruritus Mustard Gas 4.1418058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.6011422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9417720292 17266442 17620002 17894541 10334151
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.8516877224
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2119155313
MESH:D012512 Sarcoma, Ewing's zoledronic acid 4.9716121404
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 9.9318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.9318551238
MESH:D012640 Seizures Valproic Acid 9.9315475178 14763951 16876388 1511512 11738929 3137016 17978042 11044598
MESH:D012871 Skin Diseases Mustard Gas 5.3912880345 16961503 15451306
MESH:D012871 Skin Diseases Vitamin A 5.3918709164
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8019490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6012833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0516049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D014802 Vitamin A Deficiency Vitamin A 5.3116146918 16175781 16960172
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
REACT:578 Apoptosis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB06953 - 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE
DB07216 - (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE
DB07227 - 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE
DB07752 - FARNESYL
DB07771 - [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
DB07780 - FARNESYL DIPHOSPHATE
DB07841 - GERANYLGERANYL DIPHOSPHATE
DB07895 - ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID
DB08180 - 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
DB08674 - (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE
DB08676 - (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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