AutismKB 2.0

Annotation Detail for SLC7A8


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Basic Information Top
Gene Symbol:SLC7A8 ( LAT2,LPI-PC1 )
Gene Full Name: solute carrier family 7 (amino acid transporter, L-type), member 8
Band: 14q11.2
Quick LinksEntrez ID:23428; OMIM: 604235; Uniprot ID:LAT2_HUMAN; ENSEMBL ID: ENSG00000092068; HGNC ID: 11066
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04974Protein digestion and absorption
Pathway IDPathway Name
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
Hemostasis
Metabolism of amino acids and derivatives
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SLC7A8 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC7A8 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of SLC7A8 mRNAincreases expression 20458559
D002945 Cisplatin SLC7A8 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004041 Dietary Fats Dietary Fats results in decreased expression of SLC7A8 mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in decreased expression of SLC7A8 mRNAdecreases expression 16002434
D004281 Docosahexaenoic Acids PPARA protein promotes the reaction [Docosahexaenoic Acids results in decreased expression of SLC7A8 mRNA]decreases expression|increases reaction 18489776
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of SLC7A8 mRNAaffects cotreatment|increases expression 17404688
D000431 Ethanol Ethanol results in decreased expression of SLC7A8 mRNAdecreases expression 17920746
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC7A8 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC7A8 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC7A8 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SLC7A8 mRNAdecreases expression 15901920
D009151 Mustard Gas Mustard Gas results in increased expression of SLC7A8 mRNAincreases expression 15674844
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of SLC7A8 mRNAincreases expression 17616710
C041786 palm oil palm oil results in decreased expression of SLC7A8 mRNAdecreases expression 18042831
D010795 Phthalic Acids Phthalic Acids results in decreased expression of SLC7A8 mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid results in decreased expression of SLC7A8 mRNAdecreases expression 17426115
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of SLC7A8 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of SLC7A8 mRNAincreases expression 17404688
D012643 Selenium Selenium results in increased expression of SLC7A8 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of SLC7A8 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC7A8 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC7A8 mRNAincreases expression 17942748
D014050 Toluene Toluene affects the expression of SLC7A8 mRNAaffects expression 18653662
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4714745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.1918926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1915322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 10.1818287403
MESH:D000138 Acidosis Ethanol 10.1811192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.8817670903 15814532 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 10.0111798837 19825857
MESH:D000230 Adenocarcinoma Cisplatin 10.0117638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 10.0111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.0114692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.6216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.6216835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.2415451039 15451040
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D000853 Anophthalmos Ethanol 4.7315513904
MESH:D001008 Anxiety Disorders Ethanol 3.9311141031
MESH:D001161 Arteriosclerosis Dietary Fats 9.6215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.6211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6115885639
MESH:D001249 Asthma Mustard Gas 2.6810378619
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.3020106747
MESH:D001321 Autistic Disorder Acetaminophen 2.2918445737
MESH:D001321 Autistic Disorder Docosahexaenoic Acids 2.2918582451
MESH:D001768 Blister Mustard Gas 5.0719167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.8016206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.8019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8014601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2617868700
MESH:D001930 Brain Injuries Progesterone 4.1715665606 15380490 15845082
MESH:D001943 Breast Neoplasms Calcitriol 3.7211237771
MESH:D001943 Breast Neoplasms Cisplatin 3.7219526202 18382427
MESH:D001943 Breast Neoplasms Dietary Fats 3.7220435547
MESH:D001943 Breast Neoplasms Estradiol 3.7217018787 16675129 19861407 12948864 18497071 17261762 17289903 14630087
MESH:D001943 Breast Neoplasms Progesterone 3.7217614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tamoxifen 3.7219221464 17440819 19066611 19288272 19155303 19410462 18629630 21138602 18821012 21152245 15668708 19011961 20065188 17261762 15565566 17049068 18815881 19200415 18855134 19084267 17893378 16873071 19189210 19487384 19059307 16273361 18351453 20859285 20544844 17242785 19289846 20390343 16818667 11161223 19142967 20005174 19244106 16202921 18984771 18997820 18425577 19103187 20135344 19115204 19189212
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7220435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9017687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2411589617
MESH:D002056 Burns Ethanol 4.5616374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.223084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.2215073043 16217749 14691202 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 11.2217982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.2216924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 11.2215289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.2216924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0112023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0412490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8911237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.896189445 17066447 18337622
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5317572228
MESH:D006332 Cardiomegaly Ethanol 6.6819332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6818850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.7118566989
MESH:D002547 Cerebral Palsy Toluene 5.769294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5211677210 16919318 15861022 17333356 16105132 17681005 17110522
MESH:D002779 Cholestasis pirinixic acid 7.5219176532
MESH:D002971 Cleft Lip Ethanol 3.5415513904
MESH:D002972 Cleft Palate Ethanol 5.8315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8315340226 16354765 15668235 8697196 12621046
MESH:D003092 Colitis Selenium 3.6917936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6520501625
MESH:D015179 Colorectal Neoplasms Cisplatin 2.6515273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.3910525206
MESH:D019465 Craniofacial Abnormalities Ethanol 5.3919302082 15513904 11198716 15451039 10194807 11873399 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3910048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 5.399294310
MESH:D003550 Cystic Fibrosis Docosahexaenoic Acids 4.5919747007
MESH:D003643 Death Toluene 5.596431079
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0115213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2819031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.5819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.5819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4117187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.7615968718 10663392 17522070 19739265 18071297 18713872 11461765 14725611 19085960 11739529 10915739 14550746 17906064 12153990 16227642 11743745 19416960 12540782 12594235 2444490 11834606 19923254 16177239 16781746 16109766 15619225 19370779 11529661 16081117 12705907 12392966 16393943 17562736 16485898 19420014 19164858 12958197 11287661 14986274 10774834 11421492
MESH:D056486 Drug-Induced Liver Injury Ethanol 8.7611566570
MESH:D056486 Drug-Induced Liver Injury Selenium 8.7615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.7620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Cisplatin 7.9615033597 12649298 19839026 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.9611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3918367378
MESH:D004487 Edema Mustard Gas 10.9511428647 11428631 11402378 9260866
MESH:D004487 Edema pirinixic acid 10.9512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.9512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 21.2215138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 21.2212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 21.2217692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 21.2219031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.2019148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.2017893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Progesterone 8.6616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.669294722 10568697
MESH:D004890 Erythema Mustard Gas 5.079357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.3012903497
MESH:D004938 Esophageal Neoplasms Cisplatin 10.3016785472 15173087 15464296 16481741 17638652
MESH:D004938 Esophageal Neoplasms Ethanol 10.3016704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 10.3015264214 16704527 15623463 15150132 16510608 15878914 15547721 15547733 16805852
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver arsenic trioxide 29.6715073043
MESH:D005234 Fatty Liver Dietary Fats 29.6719004024 18296743 19551842 17967931
MESH:D005234 Fatty Liver Ethanol 29.6719236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.6715345470
MESH:D005234 Fatty Liver pirinixic acid 29.6720131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 29.6719224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.5817920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1816709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.2115513904 10194807 15451040 16946407
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1019069698
MESH:D005355 Fibrosis Dietary Fats 8.3318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3320067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1816904648
MESH:D005756 Gastritis Acetaminophen 10.8616983495
MESH:D005756 Gastritis Ethanol 10.8615046732
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.6515102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.2219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3415464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 6.7720558911
MESH:D006333 Heart Failure Selenium 6.7717162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly pirinixic acid 7.9719772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9712621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D006689 Hodgkin Disease Cisplatin 3.5216170182 16200630
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.968697196 18606429 16354765 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 7.5716870215
MESH:D006930 Hyperalgesia Ethanol 7.5718783367
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5121332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5321332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4317937319
MESH:D007249 Inflammation Dietary Fats 15.3820412841
MESH:D007249 Inflammation Mustard Gas 15.3817524151 11428647 9357497 16001271 11428620 9260866 8975870 11428631 11402378
MESH:D007249 Inflammation Progesterone 15.3815869954
MESH:D007249 Inflammation Tamoxifen 15.3819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.3812878042 12200463
MESH:D007251 Influenza, Human Selenium 4.1216624496
MESH:D007333 Insulin Resistance Dietary Fats 11.9618457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.9616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.9616306350
MESH:D007569 Jaw Abnormalities Ethanol 9.8415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8416580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.0615464296
MESH:D007674 Kidney Diseases Acetaminophen 9.8015629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 9.8018289764 19839026 12649298 12231392 15190930
MESH:D007674 Kidney Diseases Estradiol 9.8015618244
MESH:D007676 Kidney Failure, Chronic Selenium 3.8016518626
MESH:D007680 Kidney Neoplasms Estradiol 7.1415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 7.1418625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7111231351
MESH:D007859 Learning Disorders Ethanol 4.1215451040
MESH:D007938 Leukemia arsenic trioxide 2.7915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.7817077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Docosahexaenoic Acids 9.7817077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6819077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1219850784 16968895 20471514 16467208 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1619642359 19225113 15748426 12018890 19035177 19075265 17712046 16966277 12712474 15213294 17649720 12679006 9834237 17869043 16331271 16891316 17107899 11161223 17217047 15622746 16330433 16112521 15336539 16823087 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2716882451
MESH:D017880 Limb Deformities, Congenital Ethanol 3.7517676605
MESH:D008064 Lipidoses Tamoxifen 3.0917567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 6.6818296743
MESH:D008103 Liver Cirrhosis Ethanol 6.6815289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.0118295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.6118166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.6118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6112878042
MESH:D008107 Liver Diseases Acetaminophen 4.3119784758 19460945 12969438 16610002 19014921 12587719 11587558 16611625
MESH:D008107 Liver Diseases Docosahexaenoic Acids 4.3117056761
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.5617347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1616871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 10.4014682389
MESH:D008113 Liver Neoplasms pirinixic acid 10.4020007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 10.4016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.4016984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.6220377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2815213294
MESH:D008171 Lung Diseases Mustard Gas 3.3918161513 18702808
MESH:D008175 Lung Neoplasms arsenic trioxide 6.4811798837 19825857
MESH:D008175 Lung Neoplasms Cisplatin 6.4811798837 17225452 6189445
MESH:D008175 Lung Neoplasms Mustard Gas 6.488781369 3148597
MESH:D008175 Lung Neoplasms Tamoxifen 6.4818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4819555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.8016891317 17203775 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.8017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 13.8015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.8016827153 19196722 11731420 19196723 14580682
MESH:D020149 Manganese Poisoning Estradiol 12.3819453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.3819453300
MESH:D008545 Melanoma Cisplatin 3.4318505091 16248763 12393984 12374674 16432458 17761969 18176117 18332650 15577323 11135225 16809738 12883367 17023156
MESH:D008545 Melanoma Tamoxifen 3.4319393235 12393984
MESH:D018328 Melanoma, Amelanotic Cisplatin 11.2215990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 11.2215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008569 Memory Disorders Ethanol 4.1015451040 18411066
MESH:D008607 Mental Retardation Toluene 3.629294310
MESH:D008654 Mesothelioma Cisplatin 6.2417638057
MESH:D008654 Mesothelioma Selenium 6.2415107826
MESH:D019957 Motor Skills Disorders Toluene 5.159294310
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0419549372 11468182 15949261 19417148 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0916105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0216411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8716624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Cisplatin 4.9616773208
MESH:D009369 Neoplasms pirinixic acid 4.9617405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9219196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4115464296
MESH:D009421 Nervous System Malformations Estradiol 9.1816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1814600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0610525206
MESH:D009447 Neuroblastoma Cisplatin 3.408761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.618761367
MESH:D009503 Neutropenia Mustard Gas 3.897688884 16761898
MESH:D009765 Obesity Dietary Fats 4.3617217161 20518802 18674790 11836018 21332399 18457598 16723640 20132043 19632207
MESH:D009765 Obesity pirinixic acid 4.3620558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.0912452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Cisplatin 11.0915464296 17225452 19769630 6897625
MESH:D010051 Ovarian Neoplasms Estradiol 11.0919401270
MESH:D010051 Ovarian Neoplasms Progesterone 11.0917393432 16525653
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.5815580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.5819003803
MESH:D010190 Pancreatic Neoplasms Ethanol 8.5812384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2215464296
MESH:D010954 Plasmacytoma Selenium 4.8115087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.2617638057
MESH:D011041 Poisoning Mustard Gas 3.7115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1111118676 11222880 11399792 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0919131511
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0918247401 16644109 15754350 12479363 16289102
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 9.2416919318 15861022
MESH:D011537 Pruritus Mustard Gas 9.2418058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8917720292 17266442 10334151 17894541 17620002
MESH:D051437 Renal Insufficiency Cisplatin 4.3215464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.0616646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 10.0614601052
MESH:D012640 Seizures Ethanol 6.349754883
MESH:D012640 Seizures Toluene 6.349294310 6431079
MESH:D012871 Skin Diseases Mustard Gas 2.6912880345 16961503 15451306
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0016192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.2615464296
MESH:D013088 Spermatocele Ethinyl Estradiol 11.2916709447
MESH:D013088 Spermatocele Tamoxifen 11.2916709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.5916503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.5919457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.3517007042
MESH:D013274 Stomach Neoplasms Cisplatin 6.3517522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Docosahexaenoic Acids 6.3519015929
MESH:D013274 Stomach Neoplasms Ethanol 6.3518456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 6.3512958204 17575124
MESH:D013276 Stomach Ulcer Ethanol 3.4511906479 9562338 9211565 17918041 16755016 17189318
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.179754883
MESH:D013733 Testicular Diseases Toluene 4.8710514026 10048760
MESH:D013736 Testicular Neoplasms Cisplatin 4.5515464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.0219014326
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8815213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.2020435036 12973940 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.2012973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.208653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.1316803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5215577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D014839 Vomiting Cisplatin 4.6411897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D015430 Weight Gain Dietary Fats 3.6616723640
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
REACT:604 Hemostasis
REACT:13 Metabolism of amino acids and derivatives
KEGG:04974 Protein digestion and absorption
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35926
    • No data
    No data
    Releated drug ID Related drug Name
    PA448055l-alanine
    PA448478l-arginine
    PA450197l-leucine
    PA450280l-lysine
    PA451330l-serine
    PA451822l-tyrosine
    PA451843l-valine
    PA451590taurine
    PA10323l-tryptophan
    PA449789glycine
    PA449173l-cysteine
    PA451125l-proline
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00120 - L-Phenylalanine Dietary supplement;Micronutrient;Essential Amino Acids
    DB00130 - L-Glutamine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00160 - Travasol Amino Acid Injection Without Electrolytes Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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