Annotation Detail for KCNH3
Basic Information
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| Gene Symbol: | KCNH3 ( BEC1,ELK2,KIAA1282,Kv12.2 ) |
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| Gene Full Name: | potassium voltage-gated channel, subfamily H (eag-related), member 3 |
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| Band: | 12q13.12 |
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| Quick Links | Entrez ID:23416; OMIM: 604527; Uniprot ID:KCNH3_HUMAN; ENSEMBL ID: ENSG00000135519; HGNC ID: 6252 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C035207 |
4-amino-2,6-dinitrotoluene |
4-amino-2,6-dinitrotoluene affects the expression of KCNH3 mRNA | affects expression | 21346803
|
| D001464 |
Barium |
Barium binds to and results in decreased activity of KCNH3 protein | affects binding|decreases activity | 12193184
|
| D002586 |
Cesium |
Cesium binds to and results in decreased activity of KCNH3 protein | affects binding|decreases activity | 12193184
|
| D007657 |
Ketone Bodies |
Ketone Bodies results in decreased expression of KCNH3 mRNA | decreases expression | 16807920
|
| C006253 |
pirinixic acid |
pirinixic acid results in increased expression of KCNH3 mRNA | increases expression | 18301758
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
4-amino-2,6-dinitrotoluene |
4.49 | 7525203 |
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.52 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.02 | 16434500 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.52 | 19483382 |
| MESH:D002386 |
Cataract |
|
4-amino-2,6-dinitrotoluene |
3.81 | 14694615 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.08 | 19176532 |
| MESH:D000013 |
Congenital Abnormalities |
|
4-amino-2,6-dinitrotoluene |
4.49 | 15095906 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.56 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
4-amino-2,6-dinitrotoluene |
2.71 | 21346803 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.85 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.14 | 20131406 19236843 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.73 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.48 | 19176532 16221962 19772884 18467677 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.53 | 20558911 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.85 | 16306350 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.92 | 15890375 20007298 16377806 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.99 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.26 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.22 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.09 | 17405874 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.88 | 20558911 |
| MESH:D009784 |
Occupational Diseases |
|
4-amino-2,6-dinitrotoluene |
4.44 | 14694615 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.53 | 19058328 |
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