AutismKB 2.0

Annotation Detail for ADNP


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Basic Information Top
Gene Symbol:ADNP ( ADNP1,KIAA0784 )
Gene Full Name: activity-dependent neuroprotector homeobox
Band: 20q13.13
Quick LinksEntrez ID:23394; OMIM: 611386; Uniprot ID:ADNP_HUMAN; ENSEMBL ID: ENSG00000101126; HGNC ID: 15766
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADNP mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ADNP mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ADNP mRNAdecreases expression 19150397
D007213 Indomethacin Indomethacin results in decreased expression of ADNP mRNAdecreases expression 16984733
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ADNP mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of ADNP mRNAincreases expression 12832660
D012402 Rotenone Rotenone results in decreased expression of ADNP mRNAdecreases expression 19013527
D014501 Uranium Uranium affects the expression of ADNP mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of ADNP mRNAaffects expression 15672453
C025643 vinclozolin vinclozolin affects the expression of ADNP mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Indomethacin 2.8316537180
MESH:D000236 Adenoma Indomethacin 3.5811497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D016301 Alveolar Bone Loss Indomethacin 5.7517225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7417627676 15579461
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001014 Aortic Aneurysm Indomethacin 5.1310231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.1810388637
MESH:D018771 Arthralgia Indomethacin 5.552160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8711248219
MESH:D001477 Bartter Syndrome Indomethacin 5.2910684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001929 Brain Edema Indomethacin 5.4011481608
MESH:D002545 Brain Ischemia Indomethacin 4.7512524144
MESH:D001943 Breast Neoplasms Indomethacin 2.8017401462
MESH:D002056 Burns Indomethacin 5.0110459503
MESH:D002100 Cachexia Indomethacin 5.3415625704 16537180 15141370 11239499
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 2.4716391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.0611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.6911352223 14736730 18791128
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4717341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.9012636206 15482327
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8820889678
MESH:D002764 Cholecystitis Indomethacin 5.5511181007
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003110 Colonic Neoplasms Indomethacin 2.6215625704 15786552 15637740 15963497 11260862 15936596
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3617054584 12606626 18059344 11197048
MESH:D018352 Coronavirus Infections Indomethacin 6.0917302372
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003967 Diarrhea Indomethacin 4.077907874 7237001
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.4916133044 18043480 17190690 18446180 16326151 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 4.4211595415 17351913 16699067 11991626 11535926 17045617 17329845 17202747 17151854 10671773 11595431
MESH:D004487 Edema Indomethacin 7.767907874 10653021 16100529 7990266 19703484 8273558 8985016
MESH:D004487 Edema pirinixic acid 7.7612083418
MESH:D004715 Endometriosis Indomethacin 4.3715652904
MESH:D019446 Endotoxemia Indomethacin 4.8418509659
MESH:D004751 Enteritis Indomethacin 5.1217763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.2917980183
MESH:D004802 Eosinophilia Indomethacin 4.3611298111
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.8220426865
MESH:D004938 Esophageal Neoplasms Indomethacin 4.8211005569
MESH:D005234 Fatty Liver pirinixic acid 3.0120131406 19236843
MESH:D005334 Fever Indomethacin 4.3510431976 17627676 11852909
MESH:D005354 Fibrosarcoma Indomethacin 5.2310962813
MESH:D005355 Fibrosis Indomethacin 4.3817994277
MESH:D005499 Folliculitis Indomethacin 5.5511298111
MESH:D005756 Gastritis Indomethacin 5.1215046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005909 Glioblastoma Indomethacin 3.7112870263
MESH:D005910 Glioma Indomethacin 3.3016487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.4811849393
MESH:D006073 Gout Indomethacin 5.6911248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.9015482327
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.8115633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.9615135802
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 18467677 19772884 19176532
MESH:D006930 Hyperalgesia Indomethacin 3.9612727271
MESH:D034321 Hyperamylasemia Indomethacin 6.0917883296
MESH:D006940 Hyperemia Indomethacin 5.3412524144
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Indomethacin 4.4217546600
MESH:D007077 Ileal Diseases Indomethacin 5.4018306037 10574470
MESH:D007079 Ileitis Indomethacin 5.6910651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.7516133044
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007249 Inflammation Indomethacin 3.087812673 3291741 12568917
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007410 Intestinal Diseases Indomethacin 4.6310210152 11713966 18236018 17329856 15610444 15831440 11855677 11686837 17994277
MESH:D019586 Intracranial Hypertension Indomethacin 5.7515241188
MESH:D007579 Jejunal Diseases Indomethacin 5.4018306037 16133968 10574470
MESH:D007674 Kidney Diseases Indomethacin 3.3917190690
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.1012228301 10320625 11703811
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.1015631656 10785260 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6718360721
MESH:D007964 Leukocytosis Indomethacin 5.7516537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.0917980183
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.0911479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.6118194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.6115474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.8916377806 20007298 15890375
MESH:D008175 Lung Neoplasms Indomethacin 2.3611497255 11053908 16537180
MESH:D008881 Migraine Disorders Indomethacin 3.8411903285
MESH:D009062 Mouth Neoplasms Indomethacin 4.1712636206
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis Indomethacin 3.2511239499 11053908 16537180
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.4410663608 15625704
MESH:D009410 Nerve Degeneration Rotenone 4.0618619942 17356569 15790535
MESH:D019636 Neurodegenerative Diseases Indomethacin 4.1412349958
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.556374098
MESH:D010003 Osteoarthritis Indomethacin 3.807009135
MESH:D010146 Pain Indomethacin 3.6617440234 3291741 13679232 17627676
MESH:D010149 Pain, Postoperative Indomethacin 5.0612538197 18702446
MESH:D010195 Pancreatitis Indomethacin 4.1815028970 17883296
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.0916537180
MESH:D010300 Parkinson Disease Rotenone 3.0511445065 19114014 19232380 15451049 11535288 18191903 18619942 16140633 16412576
MESH:D020734 Parkinsonian Disorders Indomethacin 10.1512349958
MESH:D020734 Parkinsonian Disorders Rotenone 10.1518197244 15574749 15795934 15927086
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.0911903285
MESH:D010437 Peptic Ulcer Indomethacin 5.4911148446
MESH:D010518 Periodontitis Indomethacin 5.2917225004
MESH:D047928 Premature Birth Indomethacin 5.4317000239
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2319015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011507 Proteinuria Indomethacin 4.4211849393
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D013272 Stomach Diseases Indomethacin 4.7510486359 16113693 10215738 18209964 15472012 10192188 17160473 17207306 15038085 18545984 16184426 16280098 17638125
MESH:D013274 Stomach Neoplasms Indomethacin 2.3615609394
MESH:D013276 Stomach Ulcer Indomethacin 3.8215138204 11595431 12077510 11595415 17627676 18087811 15255614 18209962 18431645 18237397 10750652 11145282 16397915 12467913 12500499 14567935 17135157 16934674 15104355 12498302 16150113 18181030 16755016 11729361 16252198 18299717 12787963 11523592 17977527 16169175 18193104 10423059 17657623 18726076 1323529 17654042 18543354 16631530 11906479 10878458 17895592 17918041
MESH:D013964 Thyroid Neoplasms Indomethacin 3.7614736730 11352223 18791128
MESH:D014456 Ulcer Indomethacin 5.2317380554 10574470
MESH:D014839 Vomiting Indomethacin 5.1211897121
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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