AutismKB 2.0

Annotation Detail for DICER1


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Basic Information Top
Gene Symbol:DICER1 ( DCR1,Dicer,HERNA,KIAA0928 )
Gene Full Name: dicer 1, ribonuclease type III
Band: 14q32.13
Quick LinksEntrez ID:23405; OMIM: 606241; Uniprot ID:DICER_HUMAN; ENSEMBL ID: ENSG00000100697; HGNC ID: 17098
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Regulatory RNA pathways
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Pathway IDPathway Name
500366MicroRNA (miRNA) Biogenesis
Related Diseases/Disorders Top
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Desease Name
Pleuropulmonary blastoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DICER1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DICER1 mRNAdecreases expression 20018196
19150397
D004958 Estradiol Estradiol results in decreased expression of DICER1 mRNAdecreases expression 20106945
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of DICER1 exonincreases mutagenesis 17156454
D005472 Fluorouracil Fluorouracil results in decreased expression of DICER1 mRNAdecreases expression 16510598
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DICER1 mRNAaffects binding|increases activity|increases expression 19710929
D020849 Raloxifene Raloxifene results in decreased expression of DICER1 mRNAdecreases expression 16497877
D012643 Selenium Selenium results in decreased expression of DICER1 mRNAdecreases expression 19244175
D014415 Tunicamycin Tunicamycin results in decreased expression of DICER1 mRNAdecreases expression 17127020
D014810 Vitamin E Vitamin E results in decreased expression of DICER1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.3111473722
MESH:D000230 Adenocarcinoma Fluorouracil 7.3117638652
MESH:D000236 Adenoma Benzo(a)pyrene 7.266695378
MESH:D000236 Adenoma Ethylnitrosourea 7.266695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000419 Albuminuria Raloxifene 4.7917451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D000740 Anemia Fluorouracil 3.8717963324 15504547 16511603
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0414991843
MESH:D001930 Brain Injuries Raloxifene 4.6916580743
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4516357521 15144691 16436596 18412241 16651633
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 2.0016675129 14630087 19861407 17289903 17261762 18497071 17018787 12948864
MESH:D001943 Breast Neoplasms Fluorouracil 2.0018357371 15136595 18608205 19217205 16557594 16110121 16595493
MESH:D001943 Breast Neoplasms Raloxifene 2.0015758505 16837676 16912660 17049068 15572757 17440819 15775269 17952589 17261762 17242785 17893378 17595753
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 3.7017121937
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1516924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.1517045692 18930000 16332177 17971768 16799960 17088986
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7917066447 16280240 18986760 16757204
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2317572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5615775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.9818566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 11.9816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.2517160924
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003072 Cognition Disorders Raloxifene 4.8315800139
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617287894 15001691 17172411 16510598 17169374 18772588 17016597 17725105 17018589 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017454858 17401013 16303861 16331619 18509181 18802399 15289873 16524972 17016601 17695437 16391804 20501625 14970324 18383874 18949393 15148649 18288408 16282729 17255274 17594712 18448328 17094418
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3117474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003928 Diabetic Nephropathies Estradiol 9.5219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.5217451421 17308373 15920148
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2115131321
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.2518357618
MESH:D004487 Edema pirinixic acid 7.4612083418
MESH:D004487 Edema Raloxifene 7.4615860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.1915845917
MESH:D016889 Endometrial Neoplasms Estradiol 3.0911473722 19148513 18566989
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.4615173087 17638652 16337965 16481741 16785472
MESH:D005234 Fatty Liver pirinixic acid 8.4220131406 19236843
MESH:D005234 Fatty Liver Raloxifene 8.4217473493
MESH:D005909 Glioblastoma Ethylnitrosourea 3.9416436596
MESH:D005910 Glioma Ethylnitrosourea 6.5516651633 18412241 16357521
MESH:D005910 Glioma Fluorouracil 6.5516145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5015162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9620471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9616080930
MESH:D006331 Heart Diseases Raloxifene 3.6511110106
MESH:D006333 Heart Failure pirinixic acid 7.2820558911
MESH:D006333 Heart Failure Selenium 7.2817162251
MESH:D006529 Hepatomegaly pirinixic acid 3.2119772884 16221962 18467677 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 10.9517088409
MESH:D019584 Hot Flashes Vitamin E 10.9514716179
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Raloxifene 2.9215787275 17577099
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007333 Insulin Resistance Estradiol 7.5516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.5516306350
MESH:D007674 Kidney Diseases Estradiol 6.4115618244
MESH:D007674 Kidney Diseases Vitamin E 6.4112488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms Estradiol 13.4315610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 13.4317379185
MESH:D007680 Kidney Neoplasms Fluorouracil 13.4316985049
MESH:D007889 Leiomyoma Raloxifene 4.6816973256
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5616169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7521137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 7.7516603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 7.7515890375 16377806 20007298
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0520064080 18569708 20135361 18816296 18520028 20464547 6695378 20869020 17053015
MESH:D008175 Lung Neoplasms Ethylnitrosourea 5.0517703301 16019985 6695378 16271038
MESH:D008175 Lung Neoplasms Fluorouracil 5.0515246190
MESH:D008175 Lung Neoplasms Vitamin E 5.0511062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008223 Lymphoma Ethylnitrosourea 4.0615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.2615375218
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.7011807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 10.7010767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.7015318939
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008579 Meningioma Ethylnitrosourea 6.2517943659
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8215863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.9716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.9716757204 18986760
MESH:D009101 Multiple Myeloma Raloxifene 3.5616497877
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6916411023
MESH:D009232 Myxoma Raloxifene 5.8216343187
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6811141357
MESH:D009369 Neoplasms Fluorouracil 8.6818600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 8.6817405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.6216707424
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009421 Nervous System Malformations Estradiol 3.8511399458 16427766
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.6516003739 17160924 16651423
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.2517160924
MESH:D010024 Osteoporosis Raloxifene 3.4919059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4115758505 17823083 15579764 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 2.2619401270
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7216929163 15113037 19003803 16500647
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8617292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8618626508 19082440
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8616536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8615084515
MESH:D018202 Pulmonary Blastoma marker/mechanism
MESH:D011693 Purpura Raloxifene 5.8215770314
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1618286688 16160472 18722050 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4419755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.462093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4618396642 17522103 16951190 17172411 16424979 17498489 15786421 18567086 19015929 19084572
MESH:D020521 Stroke Raloxifene 9.1716837676
MESH:D020521 Stroke Vitamin E 9.1716517955
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.4015790496
MESH:D013978 Tibial Fractures Estradiol 14.6219048282
MESH:D013978 Tibial Fractures Raloxifene 14.6219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3617053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.3617572228
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D054556 Venous Thromboembolism Raloxifene 5.4716837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8216343187
Pathway ID Pathway Name
REACT:12472 Regulatory RNA pathways
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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