AutismKB 2.0

Annotation Detail for SLC35A3


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Basic Information Top
Gene Symbol:SLC35A3 ( DKFZp781P1297 )
Gene Full Name: solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
Band: 1p21.2
Quick LinksEntrez ID:23443; OMIM: 605632; Uniprot ID:S35A3_HUMAN; ENSEMBL ID: ENSG00000117620; HGNC ID: 11023
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500363Transport of nucleotide sugars
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of SLC35A3 mRNAincreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of SLC35A3 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC35A3 mRNAdecreases expression 19150397
20018196
D010269 Paraquat Paraquat affects the expression of SLC35A3 mRNAaffects expression 16854511
D010634 Phenobarbital Phenobarbital results in increased expression of SLC35A3 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of SLC35A3 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.906195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.7117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.7116434500
MESH:D000382 Agricultural Workers' Diseases Paraquat 4.2211874814
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.753084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.756705139 20935162 20007298 17173139 1701930
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.356135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3520889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9711739529 11421492 18071297 19164858 10663392 14725611 16393943 12958197 12153990 19416960 19370779 11834606 11529661 19085960 10915739 19739265 12705907 15619225 14550746 17906064 11743745 11461765 12540782 17522070 18713872 16177239 11287661 14986274 12392966 19923254 17562736 15968718 16485898 2444490 12594235 16081117 16227642 16109766 19420014 16781746 10774834
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.3911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver pirinixic acid 3.0920131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005911 Gliosis Paraquat 5.6811124998
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly Phenobarbital 9.9016109766
MESH:D006529 Hepatomegaly pirinixic acid 9.9019772884 16221962 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007248 Infertility, Male Paraquat 3.454850670
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2416705839
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0521047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.1512587719 16611625 16610002 19784758 11587558 12969438 19014921 19460945
MESH:D008107 Liver Diseases Phenobarbital 4.1519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.997678174
MESH:D008113 Liver Neoplasms Phenobarbital 7.9919812893 21047994 15975961 8742319 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 7.9915890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.562876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.562563599 18308698 1399818 17172636 6150874
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.3218551238 7678174
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009410 Nerve Degeneration Paraquat 3.9616893418
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7416049721
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5816965848
MESH:D010300 Parkinson Disease Paraquat 2.9111445065 11124998 15451049 12911755 16510128 11181820 15824117 16140633
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.8516190885
MESH:D011014 Pneumonia Paraquat 4.9112504350
MESH:D011230 Precancerous Conditions Phenobarbital 3.912563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D011658 Pulmonary Fibrosis Paraquat 3.0117997886 16324872
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.2611700416
MESH:D012135 Respiratory Sounds Paraquat 4.4711874814
MESH:D012162 Retinal Degeneration Paraquat 4.1016458197
MESH:D012640 Seizures 2,6-dinitrotoluene 6.6218551238
MESH:D012640 Seizures Phenobarbital 6.623137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.291399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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