AutismKB 2.0

Annotation Detail for NCAPH


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Basic Information Top
Gene Symbol:NCAPH ( BRRN1,CAP-H,HCAP-H )
Gene Full Name: non-SMC condensin I complex, subunit H
Band: 2q11.2
Quick LinksEntrez ID:23397; OMIM: 602332; Uniprot ID:CND2_HUMAN; ENSEMBL ID: ENSG00000121152; HGNC ID: 1112
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200010Aurora B signaling
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of NCAPH mRNAdecreases expression 16514628
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NCAPH proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NCAPH mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NCAPH mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of NCAPH mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of NCAPH mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of NCAPH mRNAincreases expression 16514628
C070081 fulvestrant fulvestrant results in decreased expression of NCAPH mRNAdecreases expression 16514628
D020849 Raloxifene Raloxifene results in decreased expression of NCAPH mRNAdecreases expression 16514628
D019772 Topotecan NCAPH protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014747 Vinblastine NCAPH protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.3911473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D000419 Albuminuria Raloxifene 4.7617308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001284 Atrophy fulvestrant 5.0111514358
MESH:D001930 Brain Injuries Raloxifene 4.6516580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0217474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 2.0217018787 17261762 12948864 17289903 16675129 18497071 19861407 14630087
MESH:D001943 Breast Neoplasms fulvestrant 2.0218984771
MESH:D001943 Breast Neoplasms Raloxifene 2.0217440819 17893378 17242785 17049068 15775269 15758505 16837676 17261762 17595753 15572757 17952589 16912660
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9518705752 15673190 16192424 16227642 16050911 15700767 16011737 15721981 16097048 10355542 16124888 3786805
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7121507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7118788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7116924424
MESH:D002292 Carcinoma, Renal Cell Vinblastine 3.841485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2017572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5415775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.6912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.6918566989
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D003072 Cognition Disorders Raloxifene 4.7915800139
MESH:D015179 Colorectal Neoplasms Vinblastine 2.7618802399
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2917474826
MESH:D003928 Diabetic Nephropathies Estradiol 9.4319279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.4317308373 15920148 17451421
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0721278145 19336974 9327722 15998439 15027814 7179309 4309450 7440962 2869522 19085960 10915739 10092053 17522070 6623471 15968718 7120509 16227642 11566570 3786805 6884620 3732212 16177239
MESH:D004487 Edema Raloxifene 3.4715860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.1615845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 8.0819148513
MESH:D016889 Endometrial Neoplasms Estradiol 8.0811473722 18566989 19148513
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4616530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.0012795759 16239168 15959796 19224547 12631006 16045604 61145 17595544
MESH:D005234 Fatty Liver Cyclosporine 14.0019224547
MESH:D005234 Fatty Liver Raloxifene 14.0017473493
MESH:D005355 Fibrosis Carbon Tetrachloride 9.2618705752
MESH:D005355 Fibrosis Cyclosporine 9.2612639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006331 Heart Diseases Raloxifene 3.6311110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619110552 19900420
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D006689 Hodgkin Disease Vinblastine 4.1518180244 18501091
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006973 Hypertension Cyclosporine 5.4610903974
MESH:D006973 Hypertension Raloxifene 5.4615787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007248 Infertility, Male fulvestrant 3.8411514358
MESH:D007333 Insulin Resistance Estradiol 3.0516393666 16627594
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.1918776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.1915618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6712371664
MESH:D007680 Kidney Neoplasms Estradiol 7.6715610895
MESH:D007889 Leiomyoma Raloxifene 4.6516973256
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8817157831 11903743 11408273 16943688 17334410 17174718 21278145 16221502 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4816116963 14512876 15057751 15730626 18705752 12666154 16136751 16027843 15959796 18251166 14724832 12546737 17481882 17708605 12958196 15818738 12609069 18054572 14748882 18279442 15996030 18412020 18156304 15370692 14716833 18395914 16011737 18006644 15052691 18210741 18420326 15673190 15650968 17761835 15893842 17721639 13678700 17805973 11481614 12389079 18277467 12445418 18395095 14620537 18472094 12898905 16033810 15123356 12741479 15338365 16097048 10355542 18187930 15931870 12586293 18339082 17640975 16638106 17766677 14716496 12445421 17557913 17525996 18376398 20821823 15362042 18481824 16248980 18263696 17922224 18166357 17714472 12667390 16015684 12649538 17698563 12632512 12632514 16192424 18429990 18418968 15925388 17631135 17823541 17900296 18205269 18472332 17565644 17869086 17976157 17944888 18317297 15876570
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.4814716833 14659978
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1116246199 17285989 15830285 15720792 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8216899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.732125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7321137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7319294768
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.278603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2712014681 15583823
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4518520028 20135361 18816296 20064080 20464547 17053015 6695378 18569708 20869020
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6417203775 11807958 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008545 Melanoma Vinblastine 2.9215577320 15577323 18176117 18505091 12374674 16248763 16809738 16432458 18332650 17761969
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7715863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma Raloxifene 3.5316497877
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009232 Myxoma Raloxifene 5.7716343187
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.8111399458 16427766
MESH:D009447 Neuroblastoma Topotecan 3.9115176712
MESH:D009503 Neutropenia Vinblastine 4.7217378895
MESH:D010024 Osteoporosis Raloxifene 3.4719059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3817823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5417292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.5416740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5415731164 16536755 16220300
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011693 Purpura Raloxifene 5.7715770314
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4310029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Raloxifene 3.9316837676
MESH:D013978 Tibial Fractures Estradiol 14.4519048282
MESH:D013978 Tibial Fractures Raloxifene 14.4519048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3317053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.3317572228
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014625 Vaginal Neoplasms Vinblastine 5.2215577323
MESH:D054556 Venous Thromboembolism Raloxifene 5.4316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7716343187
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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