AutismKB 2.0

Annotation Detail for PHF3


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Basic Information Top
Gene Symbol:PHF3 ( KIAA0244,MGC142210,MGC142212 )
Gene Full Name: PHD finger protein 3
Band: 6q12
Quick LinksEntrez ID:23469; OMIM: 607789; Uniprot ID:PHF3_HUMAN; ENSEMBL ID: ENSG00000118482; HGNC ID: 8921
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PHF3 mRNAaffects expression 21346803
D006710 Homocysteine Homocysteine results in decreased expression of PHF3 mRNAdecreases expression 17326132
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PHF3 mRNAdecreases expression 19150397
D003010 Clorgyline Clorgyline results in increased expression of PHF3 mRNAincreases expression 19691856
D012402 Rotenone Rotenone results in increased expression of PHF3 mRNAincreases expression 19013527
D012643 Selenium Selenium results in decreased expression of PHF3 mRNAdecreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of PHF3 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PHF3 mRNAincreases expression 19465110
D014810 Vitamin E Vitamin E results in decreased expression of PHF3 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 11752688 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001321 Autistic Disorder Homocysteine 3.0316297937 20468076
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7716705839
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 15340226 16354765 15668235 12621046
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D003324 Coronary Artery Disease Homocysteine 3.8216379339
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5319769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D017889 Exfoliation Syndrome Homocysteine 5.9916504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005901 Glaucoma Homocysteine 5.5116504073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Homocysteine 11.8619638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.8610048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 11.8616080930
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1512621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0617440010
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616354765 15340226 16959395 8697196 18606429
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.8918234410 17292331 17369066
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512878042 12200463
MESH:D007251 Influenza, Human Selenium 12.0416624496
MESH:D007251 Influenza, Human Vitamin E 12.0416624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Vitamin E 2.9112488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1416705839
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3916169303
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 2.3511062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008591 Meningomyelocele Homocysteine 5.7916602021
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D009203 Myocardial Infarction Homocysteine 3.7917412321
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009410 Nerve Degeneration Rotenone 4.0417356569 15790535 18619942
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6216049721 12819281
MESH:D010300 Parkinson Disease Homocysteine 6.0816275827
MESH:D010300 Parkinson Disease Rotenone 6.0819114014 16412576 11445065 16140633 11535288 15451049 19232380 18191903 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 4.2718197244 15574749 15795934 15927086
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811222880 11896295 11118676 11399792
MESH:D011471 Prostatic Neoplasms Clorgyline 3.6319691856
MESH:D011471 Prostatic Neoplasms Vitamin E 3.6315084515
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012559 Schizophrenia Homocysteine 3.1316641680
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3516049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33261
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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