AutismKB 2.0

Annotation Detail for GCAT


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Basic Information Top
Gene Symbol:GCAT ( KBL,MGC23053 )
Gene Full Name: glycine C-acetyltransferase
Band: 22q13.1
Quick LinksEntrez ID:23464; OMIM: 607422; Uniprot ID:KBL_HUMAN; ENSEMBL ID: ENSG00000100116; HGNC ID: 4188
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
THREONINE-DEG2-PWYthreonine degradation II
Pathway IDPathway Name
hsa00260Glycine, serine and threonine metabolism
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of GCAT mRNAincreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GCAT mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of GCAT mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GCAT mRNAaffects expression 17484886
C056933 fumonisin B1 fumonisin B1 results in decreased expression of GCAT mRNAdecreases expression 16221962
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of GCAT mRNAincreases expression 20713471
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in decreased expression of GCAT proteindecreases expression 19474218
C006253 pirinixic acid pirinixic acid results in decreased expression of GCAT mRNAdecreases expression 16221962
17426115
D012643 Selenium Selenium results in increased expression of GCAT mRNAincreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of GCAT mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GCAT mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0414514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000236 Adenoma Methylcholanthrene 3.576695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5311922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.0411921183
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0420435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9518705752 15721981 16011737 15700767 16192424 15673190 16124888 16227642 10355542 16050911 16097048 3786805
MESH:D002277 Carcinoma Methylcholanthrene 8.7110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.633084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6318788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.5916192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 8697196 15668235 15340226 16354765
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.7818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.7811739529 19416960 12153990 10915739 12392966 19739265 12705907 11287661 15619225 16081117 12540782 17522070 10774834 11421492 11529661 16109766 17562736 18071297 18713872 17906064 14725611 11461765 19923254 15968718 2444490 12958197 16781746 11834606 16393943 14986274 14550746 16227642 11743745 16177239 19370779 19164858 10663392 19085960 16485898 12594235 19420014
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.7810915739 16177239 7179309 19336974 15027814 7120509 16227642 11566570 15968718 10092053 9327722 15998439 21278145 3732212 2869522 6623471 19085960 3786805 7440962 6884620 4309450 17522070
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 15.7816221962
MESH:D056486 Drug-Induced Liver Injury Selenium 15.7815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1416045604 12631006 19224547 12795759 17595544 15959796 61145 16239168
MESH:D005234 Fatty Liver pirinixic acid 8.1420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1310962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 9.1918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.1920067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 4.3517162496
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4011294989 10048152
MESH:D006333 Heart Failure pirinixic acid 7.2220558911
MESH:D006333 Heart Failure Selenium 7.2217162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly fumonisin B1 15.5516221962
MESH:D006529 Hepatomegaly pirinixic acid 15.5516221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.5515340226 16120746 12621046
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9617440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212200463 12878042
MESH:D007251 Influenza, Human Selenium 4.4116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0916705839
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8811408273 11903743 17174718 16943688 16239168 16221502 17334410 17157831 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4618420326 18472094 17481882 17761835 16033810 12389079 14748882 17714472 11481614 14620537 17900296 18412020 14716833 12666154 16136751 18376398 16097048 17721639 17869086 17823541 18472332 18395914 12609069 17922224 18277467 18279442 18395095 12632514 14724832 15730626 20821823 15338365 17565644 17805973 17976157 14716496 18156304 18205269 12445421 18006644 17944888 12445418 18317297 13678700 15959796 15931870 16116963 17708605 15057751 16248980 18705752 16015684 15052691 15925388 12632512 14512876 16192424 10355542 16011737 15370692 17631135 15673190 18418968 17698563 18429990 18251166 15362042 18210741 18339082 17557913 18187930 12898905 15123356 16638106 17640975 12546737 17766677 18054572 18481824 15818738 18166357 12649538 18263696 17525996 15876570 12741479 12586293 16027843 12667390 15650968 15893842 12958196 15996030
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Acetaminophen 4.0019014921 12587719 19784758 19460945 12969438 16611625 16610002 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0017285989 16964402 15830285 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.6119294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.6116377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6116984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.3712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 10.37598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3712151625
MESH:D008175 Lung Neoplasms Methylcholanthrene 2.537750092 15390079 11893704 1399818 10545420 9230183 21163286 20970405 6695378 16337739 17909032 16271038 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5319555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 6.6811921183
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6815318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0518551238
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5616049721 12819281
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11118676 11399792 11222880
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6218551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3316049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:00260 Glycine, serine and threonine metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00114 - Pyridoxal Phosphate Dietary supplement;Micronutrient;Vitamin B Complex
DB00145 - Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
No data
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No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018