AutismKB 2.0

Annotation Detail for TRAM1


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Basic Information Top
Gene Symbol:TRAM1 ( PNAS8,PRO1292,TRAM,TRAMP )
Gene Full Name: translocation associated membrane protein 1
Band: 8q13.3
Quick LinksEntrez ID:23471; OMIM: 605190; Uniprot ID:TRAM1_HUMAN; ENSEMBL ID: ENSG00000067167; HGNC ID: 20568
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TRAM1 mRNAincreases expression 18648102
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRAM1 mRNAdecreases expression 20018196
C053541 bicalutamide bicalutamide results in increased expression of TRAM1 mRNAincreases expression 16631469
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TRAM1 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of TRAM1 mRNAincreases expression 20106945
D002945 Cisplatin Cisplatin results in decreased expression of TRAM1 mRNAdecreases expression 16061661
D004041 Dietary Fats Dietary Fats results in increased expression of TRAM1 mRNAincreases expression 18042831
D004958 Estradiol Estradiol results in increased expression of TRAM1 mRNAincreases expression 17823450
D004958 Estradiol Estradiol results in decreased expression of TRAM1 mRNAdecreases expression 20068009
C011890 kojic acid kojic acid results in decreased expression of TRAM1 mRNAdecreases expression 16595896
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of TRAM1 mRNAincreases expression 12634122
C041786 palm oil palm oil results in increased expression of TRAM1 mRNAincreases expression 18042831
D017632 Asbestos, Serpentine Asbestos, Serpentine results in increased expression of TRAM1 mRNAincreases expression 16251409
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.0717670903 12690470 15814532
MESH:D000230 Adenocarcinoma Cisplatin 4.6517638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 4.6511473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.813712494
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D001195 Asbestosis Asbestos, Serpentine 5.8010751356
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1911289319 1440618
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.0614601052
MESH:D001943 Breast Neoplasms Cisplatin 1.9718382427 19526202
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Estradiol 1.9718497071 16675129 19861407 12948864 17289903 17261762 17018787 14630087
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.747296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.7417982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7416924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0716685392 12023789
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8518337622 17066447 6189445
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 21.937505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 21.9320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.9312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 21.9318566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 21.932727394
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.1519486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.1519486331
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9411298694 14531868 8970840 2524372 18759878 8156756 12868966 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.612952479 3621924
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 1.989022650 6679447 8291058 16192314 11289319 7440962 18289764 1440618 6482804 9328219 9653073 18648102 18692083
MESH:D004362 Drug Toxicity Cisplatin 3.9412231392 12649298 19839026 15033597
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D016889 Endometrial Neoplasms Estradiol 3.0518566989 11473722 19148513
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.443581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4420426865
MESH:D004938 Esophageal Neoplasms Cisplatin 7.4415464296 16481741 16785472 15173087 17638652
MESH:D005234 Fatty Liver Cyclosporine 8.1019224547
MESH:D005234 Fatty Liver Dietary Fats 8.1018296743 17967931 19004024 19551842
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005355 Fibrosis Cyclosporine 9.1612168785 12639820
MESH:D005355 Fibrosis Dietary Fats 9.1618296743
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.7915102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.3919898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5115464296
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D006689 Hodgkin Disease Cisplatin 3.6916200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D007249 Inflammation Dietary Fats 2.4820412841
MESH:D007333 Insulin Resistance Dietary Fats 7.6011836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.6016627594 16393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.199022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.3115464296
MESH:D007674 Kidney Diseases Cisplatin 10.4712649298 18289764 12231392 15190930 19839026
MESH:D007674 Kidney Diseases Cyclosporine 10.4718776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 10.4715618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.916582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D007680 Kidney Neoplasms Estradiol 12.9115610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.9711231351
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.40598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.4018544905
MESH:D008171 Lung Diseases Asbestos, Serpentine 4.4217200189
MESH:D008175 Lung Neoplasms Asbestos, Serpentine 3.1711198217
MESH:D008175 Lung Neoplasms Cisplatin 3.1711798837 17225452 6189445
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6216891317 17203775 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008545 Melanoma Cisplatin 2.4912883367 16809738 12374674 15577323 11135225 18505091 17023156 12393984 18332650 16432458 18176117 16248763 17761969
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.9315990972
MESH:D008654 Mesothelioma Cisplatin 3.2817638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 6.0417671175
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3616810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.513581430
MESH:D009369 Neoplasms Cisplatin 2.9916773208
MESH:D009374 Neoplasms, Experimental Asbestos, Serpentine 4.9811704859
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.6715464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.7811399458 16427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D009447 Neuroblastoma Cisplatin 3.508761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.858761367
MESH:D009765 Obesity Dietary Fats 2.3121332399 20518802 19632207 11836018 18674790 16723640 17217161 18457598 20132043
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.524026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010051 Ovarian Neoplasms Cisplatin 5.1017225452 6897625 15464296 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 5.1019401270
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0319003803
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4315464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D010995 Pleural Diseases Asbestos, Serpentine 5.8310923243
MESH:D010997 Pleural Neoplasms Cisplatin 5.5217638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms bicalutamide 3.5618487222 17914592 19011039 19240160 15638997
MESH:D011471 Prostatic Neoplasms Estradiol 3.5616740699
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Serpentine 3.8615511213 18569384
MESH:D051437 Renal Insufficiency Cisplatin 4.5515464296
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.5514601052
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.748532709
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.5215464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.3318396642 17522103 15958060
MESH:D013736 Testicular Neoplasms Cisplatin 4.7515464296 17225452
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.971399818 6582329 7505956 6587162 3712494
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.388074119
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.3812973940 15464296 17225452
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.3116803524
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7515577323
MESH:D014839 Vomiting Cisplatin 4.8911897121
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:04141 Protein processing in endoplasmic reticulum
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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