AutismKB 2.0

Annotation Detail for HEY1


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Basic Information Top
Gene Symbol:HEY1 ( BHLHb31,CHF2,HERP2,HESR1,HRT-1,MGC1274,OAF1 )
Gene Full Name: hairy/enhancer-of-split related with YRPW motif 1
Band: 8q21.13
Quick LinksEntrez ID:23462; OMIM: 602953; Uniprot ID:HEY1_HUMAN; ENSEMBL ID: ENSG00000164683; HGNC ID: 4880
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
200196Notch-mediated HES/HEY network
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of HEY1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HEY1 mRNAaffects expression 16483693
C006680 baicalein baicalein results in increased expression of HEY1 mRNAincreases expression 19160421
C006680 baicalein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA]decreases reaction|increases expression 19160421
C038044 baicalin baicalin results in increased expression of HEY1 mRNAincreases expression 19160421
C038044 baicalin N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]decreases reaction|increases expression 19160421
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of HEY1 mRNAincreases expression 16934159
D016572 Cyclosporine Cyclosporine results in increased expression of HEY1 mRNAincreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HEY1 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of HEY1 mRNAincreases expression 19619570
D004958 Estradiol Estradiol affects the expression of HEY1 mRNAaffects expression 15598610
D016685 Mitomycin HEY1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D009151 Mustard Gas Mustard Gas results in increased expression of HEY1 mRNAincreases expression 15674844
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA]decreases reaction|increases expression 19160421
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]decreases reaction|increases expression 19160421
C030110 oxaliplatin oxaliplatin results in decreased expression of HEY1 mRNAdecreases expression 17762391
D010126 Ozone Ozone results in decreased expression of HEY1 mRNAdecreases expression 12763052
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HEY1 mRNAincreases expression 16443690
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HEY1 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HEY1 mRNAincreases expression 19619570
20106945
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29258
  • Releated disease ID Related disease Name
    PA445062Neoplasms
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018