AutismKB 2.0

Annotation Detail for HEY1


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Basic Information Top
Gene Symbol:HEY1 ( BHLHb31,CHF2,HERP2,HESR1,HRT-1,MGC1274,OAF1 )
Gene Full Name: hairy/enhancer-of-split related with YRPW motif 1
Band: 8q21.13
Quick LinksEntrez ID:23462; OMIM: 602953; Uniprot ID:HEY1_HUMAN; ENSEMBL ID: ENSG00000164683; HGNC ID: 4880
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200196Notch-mediated HES/HEY network
Pathway IDPathway Name
P00045Notch signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of HEY1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HEY1 mRNAaffects expression 16483693
C006680 baicalein baicalein results in increased expression of HEY1 mRNAincreases expression 19160421
C006680 baicalein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA]decreases reaction|increases expression 19160421
C038044 baicalin baicalin results in increased expression of HEY1 mRNAincreases expression 19160421
C038044 baicalin N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]decreases reaction|increases expression 19160421
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of HEY1 mRNAincreases expression 16934159
D016572 Cyclosporine Cyclosporine results in increased expression of HEY1 mRNAincreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HEY1 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of HEY1 mRNAincreases expression 19619570
D004958 Estradiol Estradiol affects the expression of HEY1 mRNAaffects expression 15598610
D016685 Mitomycin HEY1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D009151 Mustard Gas Mustard Gas results in increased expression of HEY1 mRNAincreases expression 15674844
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA]decreases reaction|increases expression 19160421
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]decreases reaction|increases expression 19160421
C030110 oxaliplatin oxaliplatin results in decreased expression of HEY1 mRNAdecreases expression 17762391
D010126 Ozone Ozone results in decreased expression of HEY1 mRNAdecreases expression 12763052
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HEY1 mRNAincreases expression 16443690
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HEY1 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HEY1 mRNAincreases expression 19619570
20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000544 Alzheimer Disease Ozone 2.4515513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5715570426
MESH:D001249 Asthma Mustard Gas 5.1610378619
MESH:D001249 Asthma Ozone 5.1616373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Estradiol 1.9312948864 17261762 17289903 16675129 17018787 14630087 19861407 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7418315731 17626835 18417511 14754758 15516495 19059883 16777450
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1117687719 10378619
MESH:D002100 Cachexia Ozone 4.8616183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.853084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.8516924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7618566989
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 20868653
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 2.9719486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315340226 12621046 8697196 16354765 15668235
MESH:D003110 Colonic Neoplasms oxaliplatin 3.1816024531 16004971 16510598
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.9418509181 18448328 17695437 17594712 17401013 17255274
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.382444490 19085960 16393943 15968718 10774834 12705907 11739529 11287661 12594235 16227642 12958197 19739265 12153990 16081117 19164858 14986274 19923254 10915739 11529661 18071297 15619225 16109766 12540782 17522070 16485898 17906064 18713872 11421492 19370779 11834606 14550746 16177239 17562736 11461765 12392966 16781746 10663392 19416960 19420014 14725611 11743745
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 6.3817851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Mustard Gas 7.1111428647 9260866 11428631 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 18230668 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.0311473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 2.9419224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis baicalein 22.2519474275
MESH:D005355 Fibrosis baicalin 22.2519474275
MESH:D005355 Fibrosis Cyclosporine 22.2512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.2520067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma baicalein 4.8919804834
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 8.2616870215
MESH:D006930 Hyperalgesia oxaliplatin 8.2617418472
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D007249 Inflammation Mustard Gas 5.188975870 9357497 9260866 11428631 17524151 11428647 11428620 16001271 11402378
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.0216627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.2415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.248314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.2415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5012371664
MESH:D007680 Kidney Neoplasms Estradiol 7.5015610895
MESH:D008106 Liver Cirrhosis, Experimental baicalin 3.7618187930
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.7614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7612878042
MESH:D008107 Liver Diseases Acetaminophen 1.6512969438 16611625 19784758 11587558 19460945 16610002 19014921 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms Mitomycin 4.8715113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1512151625
MESH:D008171 Lung Diseases Mustard Gas 7.8018702808 18161513
MESH:D008171 Lung Diseases Ozone 7.8019066396 8266340
MESH:D055370 Lung Injury Ozone 3.9520417186
MESH:D008175 Lung Neoplasms Mustard Gas 3.523148597 8781369
MESH:D008175 Lung Neoplasms Ozone 3.527614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5211884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6111807958 17203775 11408345 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D008679 Metaplasia Ozone 5.2410496685
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.7816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009503 Neutropenia Mustard Gas 4.0616761898 7688884
MESH:D010051 Ovarian Neoplasms Estradiol 2.2419401270
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Mitomycin 3.4715113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010538 Peritonitis Ozone 4.2316369182
MESH:D011014 Pneumonia Ozone 4.5118007984 18929643 18381685
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111222880 11399792 11896295 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms baicalin 3.9315714805
MESH:D011471 Prostatic Neoplasms Estradiol 3.9316740699
MESH:D011537 Pruritus Mustard Gas 4.2118058305
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9517266442 10334151 17894541 17620002 17720292
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012871 Skin Diseases Mustard Gas 2.7312880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29258
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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