AutismKB 2.0

Annotation Detail for CBX6


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Basic Information Top
Gene Symbol:CBX6 ( - )
Gene Full Name: chromobox homolog 6
Band: 22q13.1
Quick LinksEntrez ID:23466; OMIM: NA; Uniprot ID:CBX6_HUMAN; ENSEMBL ID: ENSG00000183741; HGNC ID: 1556
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CBX6 mRNAaffects expression 17562736
D001104 Arbutin Arbutin results in decreased expression of CBX6 mRNAdecreases expression 17103032
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CBX6 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of CBX6 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CBX6 mRNAaffects cotreatment|affects expression 17602206
D019833 Genistein Genistein results in decreased expression of CBX6 mRNAdecreases expression 16705744
D012645 Selenomethionine Selenomethionine affects the expression of CBX6 mRNAaffects expression 17222674
D014810 Vitamin E Vitamin E results in increased expression of CBX6 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Genistein 2.5211473722
MESH:D000236 Adenoma Diethylnitrosamine 2.9810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2416434500 19052882 17162532 19061943 18056438 17620307
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2517474063
MESH:D001943 Breast Neoplasms Genistein 2.2516873071 17200150 16541309
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.753084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.753581430 18210153 20524982 16569478 20935162 16878318 16830150 19052882 11831363 20727157 19335982 3084413 16698587 20214788 19519916 16935385 21159647 18788625 19701751 17761372 20007298 16328049 18785209 16502159 16807293 20514400 17138121 18393292 19539802 20512989 17428255 19208518 19171122 18494052 18978308 18971187 17173139 10737359 20084675 17055752 16288022 19107877 16779866 17162532 19394651 20432363 16540662 20101231 18506893 16681979 17978847 19418558 19822196 19919837 19383236 18665156 18691550 10672840 18056438
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7516924424
MESH:D002318 Cardiovascular Diseases Genistein 3.4616332659
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.142727394 7505956 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.6920387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.6916647724
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9419370779 10663392 10774834 14725611 14550746 11461765 12540782 18713872 12153990 16781746 11529661 12705907 16393943 19416960 12392966 18071297 11739529 12958197 11743745 19420014 16485898 10915739 17562736 15968718 19085960 17522070 2444490 16109766 19923254 16081117 11834606 16177239 14986274 11421492 19739265 19164858 15619225 12594235 16227642 11287661 17906064
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9419107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004714 Endometrial Hyperplasia Genistein 4.9316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5111473722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005234 Fatty Liver Cyclosporine 8.5319224547
MESH:D005234 Fatty Liver Diethylnitrosamine 8.5321071580 20387270
MESH:D005355 Fibrosis Cyclosporine 3.4512639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Genistein 3.4016598420
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1016080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007251 Influenza, Human Vitamin E 4.5916624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.7515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.758314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.7512488133
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D007938 Leukemia Genistein 3.1317468513 18980019
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9419638242 18407596 18522880 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.7017823541
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.7016169303
MESH:D008107 Liver Diseases Acetaminophen 4.0816611625 19784758 11587558 12969438 12587719 19460945 16610002 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0817034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Clofibric Acid 5.0217602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.0218754104 19833225 18644402 2862719 19294768 21071580 19812893 12112319 20452335 10737359 18977376 19996281 19551842 20583210 20101389 12771043 19090486 19499222 19642983 19256749 15175105 19073162 19254457 19255062 20501860 19426721 2422723 16942905 18978307 20405173 15885732 21167192 18648771 9163691 19850985 20492335 20118626 21278145 20434301 19690152 19427195 19638242 20137499 21047994
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7717174075 18093689 19004024 9362446 17854601 16842330 21159647 18282651 18308698 19126423 2563599 18164116 19539802 17942915 19009564 18253720 18775883 3124819 16267830 19519916 18544905 18079962
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5521163286 20512841 20970405 6695378
MESH:D008175 Lung Neoplasms Vitamin E 2.5511062179
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0814578162 12929590
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009203 Myocardial Infarction Genistein 2.9417141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8417141266
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Genistein 4.3116427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D010024 Osteoporosis Genistein 3.3919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3516169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6619005980
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D011230 Precancerous Conditions Cyclosporine 9.6712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.672563599
MESH:D011471 Prostatic Neoplasms Genistein 3.3215256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3215084515
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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