AutismKB 2.0

Annotation Detail for ZFPM2


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Basic Information Top
Gene Symbol:ZFPM2 ( DIH3,FOG2,MGC129663,MGC129664,ZNF89B,hFOG-2 )
Gene Full Name: zinc finger protein, multitype 2
Band: 8q23
Quick LinksEntrez ID:23414; OMIM: 603693; Uniprot ID:FOG2_HUMAN; ENSEMBL ID: ENSG00000169946; HGNC ID: 16700
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Tetralogy of Fallot
Diaphragmatic hernia 3
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ZFPM2 mRNAdecreases expression 19933214
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ZFPM2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ZFPM2 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ZFPM2 mRNAaffects expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ZFPM2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of ZFPM2 mRNAincreases expression 20106945
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of ZFPM2 geneincreases mutagenesis 16724327
D019833 Genistein Genistein results in decreased expression of ZFPM2 mRNAdecreases expression 15256057
D010656 Phenylephrine ZFPM2 protein results in decreased susceptibility to Phenylephrinedecreases response to substance 15220332
D010656 Phenylephrine ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]affects binding|decreases reaction|increases reaction 15220332
D010656 Phenylephrine ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]decreases reaction|increases activity 15220332
D010656 Phenylephrine ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]decreases reaction|increases expression 15220332
D010656 Phenylephrine ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]decreases reaction|increases expression 15220332
D010656 Phenylephrine ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]decreases reaction|increases expression 15220332
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ZFPM2 mRNAdecreases expression 19933214
18691609
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 15322242 11752688
MESH:D000230 Adenocarcinoma Genistein 2.5111473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.303712494
MESH:D000236 Adenoma Ethylnitrosourea 7.306695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.2717460149
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001919 Bradycardia Phenylephrine 4.7815306635
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0414991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4518412241 16651633 16436596 15144691 16357521
MESH:D001943 Breast Neoplasms Genistein 2.0616541309 17200150 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0620435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916124888 3786805 10355542 16050911 16097048 16227642 18705752 15721981 16011737 15673190 16192424 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.767296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.763084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7618788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.7616924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D006332 Cardiomegaly Phenylephrine 7.1717124262 11179087 11754973 15728586 17287366 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.1718850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.4216332659
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 17.027505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.0220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.0212371664
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 17.0216003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.2517160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.3019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.3019486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 16354765 15340226 8697196 12621046
MESH:D003110 Colonic Neoplasms Genistein 2.3117182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0118759878 2524372 14531868 12868966 11906362 8970840 11298694 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4517107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.327440962 18692083 6679447 18648102 1440618 8291058 9328219 6482804 16192314 18289764 9653073 11289319 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3210915739 16393943 16781746 18713872 18071297 16485898 11287661 19164858 19416960 19420014 17906064 15968718 12705907 11743745 19739265 16109766 12153990 11739529 14725611 11529661 10663392 12594235 11461765 17562736 16177239 19085960 11421492 19370779 10774834 12392966 12958197 15619225 14550746 14986274 16081117 19923254 2444490 11834606 17522070 12540782 16227642
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.3217522070 11566570 15998439 10915739 9327722 15027814 4309450 7179309 6623471 21278145 16227642 3786805 19085960 19336974 15968718 7120509 7440962 2869522 16177239 3732212 6884620 10092053
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.2518357618
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D004714 Endometrial Hyperplasia Genistein 4.8316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4711473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.513581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2915959796 12795759 16045604 12631006 17595544 19224547 16239168 61145
MESH:D005234 Fatty Liver Cyclosporine 8.2919224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Carbon Tetrachloride 16.0218705752
MESH:D005355 Fibrosis Cyclosporine 16.0212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0220067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Ethylnitrosourea 7.8716436596
MESH:D005909 Glioblastoma Genistein 7.8716598420
MESH:D005910 Glioma Ethylnitrosourea 3.5516357521 16651633 18412241
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.896705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.8919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic marker/mechanism 17436238
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 16354765 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Cyclosporine 8.9510903974
MESH:D006973 Hypertension Phenylephrine 8.9512717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.9518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D006984 Hypertrophy Phenylephrine 4.7318502941 12791704
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.108314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.356582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.3512371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 13.3517379185
MESH:D007938 Leukemia Genistein 3.1018980019 17468513
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8917334410 16221502 16239168 21278145 11408273 17174718 17157831 16943688 11903743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5815876570 15730626 18205269 11481614 15338365 15650968 17766677 18412020 12445421 18251166 17805973 17565644 17640975 18472332 18279442 18006644 17721639 18472094 16248980 14512876 18187930 12389079 12632512 18277467 12958196 18376398 15996030 17714472 12586293 14620537 18339082 18395095 18210741 18263696 15362042 15673190 17631135 16027843 17708605 18705752 12741479 12649538 13678700 15057751 17761835 18429990 16192424 16116963 15123356 17481882 10355542 17944888 18418968 20821823 18481824 15893842 17525996 16136751 12632514 12898905 16015684 14748882 14716833 14724832 15370692 16097048 18054572 18156304 18166357 16011737 15925388 17823541 17869086 14716496 16638106 15818738 18317297 18395914 17922224 15959796 17900296 12666154 18420326 15052691 17557913 12546737 12445418 17976157 12609069 16033810 15931870 12667390 17698563
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5817823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5812878042
MESH:D008107 Liver Diseases Acetaminophen 4.0319460945 16610002 12587719 12969438 19784758 16611625 11587558 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0317285989 15830285 15720792 16246199 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.38598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.3815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3812151625
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.626695378 17703301 16019985 16271038
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6211884234 19555203
MESH:D008223 Lymphoma Ethylnitrosourea 4.0615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.2615375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 6.7910767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.7914578162 12929590
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008579 Meningioma Ethylnitrosourea 6.2517943659
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009203 Myocardial Infarction Genistein 2.9217141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7917141266
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.6216707424
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Genistein 10.2816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.6516651423 16003739 17160924
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.584026338 6482804
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.2517160924
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010024 Osteoporosis Genistein 3.3519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2716169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6419005980
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Genistein 3.4415256057 15378649 16925846
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012852 Sinusitis Phenylephrine 4.947327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013771 Tetralogy of Fallot marker/mechanism
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.4015790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.013712494 6587162 7505956 1399818 6582329
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.338074119
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134947303
    • No data
    Releated disease ID Related disease Name
    PA152241952Congenital diaphragmatic hernia
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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